2008
Vavrova, K.; Lorencova, K.; Novotny, J.; Holy, A.; Hrabalek, A.:
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir:
Influence of pH, ion-pairing and skin species.
European Journal of Pharmaceutics and Biopharmaceutics 70: 901-907, 2008.
Anzenbacherova, E.; Anzenbacher, P.; Zidek, Z.; Buchar, E.; Kmonickova, E.; Potmesil, P.; Nekvindova, J.; Veinlichova, A.; Holy, A.:
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and
its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Physiological Research (Prague, Czech Republic) 57: 761-767, 2008.
Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, M.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.:
Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential
resistance to anti-poxvirus drugs
J. Virol. 82: 12520-12534, 2008.
Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.:
Enzymatic polymerization of phosphonate nucleosides
ChemBioChem 9: 2883-2888, 2008.
Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.:
Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
Biochem. Pharmacol. 76: 997-1005, 2008.
Votruba, I.; Otová, B.; Holý, A.:
Acyklické nukleosidfosfonáty jako potenciální antineoplastika
Čas. Lék. čes. 147: 471-477, 2008.
Česnek, M.; Holý, A.; Masojídkova, M.; Kmoníčkova, E.; Zídek, Z.:
Synthesis of guanidino analogues of PMPDAP and their immunobiological activity
Bioorg. Med. Chem. 16: 965-980, 2008.
Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M.:
Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7
Org. Biomol. Chem. 6: 2852-2860, 2008.
Dračínský, M.; Krečmerová, M.; Holý, A.:
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy
Bioorg. Med. Chem. 16: 6778-6782, 2008.
Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.:
Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations
Bioorg. Med. Chem. 6: 2377-2387, 2008.
Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.:
Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di-
and C-trisaccharide analogues
Tetrahedron 64: 5200-5207, 2008.
Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.:
Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)-
and 6-(S-substituted sulfanylmethyl)purine nucleosides
Bioorg. Med. Chem. 16: 2329-2366, 2008.
Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlář, T.; Holý, A.:
Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing
N6-substituted purine acyclic nucleoside phosphonates
Collect. Czech. Chem. Commun. 73: 275-291, 2008.
Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.:
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine
phosphorylase
Bioorg. Med. Chem. Lett. 18: 1364-1367, 2008.
Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.:
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells
Biochem. Pharmacol. 75: 965-972, 2008.
Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.:
Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-,
and 6-[2-(dialkylamino)vinyl]purine nucleosides
Bioorg. Med. Chem. 16: 1400-1424, 2008.
Hřebabecký, H.; Dračínský, M.; Holý, A:
Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol
Collect. Czech. Chem. Commun. 73: 44-58, 2008.
Vávrová, K.; Lorencová, K.; Klimentová, J.; Novotný, J.; Holý, A.; Hrabálek, A.:
Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers
Eu. J. Pharm. Biopharm. 69: 597-604, 2008.