Domů — Výzkum — Laboratoř inženýrství vazebných proteinů
Laboratoř inženýrství vazebných proteinů
Head: Ing.Peter Šebo, CSc.
Milan Kuchař, PhD
Ing. Hana Petroková, PhD
Lada Biedermannová, PhD
Ing. Bohdan Schneider, CSc.
Petr Malý, PhD
Ing. Jiří Černý, PhD.
Laboratoř byla založena v březnu 2007.
Research topics
Design and rational improvement of high-affinity-binding recombinant ligand proteins for use in applications in which antibodies fail.
Recent papers
Crystallization and preliminary X-ray diffraction analysis of mouse galectin-4 N-terminal carbohydrate recognition domain in complex with lactose. 1;64(Pt 7):665-7.Acta Crystallogr Sect F Struct Biol Cryst Commun. Krejčiříková V, Fábry M, Marková V, Malý P, Řezáčová P, Brynda J. (2008 Jun).
Tartz, S., Rüssmann, H., Kamanova, J., Sebo, P., Sturm, A., Heussler, V., Fleischer, B. and Jacobs, T. (2008). Complete Protection against P. berghei Malaria upon Heterologous Prime/Boost Immunization using Recombinant Salmonella and Bordetella Adenylate Cyclase Vaccines. Vaccine 26, 5935-5943.
Kamanova, J., Kofronova, O., Masin, J., Genth, H., Vojtova, J., Linhartova, I., Benada, O., Just, I. and P. Sebo* (2008). Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling. J. Immunol. 181, 5587-5597.
Sadilkova, L., Osicka, R., Šulc, M., Linhartova, I., Novak, P. and Šebo, P. (2008). Single-step affinity purification of recombinant proteins using a self-excising module from Neisseria meningitidis FrpC. Protein Sci. 17, 1834-1843.
Morova, J., Osicka, R.*, Masin, J. and P. Sebo (2008). RTX Cytotoxins Recognize β2 Integrin Receptors through N‑linked Oligosaccharides. Proc. Natl. Acad. Sci. USA 105, 5355-5360.
Sewald. X., Gebert-Vogl, B., Prassl, S., Weiss, E., Fabbri, M., Osicka, R. Schiemann, M., Busch, D.H., Semmrich, M., Holzmann, B., Sebo, P. and R. Haas* (2008). CD18 is the T-lymphocyte receptor of the Helicobacter pylori Vacuolating Cytotoxin. Cell Host & Microbe 3, 20-29.
Knapp, O., Maier, E., Masin, J., Sebo, P. and R. Benz*(2007).
Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: Role of voltage and pH. BBA Biomembr.77, 260-269.