2009

Hocková, D., Holý, A., Masojídková, M., Keough, D.T., Jersey, J.d., Guddat, L.W.:
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorganic and Medicinal Chemistry 17: 6218-6232, 2009.

Dračinský, M., Holý, A., Jansa, P., Kovačková, S., Budešinský, M.:
Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom.
European Journal of Organic Chemistry 24: 4117-4122, 2009.

Doláková, P., Dračínský, M., Fanfrlík, J., Holý, A.:
Synthesis of analogues of Acyclic nucleoside diphosphates containing a (phosphonomethyl)phosphanyl moiety and studies of their phosphorylation.
European Journal of Organic Chemistry 7: 1082-1092, 2009.

Doláková, P., Dračínský, M., Masojídková, M., Šolínová, V., Kašička, V., Holý, A.:
Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
European Journal of Medicinal Chemistry 44: 2408-2424, 2009.

Fernández-Botello, A., Holý, A., Moreno, V., Operschall, B.P., Sigel, H.:
Intramolecular p-p stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
Inorganica Chimica Acta 362: 799-810, 2009.

Šolínová, V., Kašička, V., Sázelová, P., Holý, A.:
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using b-CD as chiral selector.
Electrophoresis 30: 2245-2254 , 2009.

Keough, D.T., Hocková, D., Holý, A., Naesens, L.M.J., Skinner-Adams, T.S., De Jersey, J., Guddat, L.W.:
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutic.
Journal of Medicinal Chemistry 14: 4391-4399, 2009.

Konvalinka, J., Illnerová, H., Hobza, P., Hořejaší, V., Holý, A., Jungwirth, P., Pačes, V.:
Czech bibliometric system fosters mediocre research.
Nature 460: 1079, 2009.

Šála, M., Hřebabecký, H., Dračínský, M., Masojídková, M., De Palma, A.M., Neyts, J., Holý, A.:
Norbornane as the novel pseudoglycone moiety in nucleosides.
Tetrahedron 65: 9291-9299, 2009.

Krečmerová, M.; Holý, A.:
Syntheses of antivirals from the family of acyclic nucleoside phosphonates and their prodrugs.
PharmaChem: 6-9, 2009.

Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.:
Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase.
Tetrahedron 65: 8486-8492, 2009.

Otová, B.; Hrdý, J.; Votruba, I.; Holý, A.:
Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG.
Anticancer Res. 29: 1295-1302, 2009.

Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.:
Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol.
Collect. Czech. Chem. Commun. 74: 487-502, 2009.

Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.:
Synthesis of novel Racemic carbocyclic nucleoside analogue s derived from 4,8-dioxatricyclo[4.2.1.0^3,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.0^3,7]decane-10-methanol, c ompounds with activity against Coxsackie viruses.
Collect. Czech. Chem. Commun. 74: 469-485, 2009.

Řezáč, J., Fanfrlík, J., Salahub, D., Hobza, P.:
Semiempirical quantum chemical PM6 method augmented by dispersion and H-bonding correction terms reliably describes various types of noncovalent complexes.
Journal of Chemical Theory and Computation 5: 1749-1760, 2009.

Matějíček, P., Zedníky, J., Ušelová, K., Pleštil, J., Fanfrlík, J., Nykänen, A., Ruokolainen, J., Procházka, K.:
Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly ethylene oxide.
Macromolecules 42: 4829-4837, 2009.

Čeřovský, V., Budyšínský, M., Hovorka, O., Cvačka, J., Voburka, Z., Slaninová, J., Borovičková, L., Fučík, V., Bednárová, L., Votruba, I., Straka, J.:
Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).
ChemBioChem 10: 2089-2099, 2009.

Balšánek, V., Tichotová, L., Kuneš, J., Špulák, M., Pour, M., Votruba, I., Buchta, V.:
Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substance.
Collect. Czech. Chem. Commun. 74: 1161-1178, 2009.

Řezáčová P., Pokorná J., Brynda J., Kožíšek M., Cígler P., Lepšík M., Fanfrlik J., Řezáč J., Šašková K. G., Sieglová I., Plešek J., Sícha V., Gruener B., Oberwinkler H., Sedláček J., Kraeusslich H., Hobza P., Král V., Konvalinka J.:
Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes.
Journal of Medicinal Chemistry 52 (22): 7132-7141, 2009.