Research topics
Mapping and functional analysis of genes that control resistance to infection, genetic control of atopy, activation of lymphocytes and cancer susceptibility
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular Ecology of Vectors and Pathogens, grant No.: LC06009)
Grant Agency of the Czech Republic (grant No.: GA310/08/1697)
Most important recent papers
(2002-present; names of the lab members underlined)Badalová, J., Svobodová, M., Havelková, H., Vladimirov,V., Vojtíšková, J., Engová, J., Pilčík, T., Volf, P., Demant, P., Lipoldová, M.: Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Genes Immun. 3: 187-195, 2002. (PubMed)
Lipoldová, M., Svobodová, M., Havelková, H., Krulová, M., Badalová, J., Nohýnková, E., Hart, A.A.M., Schlegel, D., Volf, P., Demant, P.: Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis. Immunogenetics 54: 174-183, 2002. (PubMed)
Vladimirov, V., Badalová, J., Svobodová, M., Havelková, H., Hart, A.A.M., Blažková, H., Demant, P., Lipoldová, M.: Different genetic control of cutaneous and visceral disease after Leishmania major infection in mouse. Infect. Immun. 71: 2041-2046, 2003. (PubMed)
Czarnomska, A., Krysiak, E., Piskorowska, J., Sitarz, M., Pysniak, K., Pilčík, T., Demant, P.: Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland. Cancer Res. 63: 4533-4537, 2003. (PubMed)
Lipoldová, M., Havelková, H., Badalová, J., Demant, P.: Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function, and lung tumor susceptibility. Int. J. Cancer 114: 394-399, 2005. (PubMed)
Gusareva, E.S., Bragina, E.J., Deeva, E.V., Kazakevich, N.V., Puzyrev, V.P., Ogorodova, L.M., Lipoldová, M.: Cat is a major allergen in patients with asthma from west Siberia, Russia. Allergy 61: 509-10, 2006. (PubMed)
Havelková,H., Badalová, J., Svobodová, M., Vojtíšková, J., Kurey, I., Vladimirov, V., Demant, P., Lipoldová, M.: Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 7: 220-233, 2006. (PubMed)
Gusareva, E.S., Ogorodova L.M., Chernyak B.A., Lipoldova, M. Relationship between total and specific IgE in patients with asthma from Siberia. Journal of Allergy and Clinical Immunology 121:781, 2008. (PubMed)
Gusareva, E.S., Havelkova, H., Blazkova, H., Kosarova, M., Kucera, P., Kral, V., Salyakina, D., Müller-Myhsok, B., Lipoldova, M. Mouse to human comparative genetics reveals a novel immunoglobulin E - controlling locus on Hsa8q12. Immunogenetics 61: 15-25, 2009. (PubMed)
Reviews
Lipoldová, M., Demant, P.: Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat. Rev. Genet. 7: 294-305, 2006. (PubMed)
Teaching, lectures, public presentations
Immunity to Infection courses for Czech and English speaking students, Third Faculty of Medicine, Charles University, Prague (presentations)
Český rozhlas Leonardo (interview on Czech Radio)