Research topics
Analysis of TRAIL receptors and Death receptor 6 (DR6) signaling and elucidation of their roles in proliferation and apoptosis of transformed and hematopoietic cells; characterization of the adaptor protein Daxx functions in the regulation of apoptosis and transcription.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular and Cellular Immunology, 1M0506)
EC FP6 STREP project (Oncodeath, LSHG-CT-2006-037278)
GA AS CR (Nanomed - KAN200520703, KJB500520801)
Most important recent papers
(2002-present; names of the lab members underlined)Čermák, L., Šímová, S., Pintzas, A., Hořejší, V., Anděra, L.: Apoptosis of TF-1 cells induced by engagement of CD43: roles of transcription, expression of Daxx and adhesion molecules. J. Biol. Chem. 277: 7955-7961, 2002. (PubMed)
Weber, T., Lu, M., Anděra, L., Lahm, H., Gellert, N., Fariss, M.W., Kořínek, V., Sattler, W., Ucker, D.S., Terman, A., Schroder, A., Erl, W., Brunk, U.T., Coffey, R.J., Weber, C., Neužil, J.: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin. Cancer Res. 8: 863-869, 2002. (PubMed)
Plášilová, M., Živný, J., Jelínek, J., Neuwirtová, R., Čermák, J., Nečas, E., Anděra, L., Stopka, T.: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia 16: 67-73, 2002. (PubMed)
Tomasetti, M, Rippo, M.R., Alleva, R., Moretti, S., Andera, L., Neuzil, J., Procopio, A.: α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells. Br. J. Cancer 90: 1644-1653, 2004. (PubMed)
Dubska, L., Andera, L., Sheard, M.A.: HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis. FEBS Lett. 579: 4149-58, 2005. (PubMed)
Drosopoulos, K.G., Roberts, M.L., Cermak, L., Sasazuki, T., Shirasawa, S., Andera, L., Pintzas, A.: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J. Biol. Chem. 280: 22856-67, 2005. (PubMed)
Tomasetti M, Andera L, Alleva R, Borghi B, Neuzil J, Procopio A. Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis. FEBS Lett. 580: 1925-31, 2006. (PubMed)
Oikonomou, E., Kothonidis, K., Taoufik, E., Probert, E., Zografos, G., Nasioulas, G., Andera, L., and Pintzas, A. Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. Br J Cancer 97: 73-84, 2007. (PubMed)
Simova, S., Klima, M., Cermak, L., Sourkova, V., and Andera, L. Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis 13: 423-436, 2008. (PubMed)
Doubravska, L., Simova, S., Cermak, L., Valenta, T., Korinek, V., and Andera, L. Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells. Apoptosis 13: 573-587, 2008. (PubMed)
Khunkaewla, P., Schiller, H. B., Paster, W., Leksa, V., Cermak, L., Andera, L., Horejsi, V., and Stockinger, H. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Mol Immunol 45: 1703-1711, 2008. (PubMed)
Reviews
Neužil, J., Kagedal, K., Anděra, L., Weber, C., Brunk, U.T.: Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic activity. Apoptosis 7: 179-87, 2002. (PubMed)
Neuzil, J., Stantic, M., Zobalova, R., Chladova, J., Wang, X., Prochazka, L., Dong, L., Andera, L., Ralph, SJ.: Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name? Biochem Biophys Res Commun. 355(4):855-9, 2007 (PubMed)
Teaching, lectures, public presentations
MB150P79 - Molecular Mechanisms of Apoptosis - Faculty of Science, Charles University, Prague; presentations for Czech students.