Projects
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Synthetic fluorine chemistryNew synthetic methodologies for the introduction of fluoro-, fluoromethyl-, difluoromethyl-, trifluoromethyl- and other groups are being developed. Fluorinated group transfer, rearrangements, SNAr on fluorinated substrates and the preparation and reactivity of fluorinated phosphorus and sulfur compounds is explored. |
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Biocatalysis in unnatural mediaIn this project we exploit extremely inert and hydrophobic properties of perfluorinated hydrocarbons by employing them as a reaction media in enzyme catalyzed processes. We use lipases and other kinds of enzymes in preparative organic synthesis. The aim is the preparation of enantiomerically pure high value products by enzymatic method. Fluorous biphase separation methodology and fluorophobic interactions are also investigated. |
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Synthesis of fluorinated derivatives of natural products and fluorine containing bioactive compoundsMany marketed drugs and agrochemicals contain one or more fluorine atoms in the molecule. This often brings improvements including better bioavailability and increased potency and lowered metabolic rate. We are working on the synthesis of new fluorinated derivatives of naturally occurring compounds with improved biological activity. |