Nicolas Joubert

Dr. Nicolas Joubert

e-mail: joubert@uochb.cas.cz

Born 17. 6. 1978 in Monaco.

Scientific CV:
1996-1999 Post secondary program leading to the nationwide competitive exam for admission to a graduate-level Engineering school (“Grande Ecole”), Lycée du Parc, Lyon, France
1999-2002 Diplôme d’ingénieur chimiste de l’ENSCCF (equivalent to master’s degree) in chemistry and chemical engineering awarded by the National School of Chemistry of Clermont Ferrand, France (supervisors : Prof. Yves Troin and Dr. Pierre Chalard)
2002 DEA (equivalent to master’s degree) in chemistry, with distinction, at the University Blaise Pascal of Clermont Ferrand, Aubiere, France (supervisors : Prof. Yves Troin)
2002-2005 Ph.D. studies in organic chemistry, with distinction, at the University of Orléans (supervisor : Prof. Luigi Agrofoglio)
2006-2008 Postdoctoral position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic

Awards:
2005 Best Oral Communication at the congress SECO 42 (Semaine d’Etude en Chimie Organique), Urrugne, France, May 2005. “Synthesis and biological evaluation of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides.”
2005 Best Poster at Sciences en Sologne 2005, Orléans, May 2005. “Organic chemistry and hepatitis C : first steps toward a new treatment of the disease.”

Participation on projects: New methodologies for the synthesis of C nucleosides for extension of genetic alphabet.

List of publications:

10.	Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
9.	Joubert, N.; Urban, M.; Pohl, R.; Hocek, M.: "Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C-2'-Deoxyribonucleosides" Synthesis 2008, 1918-1932.
8.	Joubert N.; Amblard, F.; Rapp, K. L.; Schinazi, R. F.; Agrofoglio, L.A.: "Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT" Tetrahedron 2008, 64, 4444-4452.
7.	Broggi, J.; Joubert N.; Aucagne, V; Berteina-Raboin, S; Diez-Gonzales, S.; Nolan, S.; Topalis, D.; Deville-Bonne, D.; Balzarini, J.; Neyts, J.; Andrei, G.; Snoeck, R.; Agrofoglio L.A.: "Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1391-1394.
6.	Broggi, J.; Joubert N.; Aucagne, V; Zevaco, T.; Berteina-Raboin, S; Nolan, S.; Agrofoglio L.A.: "Study of Different Copper (I) Catalysts for the "Click Chemistry" Approach to Carbanucleosides" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 779-783.
5.	Joubert, N.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Modular and Practical Synthesis of 6-Substituted Pyridin-3-yl C-Nucleosides" J. Org. Chem. 2007, 72, 6797-6805.
4.	Joubert, N.; Schinazi, R.F.; Agrofoglio, L.A.: "Efficient Pd(0)-catalyzed Synthesis of 1,2,3-Triazolo Carbanucleosides and their Analogs" Tetrahedron* 2005, 61, 11744-11750.
3.	Escuret V., Aucagne V., Joubert N., Durantel D., Rapp K. L., Schinazi R.F., Zoulim F., Agrofoglio L.A.: "5-Haloethynyl- and 5-(1,2-Dihalo)ethenyluracil Nucleosides: antiviral activities and cellular toxicities" Bioorg. Med. Chem.* 2005, 13, 6015-6024.
2.	Agrofoglio .L.A., Joubert N., Escuret V., Durantel D., Zoulim F. "The use of hcv replicon system for evaluation of new nucleoside analogs"* in Framing the Knowledge of Viral Hepatitis. R.F. Schinazi, Eds., ihl Press? Arlington MA, USA (2005).
1.	Agrofoglio L.A.; Aucagne V.; Amblard F.; Joubert N.; Zoulim F.; Escuret V.; Durantel D.; Trepo C. "Uridine Derivatives as Antiviral Drugs against a Flaviviridae, especially HCV"* Patent WO/2006/067606.