From 26th April 2010 to 21st May 2010 in the Institute gallery of IMC AS CR, an exhibition Martin Janíček:Voice calligraphy takes place
77 PMM Conference Polymers in Medicine is to be held on 8.-12. July 2012.
74 PMM conference Contemporary Ways to Tailor-made Polymers: 18 - 22 July 2010
| Supervisor ((Consultant)) | Michal Pechar, PhD |
|---|---|
| Topic | Hybrid macromolecular systems for targeted therapy and diagnostics: Specific attachment of biologically active proteins and peptides to hydrophilic polymers |
| Annotation | Connection of synthetic and natural macromolecules can lead to sophisticated materials with brand new properties. Some polymer systems are utilized for controlled release and targeted delivery of drugs. Hydrophilic synthetic polymers bearing various biologically active peptides and proteins will be designed and synthesized. The peptides and proteins (e.g. antibodies or antibody fragments) will be used as targeting ligands enabling increased accumulation of (anti-tumor) drugs in the site of desired therapeutic effect. Various ligation methods preserving the biological activity of the targeting ligands will be studied. Interaction of two peptides forming an intermolecular coiled coil motif will be utilized for attachment of recombinant proteins to polymers. The polymer carriers prepared in the project will be based mostly on copolymers of N-(2-hydroxypropyl)methacrylamide or poly(ethylene oxide). Physico-chemical methods such as liquid chromatography, mass spectroscopy, light scattering, circular dichroism, NMR of solution and solid phase will be used for characterization of the hybrid polymers. The biological evaluation of the systems will be performed in a collaborating biological |
Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410
