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Centre for New Antivirals and Antineoplastics
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 Centre for New Antivirals and Antineoplastics
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143. Bobula, T.; Hocek, M.; Kotora, M.: "Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides" Tetrahedron 2010, 66, 530-536.
142. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
141. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
140. Šála, M.; Hřebabecký, H; Dračínský, M; Masojídková, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Norbornane as the novel pseudoglycone moiety in nucleosides" Tetrahedron 2009, 65, 9291-9299.
139. Hřebabecký, H.; Dračínský, M.; Holý, A.: "New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2-dimethanol template" Collect. Czech. Chem. Commun. 2009, 74, 1425-1441.
138. Doláková, P.; Dračínský, M.; Masojídková, M.; Šolínová, V.; Kašička, V.; Holý, A.: "Acyclic Nucleoside Bisphosphonates: Synthesis and Properties of Chiral 2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines" Eur. J. Med. Chem. 2009, 44, 2408-2424.
137. Doláková, P.; Dračínský, M.; Fanfrlík, J.; Holý, A.: "Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing Phosphonomethylphosphinyl Moiety and Studies of Their Phosphorylation Reaction" Eur. J. Org. Chem. 2009, 7, 1082-1092.
136. Hocková, D.; Holý, A.; Masojídková, M.; Keough, D. T.; de Jersey, J.; Guddat, L. W.: "Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit /Plasmodium falciparum/ hypoxanthine-guanine-xanthine phosphoribosyltransferase" Bioorg. Med. Chem. 2009, 17, 6218-6232.
135. Keough, D. T.; Hocková, D.; Holý, A.; Naesens, L.; Skinner- Adamsm, T.; de Jersey, J.; Guddat, L. W.: "Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics" J. Med. Chem. 2009, 52, 4391-4399.
134. Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.: "Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase" Tetrahedron 2009, 65, 8486-8492.
133. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of (Purin-6-yl)acetates and Their Transformations to 6-(2-Hydroxyethyl)- and 6-(Carbamoylmethyl)purines" Collect. Czech. Chem. Commun 2009, 74, 1035-3059.
132. Otová, B.; Hrdý, J.; Votruba, I.; Holý, A.: "In Vivo Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG" Anticancer Res. 2009, 29, 1295-1302.
131. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
130. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
129. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel Racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
128. Mlčochová, P.; Bařinka, C.; Tykvart, J.; Šácha, P.; Konvalinka, J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM'" Prostate 2009, 69, 471-479.
127. Zábranský, A.; Hadravová, R.; Štokrová, J.; Sakalian, M.; Pichová, I.: "Premature processing of mouse mammary tumor virus Gag polyprotein impairs intracellular capsid assembly" Virology 2009, 384, 33-37.
126. Kohoutová, Z.; Rumlová, M.; Andreánsky, M.; Sakalian, M.; Hunter, E.; Pichová, I.; Ruml, T.: "The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus" Virology 2009, 384, 59-68.
125. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoro­borates; The Scope and Limitations in the Synthesis of Modified Purines" Synthesis 2009, 1309-1317.
124. Novotný, M.; Hrabálek, A.; Janůšková, B.; Novotný, J.; Vávrová, K.: "Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers" Bioorg. Med. Chem. Lett. 2009, 19, 344-347.
123. Novotný, J.; Janůšková, B.; Novotný, M.; Hrabálek, A.; Vávrová, K.: "Short-Chain Ceramides Decrease Skin Barrier Properties" Skin. Pharmacol. Physiol. 2009, 22, 22-30.
122. Hoffman, H. E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2009, 63, 62-67.
121. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "The strand transfer oligonucleotide inhibitors of HIV-integrase" J. Enzym. Inhib. Med. Chem. 2008, 24, 241-246.
120. Klimentová, J.; Kosák, P.; Vávrová, K.; Holas, T.; Novotný, J.; Hrabálek, A.: "Transkarbams with Terminal Branching as Transdermal Permeation Enhancers" Bioorg. Med. Chem. Lett. 2008, 18, 1712-1715.
119. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers" Eur. J. Pharm. Biopharm. 2008, 70, 597-604.
118. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species" Eur. J. Pharm. Biopharm. 2008, 70, 901-907.
117. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and Homocyclotrimerization Reactions of Protected 1-Alkynyl-2-deoxyribofuranose. Synthesis of C-Nucleosides, C-Di- and C-Trisaccharide Analogues" Tetrahedron 2008, 64, 5200-5207.
116. Janková, Š.; Dračínský, M.; Císařová, I.; Kotora, M.: "Synthesis and Rearrangement of Dewar Benzenes into Biaryls. Experimental Evidence for the Conrotatory Ring Opening" Eur. J. Org. Chem. 2008, 47-51.
115. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave Enhanced [2+2+2]-Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
114. Eignerová, B.; Dračínský, M.; Kotora, M.: "Perfluoroalkylation via Cross-metathesis of Alkenes with (Perfluoroalkyl)propenes" Eur. J. Org. Chem. 2008, 4493-4499.
113. Herrmann, P.; Buděšínský, M.; Kotora, M.: "Total Synthesis of (±)-Estrone and Zirconocene-Promoted Cyclization of 2-Fluoro-1,7-octadienes and Ru-Catalyzed Ring Closing metathesis" J. Org. Chem. 2008, 73, 6202-6206.
112. Novák, P.; Pour, M.; Špulák, M.; Votruba, I.; Kotora, M.: "Extention of the Library of Biological Active γ-Alkylidene Butenolides" Synthesis 2008, 3465-3472.
111. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol" Collect. Czech. Chem. Commun. 2008, 73, 44-58.
110. Bartoňová, V.; Král, V.; Sieglová, I.; Brynda, J.; Fábry, M.; Hořejší, M.; Kožíšek, M.; Grantz Šašková, K.; Konvalinka, J.; Sedláček, J.; Řezáčová, P.: "Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies" Antiviral Res. 2008, 78, 275-277.
109. Řezáčová, P.; Kožíšek, M.; Moy, S.F.; Sieglová, I.; Joachimiak, A.; Machius, M.; Otwinowski, Z.: "Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates" Mol Microbiol. 2008, 69, 895-910.
108. Kožíšek, M.; Svatoš, A.; Budešínský, M.; Muck, A.; Bauer, M.C.; Kotrba, P.; Ruml, T.; Havlas, Z.; Linse, S.; Rulíšek, L.: "Molecular design of specific metal-binding peptide sequences from protein fragments" Chemistry-Eur. J. 2008, 14, 7836-7846.
107. Cígler, P.; Král, V.; Kožíšek, M.; Konvalinka, J.; Mirsky, V.: "Anomalous adsorptive properties of HIV protease: Indication of two-dimensional crystallization?" Colloids and Surfaces B: Biointerfaces 2008, 64, 145-149.
106. Král, V.; Mader, P.; Collard, R.; Fábry, M.; Hořejší, M.; Řezáčová, P.; Kožíšek, M.; Závada, J.; Sedláček, J.; Rulíšek, M.; Brynda, J.: "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations" Proteins 2008, 71, 1275-1287.
105. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2008, 63, 62-67.
104. Grantz Šašková, K.; Kožíšek, M.; Lepšík, M.; Brynda, J.; Řezáčová, P.; Václavíková, J.; Kagan, R.; Machala, L.; Konvalinka, J.: "Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility to HIV Protease Inhibitor Lopinavir" Protein Sci. 2008, 17, 1555-1564.
103. Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáčová, P.; Brynda, J.; Pokorná, J.; Plešek, J.; Gruner, B.; Grantz Šašková, K.; Václavíková, J.; Král, V.; Konvalinka, J.: "Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming, Antiviral Resistance" J. Med. Chem. 2008, 51, 4839-4843.
102. Kožíšek, M.; Grantz Šašková, K.; Řezáčová, P.; Maarseveen, N.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.N.; Konvalinka, J.: "Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region" J. Virol. 2008, 82, 5869-5878.
101. Wildová, M.; Hadravová, R.; Štokrová, J.; Křížová, I.; Ruml, T.; Hunter, E.; Pichová, I.; Rumlová, M.: "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" Virology 2008, 380, 157-163.
100. Macek, P.; Žídek, L.; Rumlová, M.; Pichová, I.; Sklenář, V.: "1H, 13C, and 15N resonance assignment of the N-terminal domain of Mason-Pfizer monkey virus capsid protein, CA 1-140" Biomol NMR Assign 2008, 2, 43-45.
99. Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, H.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.: "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" J. Virol. 2008, 82, 12520-12534.
98. Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic polymerization of phosphonate nucleosides" ChemBioChem 2008, 9, 2883-2888.
97. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
96. Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.: "Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine" Biochem. Pharmacol. 2008, 76, 997-1005.
95. Votruba, I.; Otová, B.; Holý, A.: "Acyklické nukleosidfosfonáty jako potenciální antineoplastika" Čas. Lék. čes. 2008, 147, 471-477.
94. Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines" Tetrahedron 2008, 64, 10355-10364.
93. Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665-678.
92. Dračínský, M.; Krečmerová, M.; Holý, A.: "Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy" Bioorg. Med. Chem. 2008, 16, 6778-6782.
91. Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations" Org. Biomol. Chem. 2008, 6, 2377-2387.
90. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
89. Bambuch, V.; Pohl, R.; Hocek, M.: "Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides" Eur. J. Org. Chem. 2008, 2783-2788.
88. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues" Tetrahedron 2008, 64, 5200-5207.
87. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
86. Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlar, T.; Holý, A.: "Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates" Collect. Czech. Chem. Commun. 2008, 73, 275-291.
85. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide – Scope and Limitations of the Reaction" Synlett 2008, 543–546.
84. Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.: "Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells" Biochem. Pharmacol. 2008, 75, 965-972.
83. Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.: "Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2008, 18, 1364-1367.
82. Rovenská, M.; Hlouchová, K.; Šácha, P.; Mlčochová, P.; Horák, V.; Zámečník, J.; Bařinka, C.; Konvalinka, J.: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs" Prostate 2008, 68, 171-182.
81. Bařinka, C.; Hlouchová, K.; Rovenská, M.; Majer, P.; Dauter, M.; Hin, N.; Ko, Y.-S.; Tsukamoto, T.; Slusher, B.S., Konvalinka, J.; Lubkowski, J.: "Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs" J. Mol. Biol. 2008, 376, 1438-1450.
80. Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides" Bioorg. Med. Chem. 2008, 16, 1400–1424.
79. Pomeisl, K.; Votruba, I.; Holý, A.; Pohl, R.: "Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-lymphoma" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1025-1028.
78. Dejmek, M.; Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 2-(hydroxymethyl)bicyclo[2.2.1]heptane" Collect. Czech. Chem. Commun. 2007, 72, 1523-1544.
77. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleosides and Pro-Tides derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol" Collect. Czech. Chem. Commun. 2007, 72, 1331-1349.
76. Zápotocký, M.; Hanzalová, J.; Starková, J.; Votruba, I.; Holý, A.; Otová, B.: "Experimental Therapy with 9-[2-(Phosphonomethoxy)ethyl]- 2,6-diaminopurine (PMEDAP): Origin of Resistance" Folia Biologica (Praha) 2007, 53, 79-84.
75. Nencka, R.; Votruba, I.; Hřebabecký, H.; Jansa, P.; Tloušťová, E.; Horská, K.; Masojídková, H.; Holý, A.: "Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase" J. Med. Chem. 2007, 50, 6016-6023.
74. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines" Collect. Czech. Chem. Commun. 2007, 72, 965-983.
73. Potměšil, P; Holý, A.; Kmoníčková, E.; Křížková, J.; Zídek, Z.: "Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3" J. Biomed. Sci. 2007, 14, 59-66.
72. Duraffour, S.; Snoeck, R.; Krečmerová, M.; van Den Oord, K.; De Vos, R.; Holý, A.; Crance, J.-M.; Garin, D.; De Clercq. E.; Andrei, G.: "Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models" Antimicrob. Agents Chemother. 2007, 51, 4410-4419.
71. Krečmerová, M.; Holý, A.; Pohl, R.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" J. Med. Chem. 2007, 50, 5765-5772.
70. Kožíšek, M.; Bray, J.; Řezáčová, P.; Šašková, K.; Brynda, J.; Pokorná, J.; Mammano, F.; Rulíšek, L.; Konvalinka, J.: "Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants" J. Mol. Biol. 2007, 374, 1005-1016.
69. Bambuch, V.; Otmar, M.; Pohl, R.; Masojídková, M.; Holý, A.: "C-Functionalization of 9-deazapurines by cross-coupling reactions" Tetrahedron 2007, 63, 1589-1601.
68. Krečmerová, M.; Holý, A.; Pískala, A.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds" J. Med. Chem. 2007, 50, 1069-1077.
67. Renders, M.; Emmerechts, G.; Rozenski, J.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase" Angew. Chem. Int. Ed. 2007, 46, 2501-2504.
66. Lebeau, I.; Andrei, G.; Krečmerová, M.; De Clercq, E.; Holý, A.; Snoeck, R.: "Inhibitory activity of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate SV 40 strains" Antimicrob. Agents Chemother. 2007, 51, 2268-2273.
65. Krečmerová, M.; Holý, A.; Masojídková, M.: "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position" Collect. Czech. Chem. Commun. 2007, 72, 927-951.
64. Doláková, P.; Masojídková, M.; Holý, A.: "Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives" Heterocycles 2007, 71, 1107-1115.
63. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines" Tetrahedron: Asymmetry 2007, 18, 2233-2247.
62. Kmoníčková, E.; Melkusová, P.; Farghali, H.; Holý, A.; Zídek, Z.: "Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells" Nitric Oxide-Biol. Chem. 2007, 17, 160-169.
61. Zídek, Z.; Kmoníčková, E.; Holý, A.: "Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates" Eur. J. Pharmacol. 2007, 574, 77-84.
60. Vávrová, K.; Hrabálek, A.; Mac-Mary, S.; Humbert, P.; Muret, P.: "Ceramide analogue 14S24 selectively recovers perturbed human skin barrier" Brit. J. Dermatol. 2007, 157, 704-712.
59. Mlčochová, P.; Plechanovová, A.; Bařinka, C.; Mahadeva, D.; Saldanha, C.; Rulíšek, L.; Konvalinka, J.: "Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis" FEBS J 2007, 274, 4731-4741.
58. Bařinka, C.; Rovenská, M.; Mlčochová, P.; Hlouchová, K.; Plechanovová, A.; Majer, P.; Tsukamoto, T.; Slusher, B. S.; Konvalinka, J.; Lubkowski, J.: "Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II" J. Med. Chem. 2007, 50, 3267-3273.
57. Hasník, Z.; Šilhár, P.; Hocek, M.: "Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent" Tetrahedron Lett. 2007, 48, 5589-5592.
56. Vávrová, K.; Lorencová, K.; Klimentová, J.; Novotný, J.; Hrabálek, A.: "HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA)" J Chromatogr. B 2007, 853, 198-203.
55. Nobilis, M.; Pour, M.; Šenel, P.; Pavlík, J.; Kuneš, J; Vopršalová, M.; Kolářová, L.; Holčapek, M.: "Metabolic profiling of a potential antifungal drug, 3-(4-bromophenyl)-5-acetoxymethyl-2,5-dihydrofuran-2-one, in mouse urine using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection" J. Chromatogr. B 2007, 853, 10-19.
54. Kubát, P.; Lang, K.; Cígler, P.; Kožíšek, M.; Matějíček, M; Janda, P.; Zelinger, Z.; Procházka, K.; Král, V.: "Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease" J. Phys. Chem. B 2007, 111, 4539-4546.
53. Pomeisl, K.; Holý, A.; Pohl, R.: "Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potencial multisubstrate inhibitors of thymidine phosphorylase" Tetrahedron Lett. 2007, 48, 3065-3067.
52. Hlouchová, K.; Bařinka, C.; Klusák, V.; Šácha, P.; Mlčochová, P.; Majer, P.; Rulíšek, L.; Konvalinka, J.: "Biochemical characterization of human glutamate carboxypeptidase III" J. Neurochem. 2007, 101, 682-696.
51. Németh-Pongrácz, V.; Barabás, O.; Fuxreiter, M.; Simon, I.; Pichová, I.; Rumlová, M.; Zábranská, H.; Svergun, D.; Petoukhov, M; Harmat, V.; Klement, É; Hunyadi-Gulyás, É; Medzihradszky, K. F.; Kónya, E.; Vértessy, B. G.: "Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins" Nucl. Acids Res. 2007, 35, 495-505.
50. Zábranská, H.; Tůma, R.; Kluh, I.; Svatoš, A.; Ruml, T.; Hrabal, R.; Pichová, I.: "The Role of the S-S Bridge in Retroviral Protease Function and Virion Maturation" J. Mol. Biol. 2007, 365, 1493-1504.
49. Bařinka, C.; Starková, J.; Konvalinka, J.; Lubkowski, J.: "A high-resolution structure of ligand-free human glutamate carboxypeptidase II" Acta Cryst. 2007, F63, 150-153.
48. Šácha, P.; Zámečník, J.; Bařinka, C.; Hlouchová, K.; Vícha, A.; Mlčochová, P.; Hilgert, I.; Eckschlager, T.; Konvalinka, J.: "Expression of glutamate carboxypeptidase II in human brain" Neuroscience 2007, 144, 1361-1372.
47. Nijhuis, M.; van Maarseveen, N. M.; Lastere, S.; Schipper, P.; Coakley, E.; Glass, B.; Rovenska, M.; de Jong, D.; Chappey, C.; Goedegebuure, I. W.; Heilek-Snyder, G.; Dulude, D.; Cammack, N.; Brakier-Gingras, L.; Konvalinka, J.; Parkin, N.; Kräusslich, H. G.; Brun-Vezinet, F.; Boucher, C. A. B.: "A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism" PLoS Med 2007, 4, e36.
46. Németh-Pongrácz, V.; Snášel, J.; Rumlová, M.; Pichová, I.; Vértessy, B. G.: "Interacting partners of M-PMV nucleocapsid-dUTPase" Nucleos. Nucleot. Nucl. 2006, 25, 1197-1200.
45. Sobociková, M.; Štěpnička, P.; Ramella, D.; Kotora, M.: "Synthesis of 1-alkanoyl-1'-(trifluoroacetyl)ferrocenes" Collect. Czech. Chem. Commun. 2006, 71, 190-196.
44. Nečas, D.; Turský, M.; Tišlerová, I.; Kotora, M.: "Nickel-catalyzed cyclization of α,ω-dienes: formation vs. cleavage of C–C bonds" New J. Chem. 2006, 30, 671-674.
43. Turský, M.; Nečas, D.; Drabina, P.; Sedlák, M.; Kotora, M.: "Rhodium-Catalyzed Deallylation of Allylmalonates and Related Compounds" Organometallics 2006, 25, 901-907.
42. Herrmann, P.; Kotora, M.; Buděšínský, M.; Šaman, D.; Císařová, I.: "Synthesis of (±)-3-Methoxyestra-1,3,5(10)-trienes by the Repetitive Use of Negishi Reagent" Org. Lett. 2006, 8, 1315-1318.
41. Holý, A.: "Antiviral acyclic nucleoside phosphonates structure activity studies" Antivirals Res. 2006, 71, 248-253.
40. Česnek, M.; Masojídková, M.; Holý, A.; Šolínová, V.; Koval, D; Kašička, V.: "Synthesis and properties of 2-guanidinopurines" Collect. Czech. Chem. Commun. 2006, 71, 1303-1319.
39. Potměšil, P.; Krečmerová, M.; Kmoníčková, E.; Holý, A.; Zídek, Z.: "Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives" Eur. J. Pharmacol. 2006, 540, 191-199.
38. Hořejší, K.; Andrei, G.; De Clerq, E.; Snoeck, R.; Pohl, R; Holý, A.: "Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity" Bioorg. Med. Chem. 2006, 14, 8057-8065.
37. Šolínová, V.; Kašička, V.; Koval, D.; Česnek, M.; Holý, A.: "Determination of acid–base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis" Electrophoresis 2006, 27, 1006-1019.
36. Hocek, M.; Šilhár, P.; Pohl, R.: "Cytostatic and activiral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3'-deoxyribonucletides" Collect. Czech. Chem. Commun. 2006, 71, 1484-1496.
35. Turek, P.; Novák, P.; Pohl, R.; Hocek, M.; Kotora, M.: "Preparation of Highly Substituted 6-Arylpurine Ribonucleosides by Ni-Catalyzed Cyclotrimerization. Scope of the Reaction" J. Org. Chem. 2006, 71, 8978-8981.
34. Klimentová, J.; Kosák, P.; Vávrová, K.; Holas, T.; Hrabálek, A.: "Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids" Bioorg. Med. Chem. 2006, 14(23), 7681-7687.
33. Holas, T.; Vávrová, K.; Šíma, M.; Klimentová, J.; Hrabálek, A.: "Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12" Bioorg. Med. Chem. 2006, 14(23), 7671-7680.
32. Kuchař, M.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of Purines Bearing Functionalized C-Substituents by the Conjugate Addition of Nucleophiles to 6-Vinylpurines and 6-Ethynylpurines" Eur. J. Org. Chem. 2006, 5083-5098.
31. Liebl, D.; Difato, F.; Horníková, L.; Mannová, P.; Štokrová, J.; Forstová, J: "Mouse Polyomavirus Enters Early Endosomes, Requires Their Acidic pH for Productive Infection, and Meets Transferrin Cargo in Rab11-Positive Endosomes" J. Virol. 2006, 80, 4610-4622.
30. Hřebabecký, H.; Masojídková, M.; Dračínský, M.; Holý, A.: "Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol" Collect. Czech. Chem. Commun. 2006, 71, 871-888.
29. Šála, M.; Hřebabecký, H.; Masojídková, M.; Holý, A.: "Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo{2.2.1]hept-5-ene-2,2-dimethanols" Collect. Czech. Chem. Commun. 2006, 71, 635-649.
28. Hocek, M.; Šilhár, P.; Shih, I.; Mabery, E.; Mackman, R.: "Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine L-ribonucleosides" Bioorg. Med. Chem. Lett. 2006, 16, 5290-5293.
27. Hrabálek, A.; Doležal, P.; Vávrová, K.; Zbytovská, J.; Holas, T.; Klimentová, J.; Novotný, J.: "Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin" Pharm. Res. 2006, 5, 912-919.
26. Čapek, P.; Pohl, R.; Hocek, M.: "Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines." Org. Biomol. Chem. 2006, 4, 2278-2284.
25. Šilhár, P.; Pohl, R.; Votruba, I.; Klepetářová, B.; Hocek, M.: "Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl- 2-(Hydroxymethyl)purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2006, 71, 788-803.
24. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis and Cytostatic Activity of Novel 6-(Difluoromethyl)purine Bases and Nucleosides" Synthesis 2006, 1848-1852.
23. Krečmerová, M.; Masojídková, M.; Holý, A.: "Preparation of C-5 Substituted Cidofovir Derivatives" Collect. Czech. Chem. Commun. 2006, 71, 579-594.
22. Vrbovská, S.; Holý, A.; Pohl, R.; Masojídková, M.: "Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines" Collect. Czech. Chem. Commun. 2006, 71, 543-566.
21. Novák, P.; Pohl, R.; Kotora, M.; Hocek, M.: "Synthesis of C-Aryldeoxyribosides by [2 + 2 + 2]-Cyclotrimerization Catalyzed by Rh, Ni, Co, and Ru Complexes" Org. Lett. 2006, 8, 2051-2054.
20. Majerová-Uhlíková, T.; Dantuma, N. P.; Lindsten, K.; Masucci, M. G.; Konvalinka, J.: "Non-infectious Fluorimetric Assay for Phenotyping of Drug-Resistant HIV Proteinase Mutants" J. Clin. Virol. 2006, 36, 50-59.
19. Vale-Silva, L. A.; Buchta, V.; Vokurková, D.; Pour, M.: "Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow citometry" Bioorg. Med. Chem. Lett. 2006, 16, 2492-2495.
18. Matějíček, P., Cígler, P., Procházka, K., and Král, V.: "Molecular Assembly of Metallacarboranes in Water: Light Scattering and Microscopy Study" Langmuir 2006, 22, 575-581.
17. Mesters, J. R.; Bařinka, C.; Li, W., Tsukamoto, T.; Majer, P.; Slusher, B.; Konvalinka, J.; Hilgenfeld, R.: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer" EMBO J. 2006, 25, 1375-1384.
16. Hořejší, K.; Pohl, R.; Holý, A.: "Tricyclic purine analogs derived from 2-amino-6-chloropurine and 2,6-diaminopurine and their methylated quarternary salts" Collect. Czech. Chem. Commun. 2006, 71, 77-90.
15. Bouřa, E.; Liebl, D.; Špíšek, R.; Frič, J.; Marek, M.; Štokrová, J.; Holáň, V.; Forstová, J.: "Polyomavirus EGFP-pseudocapsids: Analysis of model particles for introduction of proteins and peptides into mammalian cells" FEBS Letters 2005, 579, 6549–6558.
14. Chalupová, Š.; Holý, A.; Masojídková, M.: "Synthesis of some N4-substituted derivatives of 1-[2-(phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N4-substituted derivatives of Cidofovir" Collect. Czech. Chem. Commun. 2005, 70, 2066-2074.
13. Chalupová, Š.; Holý, A.; Masojídková, M.: "Synthesis of some N4-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir)" Collect. Czech. Chem. Commun. 2005, 70, 2053-2065.
12. Bauerová-Zábranská, H.; Stokrová, J.; Stříšovský, K.; Hunter, E.; Ruml, T.; Pichová, I.: "The RNA Binding G-patch Domain in Retroviral Protease Is Important for Infectivity and D-type Morphogenesis of Mason-Pfizer Monkey Virus" J. Biol. Chem. 2005, 280, 42106-42112.
11. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of 2-Substituted 6-(Hydroxymethyl)Purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2005, 70, 1669-1695.
10. Čapek, P.; Hocek, M.: "Efficient One-Step Synthesis of Optically Pure (Adenin-8-yl)phenylalanine Nucleosides" Synlett 2005, 3005-3007.
9. Cígler, P.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Otwinowski, Z.; Pokorná, J.; Plešek, J.; Grüner, B.; Dolečková-Marešová, L.; Máša, M.; Sedláček, J.; Bodem, J.; Kräusslich, H.-G.; Král, V.; Konvalinka, J.: "From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease" Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 15394-15399.
8. Horáková, D.; Rumlová, M.; Pichová, I.; Ruml, T.: "Luminometric method for screening retroviral protease inhibitors" Anal. Biochem. 2005, 345, 96-101.
7. Vávrová, K.; Zbytovská, J.; Hrabálek, A.: "Amphiphilic transdermal permeation enhancers: Structure-activity relationships" Curr. Med. Chem. 2005, 12, 2273-2291.
6. Fáková, H.; Pour, M.; Kuneš, J.; Šenel, P.: "Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine and its analogues" Tetrahedron Lett. 2005, 46, 8137-8140.
5. Hájek, M.; Matulová, N.; Votruba, I.; Holý, A.; Tloušťová, E.: "Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates" Biochem. Pharmacol. 2005, 70, 894-900.
4. Čapek, P.; Pohl, R.; Hocek, M.: "Synthesis of Enantiomerically Pure (Purin-6-yl)phenylalanines and Their Nucleosides, a Novel Type of Purine-Amino Acid Conjugates" J. Org. Chem. 2005, 70, 8001-8008.
3. Hocek, M.; Nauš, P.; Pohl, R.; Votruba, I.; Furman, P. A.; Tharnish, P. M.; Otto, M. J.: "Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides" J. Med. Chem. 2005, 48, 5869-5873.
2. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "The First Synthesis and Cytostatic Activity of Novel 6-(Fluoromethyl)purine Bases and Nucleosides" Org. Biomol. Chem. 2005, 3, 3001-3007.
1. Hocek, M.; Pohl, R.; Císařová, I.: "Highly Methylated Purines and Purinium Salts as Analogues of Heteromines" Eur. J. Org. Chem. 2005, 3026-3030.