Research topics

Mast cells activation, transmembrane signaling, functional networks and topography of plasma membrane components, plasma membrane microdomains, endocytosis and exocytosis.

Current grant support

Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular and Cellular Immunology, grant No.: 1M0506)
Grant Agency of the Czech Republic (grant No.: GA301/09/1826)
Academy of Sciences of the Czech Republic [grant No.: IQS500520551 and 230634497f - (Program Nanotechnology for society)]

Most important recent papers

(2002-present; names of the lab members underlined)

Brdička, T., Imrich, M., Angelisová, P., Brdičková, N., Horváth, O., Špička, J., Hilgert, I., Lusková, P., Dráber, P., Novák, P., Engels, N., Wienands, J., Simeoni, L., Osterreicher, J., Aguado, E., Malissen, M., Schraven, B., Hořejší, V.: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 196: 1617-26, 2002. (PubMed) (FullText)

Hálová, I., Dráberová, L., Dráber, P.: A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fcε receptor. Int. Immunol. 14: 213-23, 2002. (PubMed) (FullText)

Dráberová, L., Dudková, L., Boubelík, M., Tolarová, H., Šmíd, F., Dráber, P.: Exogenous administration of gangliosides inhibits FcεRI-mediated mast cell degranulation by decreasing the activity of phospholipase Cγ. J. Immunol. 171: 3585-93, 2003. (PubMed) (FullText)

Tkaczyk, C., Horejsi, V., Shoko, I., Draber, P., Samelson, L.E., Satterthwaite, A.B., Nahm, D.H., Metcalfe, D.D., Gilfillan, A.M.: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following kit activation and FcρRI aggregation. Blood 104: 207-14, 2004. (PubMed) (FullText)

Volná, P., Lebduška, P., Dráberová, L., Šímová, Š., Heneberg, P., Boubelík, M., Bugajev, V., Malissen, B., Wilson, B.S., Hořejší, V., Malissen, M., Dráber, P.: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J. Exp. Med. 200: 1001-13, 2004. (PubMed) (FullText)

Tolar, P., Dráberová, L., Tolarová, H., Dráber, P.: Positive and negative regulation of Fcε receptor I-mediated signaling events by Lyn kinase C-terminal tyrosine phosphorylation. Eur. J. Immunol. 34: 1136-45, 2004. (PubMed) (FullText)

Tolarová, H., Dráberová, L., Heneberg, P., Dráber, P.: Involvement of filamentous actin in setting the threshold for degranulation in mast cells. Eur. J. Immunol. 34: 1627-36, 2004. (PubMed) (FullText)

Dráberová, L., Lebduška, P., Hálová, I., Tolar, P., Štokrová, J., Tolarová, H., Korb, J., Dráber, P.: Signaling assemblies formed in mast cells activated via Fcε receptor I dimers. Eur. J. Immunol. 34: 2209-19, 2004. (PubMed) (FullText)

Sulimenko,V., Dráberová, L., Sulimenko, T., Macurek, L., Richterová, V., Dráber, P., Dráber, Pa. Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases. J. Immunol. 176: 7243-7253, 2006. (PubMed) (FullText)

Heneberg, P., Lebduška, P., Dráberová, L., Korb, J., Dráber, P.: Topography of plasma membrane microdomains and its consequences for mast cell signaling. Eur. J. Immunol. 36: 2795-2806, 2006. (PubMed) (FullText)

Smrž, D., Dráberová, L., Dráber, P.: Non-apoptotic phosphatidylserine externalization induced by engagement of glycosylphosphatidylinositol-anchored proteins. J. Biol. Chem. 282: 10487-10497, 2007. (PubMed) (FullText)

Dráberová, L., Shaik, G. M., Volná, P., Heneberg, P., Tůmová, M., Lebduška, P., Korb, J. and Dráber, P. Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker. J. Immunol., 179, 5169-5180, 2007 (PubMed) (FullText)

Dráber, P., Dráberová, L., Heneberg, P., Šmíd, F., Farghali, H.eand Dráber, P. Preformed STAT3 transducer complexes in human HepG2 cells and rat hepatocytes. Cell Signal., 19, 2400-2412, 2007 (PubMed) (FullText)

Lebduška, P., Korb, J., Tůmová, M., Heneberg, P. and Dráber, P. Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells. J. Immunol. Methods. 2007 (PubMed) (FullText)

Jirkovská, M., Majer, F., Šmídová, J., Stříteský, J., Shaik, G. M., Dráber, P. , Vítek, L., Mareček, Z. and Šmíd, F. Changes in GM1 ganglioside content and localization in cholestatic rat liver. Glycoconj. J., 24, 231-241, 2007 (PubMed) (FullText)

Shaik, G. M., Dráberová, L., Dráber, P., Boubelík, M. and Dráber, P. Tetraalkylammonium derivatives as real-time PCR enhancers and stabilizers of the qPCR mixtures containing SYBR Green I. Nucleic Acids Res. 36, e93-103, 2008 (PubMed) (FullText)

Smrž, D., Lebduška, P., Dráberová, L., Korb, J. and Dráber, P. Engagement of phospholipid scramblase 1 in activated cells; Implication for phosphatidylserine externalization and exocytosis. J. Biol. Chem. 283, 10904-10918, 2008 (PubMed) (FullText)

Reviews

Heneberg, P., Dráber, P.: Nonreceptor protein tyrosine and lipid phosphatases in type I Fcε receptor-mediated activation of mast cells and basophils. Int. Arch. Allergy Immunol. 128: 253-63, 2002. (PubMed) (FullText)

Heneberg, P., Dráber, P.: Regulation of cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils. Curr. Med. Chem. 12: 1859-71, 2005. (PubMed) (FullText)

Lusková, P., Dráber, P.: Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr. Pharm. Des. 10: 1727-37, 2004. (PubMed) (FullText)

Dráber, P., Dráberová, L.: Lifting the fog in store-operated Ca²⁺ entry. Trends Immunol. 26: 621-624, 2005. (PubMed) (FullText)

Other results

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