From 26th April 2010 to 21st May 2010 in the Institute gallery of IMC AS CR, an exhibition Martin Janíček:Voice calligraphy takes place
77 PMM Conference Polymers in Medicine is to be held on 8.-12. July 2012.
74 PMM conference Contemporary Ways to Tailor-made Polymers: 18 - 22 July 2010
| Supervisor ((Consultant)) | Vladimír Šubr, PhD |
|---|---|
| Topic | Polymer drug conjugates overcoming multidrug resistance. |
| Annotation | Low efficacy or failure of anticancer treatment is often associated with overexpression of transporters causing the development of a multidrug resistance (MDR). Possibility how to overcome the MDR is usage of polymer carriers enabling simultaneously transport biologically active compound (drug) and MDR transporter inhibitors to desired location and there by controlled way release the active drug and simultaneously inhibit the MDR transporters. The aim of a thesis is a design of new polymer carriers bearing biologically active compound and inhibitors, their synthesis and study of relationship between structure, physico-chemical and biological properties. The main focus of the thesis will be in organic and polymer synthesis and in cooperation with biologist testing these compounds. |
Institute of Macromolecular Chemistry AS CR, v.v.i.
Heyrovského nám. 2
CZ-162 06 Praha 6
Czech Republic
phone:+420 296 809 111
fax:+420 296 809 410
