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Department of Cellular Neurophysiology

Head: Assoc. Prof. Alexandr Chvátal, PhD, DSc, MBA
E-mail: chvatalatbiomed [dot] cas [dot] cz
Phone: +420 241 062 670

 

Laboratory of Molecular Neurophysiology

Prof. Alexey Verkhratsky, MD, PhD, DSc | Head of Laboratory
E-mail: verkhratskyatbiomed [dot] cas [dot] cz
 
Prof. Alexey Verkhratsky, MD, PhD, DSc| Research Scientist
José Julio Rodríguez Arellano, PhD| Research Scientist
Govindan Dayanithi, PhD| Research Scientist
Magdaléna Kuliewicz, MSc| PhD Student
 

Laboratory of Neurobiology

Miroslava Anděrová, PhD | Head of Laboratory
E-mail: anderovaatbiomed [dot] cas [dot] cz
Phone: +420 241 062 050
 
Miroslava Anděrová, PhD| Research Scientist
Helena Neprašová, MD| PhD Student
Iva Prajerová, MSc| PhD Student
Jana Benešová, MSc| PhD Student
Olena Butenko, MSc| PhD Student
Pavel Honsa, MSc| PhD Student
Veronika Dlouhá| Undergraduate Student
Helena Pavlíková| Technician
Markéta Valová | Secretary

 

Research topics

The identification of the cellular and molecular mechanisms of integration in neural networks, through the characterisation of intercellular signalling pathways within neuronal-glial circuits and intracellular signalling mechanisms in neurones and glia under physiological and pathological conditions:
 
  • The role of glutamatergic and purinergic pathways in neuronal-glial signalling in the cortex, hippocampus and spinal cord with a specific emphasis on the glial NMDA and P2X receptors;
  • purinoreceptor-mediated signalling in neurones and glia in the context of their role in sensory transduction and in acute and chronic pain;
  • glial representation of TRP channels and their role in glial signalling;
  • ion channels and Ca2+ signalling cascades in various types of neural cells at different stages of differentiation;
  • in vivo imaging of neuronal-glial circuits under physiological and pathophysiological conditions;
  • calcium signalling cascades in neurodegeneration and Alzheimer’s disease, in particular; the morphology and physiology of glia during normal brain ageing.
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