Staff

Name Kaiserová Helena
Position Postdoctoral Fellow

Dr. Helena Kaiserová

Helena Kaiserová, Ph.D.

Postdoctoral Fellow


Department of Nucleic Acid Chemistry
Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Phone: (+420) 220 183 114

 
Education
2003-2007 Ph.D. in Biochemistry, under supervision of Prof. Dr. E.Kvasničková at the Charles University in Prague - Faculty of Pharmacy.
1998-2003 M.Sc. in Pharmacy, under supervision of Prof. Dr. E.Kvasničková at the Charles University in Prague - Faculty of Pharmacy.
 
Experience
since 2007 Postdoctoral fellow with Prof. Dr. A.Holý at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague.
2005 Internship at the Department of Pharmacology and Toxicology, University of Maastricht - Prof. Dr. A.Bast.
 
Awards and Fellowhisps
2007 Prize of the Czech Minister of Education for excellent results and creativity during the postgraduate studies in the field of Pathobiochemistry and Xenobiochemistry.
2003 Dean's Prize for the graduate students with excellent results during their studies (Charles University, Faculty of Pharmacy).
2002 Czech Pharmaceutical Society's Prize for best student's research work: lecture "Contribution to the preclinical evaluation of new lipophilic iron chelators" presented at Student's Scientific Conference in Hradec Králové, April 2002.
 
Teaching
2004-2006 Practical training in General Biochemistry at the Charles University in Prague - Faculty of Pharmacy.
 
Research interest
Interactions of new analogues of nucleic acid components with protein kinase signalling (MAPK, PKB/Akt) and DNA polymerases.
 
List of papers

Kaiserová H., Šimůnek T., Štěrba M., den Hartog G.J.M., Schröterová L., Popelová O., Geršl V., Kvasničková E., Bast A.:
New iron chelators in anthracycline-induced cardiotoxicity.
Cardiovascular Toxicology 7 (2): 145-50, 2007.

Adamcová M., Šimůnek T., Kaiserová H., Popelová O., Štěrba M., Potáčová A., Vávrová J., Maláková J., Kvasničková E., Geršl V.:
In vitro and in vivo examination of Cardiac troponins as biochemical markers of anthracycline-induced cardiotoxicity.
Toxicology 237 (1-3): 218-28, 2007.

Kaiserová H., Šimůnek T., van der Vijgh W.J.F., Bast A., Kvasničková E.:
Flavonoids as protectants against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductases.
Biophysica Biochimica Acta 1772 (9): 1065-74, 2007.

Štěrba M., Popelová O., Šimůnek T., Mazurová Y., Potáčová A., Adamcová M., Guncova I., Kaiserová H., Palička V., Ponka P., Geršl V.:
Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH).
Toxicology 253 (3): 150-66, 2007.

Bast A., Kaiserová H., den Hartog G.J.M., Haenen G.R.M.M., van der Vijgh W.J.F.:
Protectors against doxorubicin-induced cardiotoxicity: Flavonoids.
Cell Biology and Toxicology 23 (1): 39-47, 2007.

Kaiserová H., den Hartog G.J.M., Šimůnek T., Schröterová L., Kvasničková E., Bast A.:
Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British Journal of Pharmacology 149 (7): 920-930, 2006.

Štěrba M., Popelová O., Šimůnek T., Mazurová Y., Potáčová A., Adamcová M., Kaiserová H., Ponka P., Geršl V.:
Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity.
Journal of Pharmacology and Experimental Therapy 319 (3): 1336-47, 2006.

Kaiserová H., Kvasničková E.:
Inhibition study of rabbit liver cytosolic reductases involved in daunorubicin toxication.
Journal of Enzyme Inhibition and Medicinal Chemistry 20 (5): 477-483, 2005.

Schröterová L., Kaiserová H., Baliharová V., Velík J., Geršl V., Kvasničková E.:
The effect of new lipophilic chelators on activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics. Studies in vitro.
Physiological Research 53 (6): 683-91, 2004.