2005

Chalupová S., Holý A., Masojídková M.:
Synthesis of N4-substituted derivatives of 1-[2- (phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N4-substituted derivatives of cidofovir.
Collection of Czechoslovak Chemical Communications 12 (70): 2066-2074, 2005.

Dal Pozzo F., Andrei G., Holý A., Van Den Oord J., Scagliarini A., De Clercq E., Snoeck R.:
Activities of acyclic nucleoside phosphonates against orf virus in human and ovine cell monolayers and organotypic ovine raft cultures.
Antimicrobial Agents and Chemotherapy 12 (49): 4843-4852, 2005.

Smee D.F., Wandersee M.K., Bailey K.W., Hostetler K.Y., Holý A., Sidwell R.W.:
Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.
Antiviral Chemistry and Chemotherapy 3 (16): 203-211, 2005.

De Clercq E., Holý A.:
Case history: Acyclic nucleoside phosphonates: A key class of antiviral drugs.
Nature Reviews Drug Discovery 11 (4): 928-940, 2005.

De Clercq E., Andrei G., Balzarini J., Leyssen P., Naesens L., Neyts J., Pannecouque C., Snoeck R., Ying C., Hocková D., Holý A.:
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, Nucleotides and Nucleic Acids 5-7 (24): 331-341, 2005.

Chalupová S., Holý A., Masojídková M.:
Synthesis of some N4-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir).
Collection of Czechoslovak Chemical Communications 12 (70): 2053-2065, 2005.

Šilhár P., Pohl R., Votruba I., Hocek M.:
Synthesis of 2-substituted 6-(hydroxymethyl)purine bases and nucleosides.
Collection of Czechoslovak Chemical Communications 10 (70): 1669-1695, 2005.

Hájek M., Matulová N., Votruba I., Holý A., Tloušťová E.:
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates.
Biochemical Pharmacology 6 (70): 894-900, 2005.

Hocek M., Naus P., Pohl R., Votruba I., Furman P.A., Tharnish P.M., Otto M.J.:
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.
Journal of Medicinal Chemistry 18 (48): 5869-5873, 2005.

Pomeisl K., Pohl R., Holý A., Votruba I.:
Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts.
Collection of Czechoslovak Chemical Communications 9 (70): 1465-1481, 2005.

Šilhár P., Pohl R., Votruba I., Hocek M.:
The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.
Organic and Biomolecular Chemistry 16 (3): 3001-3007, 2005.

Fernandez-Botello A., Griesser R., Holý A., Moreno V., Sigel H.:
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy) ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution.
Inorganic Chemistry 14 (44): 5104-5117, 2005.

Votruba I., Pomeisl K., Tloušťová E., Holý A., Otová B.:
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.
Biochemical Pharmacology 10 (69): 1517-1521, 2005.

Česnek M., Holý A., Masojídková M., Zídek Z.:
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6- guanidinopurines and their influence on the NO-production in macrophages.
Bioorganic and Medicinal Chemistry 8 (13): 2917-2926, 2005.

Hřebabecký H., Masojídková M., Holý A.:
Synthesis of novel conformationally locked carbocyclic nucleosides derived from 5,5- and 6,6-bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol.
Collection of Czechoslovak Chemical Communications 4 (70): 519-538, 2005.

Doláková P., Holý A., Zídek Z., Masojídková M., Kmoničková E.:
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorganic and Medicinal Chemistry 7 (13): 2349-2354, 2005.

Naesens L., Lenaerts L., Andrei G., Snoeck R., Van Beers D., Holý A., Balzarini J., De Clercq E.:
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Antimicrobial Agents and Chemotherapy 3 (49): 1010-1016, 2005.

Turek P., Kotora M., Hocek M., Votruba I.:
Novel method for preparation of highly substituted 6-arylpurines by reactions of 6-alkynylpurines with zirconacyclopentadienes.
Collection of Czechoslovak Chemical Communications 3 (70): 339-349, 2005.

Ying C., Holý A., Hocková D., Havlas Z., De Clercq E., Neyts J.:
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
Antimicrobial Agents and Chemotherapy 3 (49): 1177-1180, 2005.

Jacobson K.A., Ohno M., Duong H.T., Kim S.-K., Tchilibon S., Česnek M., Holý A., Gao Z.-G.:
A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.
Chemistry and Biology 2 (12): 237-247, 2005.

Hocková D., Masojídková M., Holý A.:
Sonogashira cross-coupling in the synthesis of acyclic nucleoside phosphonates: Preparation of 6-[(phosphonomethoxy)alkynyl]- and 6-[(phosphonomethoxy)alkyl]pyrimidines.
Collection of Czechoslovak Chemical Communications 2 (70): 247-258, 2005.

Hřebabecký H., Masojídková M., Holý A.:
Synthesis of racemic 9-(6- and 2,6-substituted 9H-purin-9-yl)-5- oxatricyclo[4.2.1.03,7]nonane-3-methanols, novel conformationally locked carbocyclic nucleosides.
Collection of Czechoslovak Chemical Communications 1 (70): 103-123, 2005.