2009

Hocková, D., Holý, A., Masojídková, M., Keough, D.T., Jersey, J.d., Guddat, L.W.:
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorganic and Medicinal Chemistry 17: 6218-6232, 2009.

Dračinský, M., Holý, A., Jansa, P., Kovačková, S., Budešinský, M.:
Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom.
European Journal of Organic Chemistry 24: 4117-4122, 2009.

Doláková, P., Dračínský, M., Fanfrlík, J., Holý, A.:
Synthesis of analogues of Acyclic nucleoside diphosphates containing a (phosphonomethyl)phosphanyl moiety and studies of their phosphorylation.
European Journal of Organic Chemistry 7: 1082-1092, 2009.

Doláková, P., Dračínský, M., Masojídková, M., Šolínová, V., Kašička, V., Holý, A.:
Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
European Journal of Medicinal Chemistry 44: 2408-2424, 2009.

Fernández-Botello, A., Holý, A., Moreno, V., Operschall, B.P., Sigel, H.:
Intramolecular p-p stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
Inorganica Chimica Acta 362: 799-810, 2009.

Šolínová, V., Kašička, V., Sázelová, P., Holý, A.:
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using b-CD as chiral selector.
Electrophoresis 30: 2245-2254 , 2009.

Keough, D.T., Hocková, D., Holý, A., Naesens, L.M.J., Skinner-Adams, T.S., De Jersey, J., Guddat, L.W.:
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutic.
Journal of Medicinal Chemistry 14: 4391-4399, 2009.

Konvalinka, J., Illnerová, H., Hobza, P., Hořejaší, V., Holý, A., Jungwirth, P., Pačes, V.:
Czech bibliometric system fosters mediocre research.
Nature 460: 1079, 2009.

Šála, M., Hřebabecký, H., Dračínský, M., Masojídková, M., De Palma, A.M., Neyts, J., Holý, A.:
Norbornane as the novel pseudoglycone moiety in nucleosides.
Tetrahedron 65: 9291-9299, 2009.

Krečmerová, M.; Holý, A.:
Syntheses of antivirals from the family of acyclic nucleoside phosphonates and their prodrugs.
PharmaChem: 6-9, 2009.

Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.:
Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase.
Tetrahedron 65: 8486-8492, 2009.

Otová, B.; Hrdý, J.; Votruba, I.; Holý, A.:
Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG.
Anticancer Res. 29: 1295-1302, 2009.

Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.:
Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol.
Collect. Czech. Chem. Commun. 74: 487-502, 2009.

Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.:
Synthesis of novel Racemic carbocyclic nucleoside analogue s derived from 4,8-dioxatricyclo[4.2.1.0^3,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.0^3,7]decane-10-methanol, c ompounds with activity against Coxsackie viruses.
Collect. Czech. Chem. Commun. 74: 469-485, 2009.

Řezáč, J., Fanfrlík, J., Salahub, D., Hobza, P.:
Semiempirical quantum chemical PM6 method augmented by dispersion and H-bonding correction terms reliably describes various types of noncovalent complexes.
Journal of Chemical Theory and Computation 5: 1749-1760, 2009.

Matějíček, P., Zedníky, J., Ušelová, K., Pleštil, J., Fanfrlík, J., Nykänen, A., Ruokolainen, J., Procházka, K.:
Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly ethylene oxide.
Macromolecules 42: 4829-4837, 2009.

Čeřovský, V., Budyšínský, M., Hovorka, O., Cvačka, J., Voburka, Z., Slaninová, J., Borovičková, L., Fučík, V., Bednárová, L., Votruba, I., Straka, J.:
Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).
ChemBioChem 10: 2089-2099, 2009.

Balšánek, V., Tichotová, L., Kuneš, J., Špulák, M., Pour, M., Votruba, I., Buchta, V.:
Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substance.
Collect. Czech. Chem. Commun. 74: 1161-1178, 2009.