11.1.2010 - Journal article: International Journal of Biochemistry and Cell Biology

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

To elucidate pro- and anti-oxidant action of MitoQ10, we studied its effects on HEP-G2 cell respiration, mitochondrial network morphology, and rates of superoxide release (above that neutralized by superoxide dismutase) to the mitochondrial matrix (Jm). Results suggest that MitoQ10 accepts electron prior to the rotenone-bound Q-site, and the Complex II reverse mode oxidizes MitoQ10H2 to regenerate MitoQ10. Consequently, MitoQ10 has a pro-oxidant role in intact cells, whereas it serves as an antioxidant when Complex I-derived superoxide generation is already elevated due to electron flow retardation.

Plecitá-Hlavatá L, Ježek J, Ježek P.: Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. International Journal of Biochemistry and Cell Biology 2009; 41:1697-1707. IF=4.178

 

Author: plecita@biomed.cas.cz

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28.5.2009 -  INVITATION
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21.5.2009 - Special Award for Dr. Pavel Flachs
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