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Seznam tyrosinových vazebných motivů

vstupní data od Karla

Yxx(L/I/V)-x(6-8)-Yxx(L/I/V) or
D/E-x(7-8)D/E-xx-Yxx(L/I)-x(7)-YxxL/I
ITAM
L/V/I/SxYxxL/I/V 
or unusual motif resembling ITIM 
(D/E)Y(S/T/A)E(I/V)(K/R)
ITIM (USUALLY 2 MOTIFS SPACED BY 26-31 AA)

In Siglecs - recruit SHP-1; similar to CD150 (SAP assoc?) (Varki Glycobiol 16:1R))
TxYxxV/I
ITSM - CD150 (Sidorenko NatImmunol 4:19)
TIpYxxV/I 
SH2 domain of SAP and EAT2 (Veillette NRI 6:56)
TVpYxxV/I
SH2 domain of SHIP1 (Veillette NRI 6:56)
YxxM
Triggers lipid kinase cascades
VDTYVEMRPV
PLC2 binding to M-CSF (The EMBO Journal Vol. 16 No. 19 pp. 5880-5893, 1997) NOT 100% sure, also PI3 kinase
DNDYIIPLPD
PLC1 binding to PDGFR (Mol. Cell. Biol., 1993, 133-143, Vol 13, No. 1)
PPSYLDVL
PLC1 binding to NGFR (J Biol Chem 269: 8901-89,1994)
   YXIP
Crk binding site (in Gab1, J Biol Chem, Vol. 275, Issue 15, 10772-10778, April 14, 2000)
   YXXP
Crk and C3G binding site in p130Cas, multiple, mostly YDVP and others, J Dermatol Sci 2000 Jun;23(2):75-86
SVDYVPM
PI3 kinase binding site in PDGFR (Mol. Cell. Biol., 01 1993, 133-143, Vol 13, No. 1)
DGGYMDM
PI3 kinase binding site in PDGFR (Mol. Cell. Biol., 01 1993, 133-143, Vol 13, No. 1)
   YVPM
PI3 kinase binding site (in Gab1, Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 12419-12424, November 1997)
NATYVNV
Gab1 binding site in c-Met (HGFR), (1997) J. Biol. Chem. 272, 20811-20819
DKVYENV
Grb2 bindig site in FAK, Nature 1994 Dec 22-29;372(6508):786-91
DPSYVNV
Grb2 bindig site in Shc (JBC, 272, 29046-29052, 1997)
VPEYINQ
Grb2 bindig site in EGFR (JBC, 272, 29046-29052, 1997)
NPEYLNT
Grb2 bindig site in EGFR (JBC, 272, 29046-29052, 1997)
NPEYLNT
Grb2 bindig site in erbB2 (JBC, 272, 29046-29052, 1997)
CELYENVGMYC
Artificial unphosphorylated(!) peptide bindig to Grb2 (JBC, 272, 29046-29052, 1997)
XLXY(M/F)X(F/M)
XLXYAXL
Shp-1 - N-terminal SH2 domain of  Shp-1 (Biochemistry 2000 Oct 31;39(43):13251-60)
(V/I/L)XYAX(L/V)
Shp-1 - C-terminal SH2 domain of  Shp-1 (Biochemistry 2000 Oct 31;39(43):13251-60)
YEMYVTV
Shp-2 binding to RCS (J. Biol. Chem, 10.1074/jbc.M103872200)
SSNYMAP
RasGAP binding site in PDGFR (Mol. Cell. Biol., 01 1993, 133-143, Vol 13, No. 1)
DDDYDDV
Slp-65 binding site in HPK1 (J Exp Med 2001 Aug 20;194(4):529-39)
NPXY
IRS3 - Interaction of PTB domain of IRS3 with insuline receptor, J Biol Chem 1999 May 21;274(21):15262-70
   Y[R/K]PQ
STAT-3 - In Lif-R, critical for STAT-3 activation, Leuk Lymphoma 2000 May;37(5-6):517-25
RAGYTTV
STAT3 binding to c-Ret (Oncogene 2001 Aug 30;20(38):5350-8)
DHIYTTQ
STAT3 binding to c-Ret (Oncogene 2001 Aug 30;20(38):5350-8)
   YXXQ
STAT3 (Oncogene 2001 Jun 14;20(27):3464-74)
NPVYATL
Internalisation of LRP (target for  chain of clathrin cp, J. Biol. Chem., Vol. 275, Issue 22, 17187-17194, June 2, 2000
HTGYEQF
Interaction with 4 (LAMP-2, J Biol Chem 2001 Apr 20;276(16):13145-13152)
   YTDIEM
VSV G protein, signal for export from ER Mol Biol Cell 2000 Jan;11(1):13-22
ERNYHTL
Lysozomal targeting of endolyn (very C-term.), Biochem J 2000 Jan 15;345 Pt 2:287-96
   YRKM
Intarnalisation of RSV env, Mol Cell Biol 2000 Jan;20(1):249-60
SPVYTSL
Necessary for capping of pseudorabies gE glycoprotein, Virology 1999 Jun 20;259(1):141-7
EGPYASL
Necessary for capping of pseudorabies gE glycoprotein, Virology 1999 Jun 20;259(1):141-7, necessary for internalisation, Virol 1999 Apr;73(4):2717-28
KIFYRTL
Internalisation motif in UL144 protein of HCMV, J Immunol 1999 Jun 15;162(12):6967-70
RQGYSPL
In HIV gp41, essential for targeting virions to basolateral membrane of MDCK, J Virol 1999 Jun;73(6):5010-7
ASDYQRL
TGN38 interaction with 2, FEBS Lett 1999 Feb 12;444(2-3):195-200, Syk binding - FEBS Lett 1997 Oct 13;416(1):27-9
RQGYSPL
Interaction of  TM env gp of HIV with  chains of clathrin, J Virol 1999 Feb;73(2):1350-61
RQGYRPV
Same in SIV
YPRYSLI
Same in HTLV-1
RRGYSRV
glycoprotein B [Human herpesvirus 3 VZV-Ellen] internalisation, Virology 2001 Jun 20;285(1):42-9
PPPPY
AIP4, a NEDD4 family E3 ubiquitin ligase (JBC. 280(40):34133-42)

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