Department of Molecular Embryology
Head: Assoc. Prof. Aleš Hampl, DVM, PhD
Address: Kamenice 5, 625 00 Brno, Czech Republic
E-mail: ahampl
med [dot] muni [dot] cz
med [dot] muni [dot] czPhone: +420 549 493 514
Assoc. Prof. Aleš Hampl, DVM, PhD | Research Scientist
Assoc. Prof. Petr Dvořák, PhD | Research Scientist
Vladimir Rotrekl, PhD | Research Scientist
Monika Nálezková, MSc | PhD Student
Dáša Doležalová, MSc | PhD Student
Tomáš Bárta, MSc | PhD Student
Vladimír Vinarský, Bc | Graduate Student
Martina Vodinská, DVM | Research Assistant
Klára Koudelková, MD | Research Assistant
Iva Hanáková, Bc | Technician
Research topics
Historically, research in the department has focused on studying cells with pluripotent properties, including developing gametes and cells of embryonal origin – embryonal carcinoma cells and embryonic stem cells. The department is the first and only laboratory in the Czech Republic where cell lines (embryonic stem cells – ESC) were established from human blastocyst-stage embryos in 2003.
Colony of undifferentiated human embryonic stem cells (line CCTL14 established in the department) growing on a feeder layer of mouse embryonic fibroblasts.
Since then, the major focus of the department has been on various aspects of the biology of these unique primitive cells, which, because of their potential to differentiate into all specialized cell types of the adult body, represent unprecedented promise for new-age medicine.
Tumor suppressor protein p53 is highly expressed in the nuclei of some cells in a colony of human embryonic stem cells cultured in vitro. The red color visualizes p53 protein inside the cell nuclei.
