Technology transfer

Application outputs, biotechnology spin-off companies
Besides basic research, great attention at the Institute is also paid to applied research and to the possibilities of practical application of research results. At present, the applied research at the Institute is supported (mainly in collaboration and with financial participation of implementation companies) by 6 grants (3x Research Centers 1M, 3x Heureka, 1x grant of the Ministry of Industry and Trade). Based on the results obtained at the Institute, several biotechnology spin-off companies have been established, some of which prosper well and are growing:
Top-Bio Ltd.	http://www.top-bio.cz/	Focused on the development and production of reagents for DNA fragment amplification using polymerase chain reaction. In 2004, turnover CZK 4 million.
EXBIO Praha Inc.	http://www.exbio.cz/	Focused on the research, development and production of monoclonal antibodies and recombinant proteins. In 2004, turnover CZK 23 million, 20 employees.
Apronex Ltd.	http://www.apronex.com/	Focused on the development and production of recombinant proteins. In 2004, turnover CZK 0.5 million, 1 employee.
Bioskin Ltd.		Focused on the development of recombinant skin for wound healing; still starting activity.
Cellvia Ltd.	http://www.cellvia.com/	Focused on the development of small molecule-based drugs; still starting activity.
AppGenics Ltd.	http://www.appgenics.com/	Focused on the preparation of labelled cRNA and cDNA probes for in situ hybridization, development of new vectors with required properties, preparation of recombinant proteins, gene cloning and arrangement and advanced technology for preparation of transgenic and gene-defective animal models. The company is also familiar with embryonic stem cell technology. In 2004, 3 employees.
rEcoli Ltd.		Focused on recombinant protein production. In 2004, it had 2 employees and turnover CZK 1 million (marketing and sale is ensured by the EXBIO Praha company).

Particular results that have already been implemented at the commercial basis include mainly:

Monoclonal antibodies for sperm protein detection,
which are used in the centres of assisted reproduction; production and marketing in spin-off company EXBIO Praha Inc. Dept. of Assoc. Prof. Pěknicová – for details see http://www.img.cas.cz/dbbf.

Monoclonal antibodies for detection of cytoskeletal proteins
and some other diagnostically interesting molecules obtained in part during work on the EUREKA projects. Implementation in the EXBIO Praha Inc. company
Dept. of Dr. Pavel Dráber – for details see http://www.img.cas.cz/dbc/.

Wound and burn healing using recombinant skin;
it is used during treatment of patients at the Clinic of Burns in Prague
Department of Dr. Matoušková – for details see http://www.img.cas.cz/Cell_Biology/.

Monoclonal antibodies against anti-tumour cytokine TRAIL receptors,
production and marketing in the spin-off company EXBIO Praha Inc.
Dept. of Dr. Anděra – for details see http://www.img.cas.cz/csa/.

Recombinant anti-tumour cytokine TRAIL and its highly effective derivates,
production in spin-off company Apronex Ltd.
Dept. of Dr. Anděra, for details see http://www.img.cas.cz/csa/,
htttp://www.apronex.com .

Monoclonal antibodies for detection of the HLA-G protein,
crucial for successful fertilization. The diagnostic kit (first of its kind worldwide) is produced in the EXBIO Praha Inc. company
Dept. of Prof. Hořejší – for details see:
http://www.img.cas.cz/mi/.

Monoclonal antibodies for detection of 14 signalling and 78 surface molecules of human leukocytes and other cells.
Implementation in the EXBIO Praha Inc. company, which sells these products to a number of international distribution companies, e.g. Serotec, Caltag, Pharmingen, Dynal, Sanbio, Alexis, Abcam. In its time, this large series of monoclonal antibodies had become the basis for the existence of spin-off company EXBIO Praha Inc. and to date represents the main part of its range of products and turnover
Dept. of Prof. Hořejší – for details see http://www.img.cas.cz/mi/,
http://www.img.cas.cz/mi/Horejsi-Table.html.

Recombinant antigens of EBV and CMV viruses,
which are used for production of diagnostic kits for detection of these viruses in the VIDIA Ltd. company; total sale turnover based on these products is CZK 0.5 million per year
Dept. of Dr. Sedláček – for details see http://www.img.cas.cz/igm/,
http://www.vidia.cz.

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