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INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY (IUPAC)

TISSUE ENGINEERING SOCIETY INTERNATIONAL (TESI)

CZECH CHEMICAL SOCIETY

43rd Microsymposium of P.M.M.

POLYMER BIOMATERIALS: BIOMIMETIC AND BIOANALOGOUS SYSTEMS

PRAGUE, 11 - 15^th JULY 2004

SECOND CIRCULAR

INSTITUTE OF MACROMOLECULAR CHEMISTRY

ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

PRAGUE, CZECH REPUBLIC

Contents

• PROGRAMME
  • SCOPE
  • TOPICS
  • SESSIONS
  • LANGUAGE
  • PRESENTATION FACILITIES
  • MAIN LECTURES
  • SPECIAL LECTURES
  • POSTER COMMUNICATIONS
  • PUBLICATION OF SUMMARIES
    • Preparation of summaries
  • PUBLICATION OF PAPERS
  • DEADLINES
• PRELIMINARY SCHEDULE
• ACCOMPANYING PERSONS PROGRAMME
  • EVENTS
  • BOOKING

• GENERAL  INFORMATION
  • REGISTRATION
    • Final registration
    • Registration fees
    • Remittance of fees
    • Cancellation
  • ACCOMMODATION
    • Accommodation in hotels
    • Accommodation in the Hvězda student dormitory
  • APPLICATION FOR VISAS
  • INSURANCE
• ON  ARRIVAL  IN  PRAGUE
  • CURRENCY, EXCHANGE, PAYMENT CARDS
  • TRANSPORT
    • Public transport
    • How to reach the Institute of Macromolecular Chemistry (Prague 6, Petřiny area)
    • How to reach the Hvězda student dormitory (Prague 6, Petřiny area)
    • Taxi
  • REFRESHMENTS AND LUNCHES
• CORRESPONDENCE

CONTENTS

PRAGUE MEETINGS ON MACROMOLECULES
66th meeting - 43rd Microsymposium

under the auspices of the

INTERNATIONAL UNION
OF PURE AND APPLIED CHEMISTRY

Macromolecular Division

Organized by the

INSTITUTE OF MACROMOLECULAR CHEMISTRY
ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Address:

Contact:

International Advisory Board

D. Cohn (Israel), Y. Doi (Japan), P.C. Johnson (USA), C. Migliaresi (Italy),
A.G. Mikos (USA), C. Werner (Germany), S. Zhang (USA)

Microsymposium Chairman

František Rypáček

(Czech Republic)

PROGRAMME

SCOPE

The 43rd microsymposium is aimed at bringing together experts with various backgrounds, both from academia and industry, who wish to benefit from combining approaches of polymer chemistry, surface chemistry, and materials science on one hand and biochemistry, molecular and cell biology, and medicine on the other.

Through incorporation of biomimetic structures into synthetic polymers and their surfaces, new advanced biomaterials for biology and medicine can be developed and, vice versa, by using bioanalogous processes and biosynthetic pathways, unique polymers and materials can be produced, applicable not only in biomedical but also in various other fields.

TOPICS

• Chemistry, physics and biology of biomimetic structures on polymer surfaces and their interactions with biomolecules, cells and components of living tissues. Molecular recognition, surface patterning, biofunctional assemblies, biosensing and bio-hybrid systems.
• Polymer biomaterials as scaffolds for cell therapy, tissue regeneration and tissue engineering. Synthesis, processing, and functionalization.
• Bioanalogous processes in the synthesis of polymers and development of bioanalogous polymer systems.

SESSIONS

All sessions will be held in the Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic, Praha 6, Heyrovského nám. 2.

The scientific programme consists of invited main lectures of 40 min and additional 10 min for discussion, special lectures of 20 min and additional 5 min for discussion, and two poster sessions.

LANGUAGE

English is the working language of the Microsymposium; no translation will be provided. All materials for publication must be submitted in English.

PRESENTATION FACILITIES

Data-Video-Projector (XGA) connected to a local PC will be available. Following media can be used for transfer of data: FDD 3.5", CD, DVD-R, USB-Flash. Other supported inputs are via: PC MCIA, IEEE 1394 ports, 4-in-1 Card Reader-Multimedia Card, Secure Digital, Memory Stick, Smart Media, or from VHS. No connection of private notebooks or laptops will be allowed.

In addition, overhead projector, 5 x 5 cm slide projector (the slide projector does not function properly with slides thicker than 2.5 mm), and blackboard will be available for lectures and discussions.

MAIN LECTURES

The following scientists have agreed to present the main lectures:

D.C. Gajdusek (Nobel Prize winner) opening lecture
title to be given

T.J. Deming (University of California Santa Barbara, CA, USA)
Synthesis and Properties of Amphiphilic Block Copolypeptides

D.E. Discher (University of Pennsylvania, Philadelphia, PA, USA)
title to be given

Y. Doi (RIKEN-Institute of Physical and Chemical Research, Saitama, Japan)
Biosynthesis and Material Design of Biodegradable Polyesters

D.W. Hutmacher (National University of Singapore, Singapore)
Design, Fabrication, Characterization and Biological Function of Polymer Scaffolds in Holistic Tissue Engineering Platforms

A.G. Mikos (Rice University, Houston, TX, USA)
Biodegradable, In-situ Crosslinkable Hydrogels as Injectable Carriers for Cell and Drug Delivery in Orthopaedics

S. Zhang (Massachusetts Institute of Technology, Cambridge, MA, USA)
Fabrication of Novel Materials through Biomolecular Self-assembly

SPECIAL LECTURES

The following tentative titles of special lectures have been accepted:

A-C. Albertsson (Royal Institute of Technology, Stockholm, Sweden)
Nanopatterned Scaffolds from Degradable Polyesters

D. Bakoš (Slovak Technical University, Bratislava, Slovakia):
Polyelectrolyte Type Scaffolds from Natural Polymers

R. Barbucci (University of Siena, Siena, Italy):
Sub-microarchitecture Scaffolds for Tissue Engineering Applications

H. Baumann (Institute for Technical Chemistry and Macromolecular Chemistry, Aachen, Germany):
Recent Developments of Hemocompatible Biomaterials for Flow Systems Resulting in Reduced Platelet and Plasma Proteins Adhesion

F. Branda (University of Naples Federico II, Naples, Italy):
Hydroxyapatite-Coated Hydrogels by Biomimetic Methods

Xuesi Chen (Institute of Applied Chemistry, Changchun, China):
Design and Synthesis of Biodegradable Aliphatic Ester and Amino-acid Block Copolymers

D. Cohn (Hebrew University of Jerusalem, Jerusalem, Israel):
Injectable Polymeric Systems as the Basis for In situ Generated Implants

M. El Fray (Technical University of Szcecin, Szcecin, Poland):
Preparation and In vitro Studies of Novel Hybrid Materials

A. Göpferich (University of Regensburg, Regensburg, Germany)
Biomimetic Polymers in Pharmaceutical and Biomedical Sciences

D. Mantovani (Laval University, Quebec, Canada):
Development of a Hybrid and Mechano-compatible Polymer Structure to Scaffold Vascular Tissue Regeneration

C. Migliaresi (University of Trento, Trento, Italy):
Silk-fibroin-based Gels for Tissue Augmentation

F. Mücklich (Saarland University, Saarbrücken, Germany):
In vitro Cell Response to Polymer Surface Micropatterned by Laser Interference

J. Reguera (University of Valladolid, Valladolid, Spain):
Design and Bioproduction of a Recombinant Elastin-like Protein Polymer Containing Endothelial Cell Adhesion Sequences as Advanced Matrix for Tissue Engineering

J. Rodríguez-Hernández (Laboratory of Organic and Polymer Chemistry, ENSCBP, Pessac, France):
Self-assembly and Stabilization of Peptide-containing Block Copolymers

K. Smetana (Charles University, Prague, Czech Republic):
Cell Therapy of Skin Lesions

H. Solak (Paul Scherrer Institute, Villigen, Switzerland):
Creation of Patterned Polymer Films via Deposition on Chemically Modified Templates

J.R. Venugopal (National University of Singapore, Singapore):
Electrospun Natural and Synthetic Polymer Nanofibers for Tissue Engineered Skin

T. Wada (Osaka University, Osaka, Japan):
Peptide Ribonucleic acids (PRNA). A novel Strategy for Active Control of DNA Recognition through Borate ester Formation

C. Werner (Institute of Polymer Research, Dresden, Germany):
Physicochemical Modulation of Bioactive Molecules Attached to Maleic Anhydride Copolymer Films

T. Yong (National University of Singapore, Singapore):
Effects of Fluorescent Probe CMFDA and GFP on Cell Adhesion Proteins of Cells Cultured on Synthetic Polymer Nanofibers

For further information on the main and special lectures, please visit our web site at http://www.imc.cas.cz/sympo/43micros/index.html

POSTER COMMUNICATIONS

Contributions covering unpublished results related to the programme topics may be presented as posters. The number of poster communications is not limited but every poster communication is to be registered for presentation on the Registration Form; the registered poster communication is automatically accepted if the author's participation fee has been remitted.

Boards for mounting poster materials are 120 cm high and 150 cm wide. Both pins and an adhesive tape can be used for mounting posters on boards. The material for mounting posters will be provided.

PUBLICATION OF SUMMARIES

Summaries of main and special lectures and all registered poster communications will be published in the Programme Booklet provided their camera-ready texts have reached the P.M.M. Secretariat by 30 April 2004, either on diskettes, by e-mail, or using upload through Microsymposium website. Files in RTF or Microsoft Word files are most suitable, files in PDF or as GIF pictures with resolution 600 dpi can also be accepted.

It is useful to use file names derived from the name of the participant (if you register with WWW form and upload your abstract, the file is renamed automatically). You may also send a hard copy of the summary by mail; facsimiles cannot be accepted.

The P.M.M. Secretariat will confirm the receipt of the summaries of all registered participants. Summaries of unregistered participants will be neither confirmed nor published or returned.

Summaries, except for their headings, will be printed without editing.

The Programme Booklet will be available at the Registration Desk.

Preparation of summaries

Summaries should not exceed one page of the A4 size.

A sample of an abstract is enclosed at the end of the Circular. It is also available at http://www.imc.cas.cz/sympo/ginfo/summary.rtf in RTF format.

Summaries with the format not corresponding to that of the sample will not be accepted.

PUBLICATION OF PAPERS

The Editor of Biomacromolecules (ACS journal) agreed to publish the collected papers, based on the communications to this symposium. Biomacromolecules is an interdisciplinary journal, publishing original papers focused on the research occurring at the interface of polymer science and biological sciences. The emphasis is on fundamental and applied papers that integrate knowledge in both polymer science and the biological sciences. The participants, namely the presenters of main and special lectures, are encouraged to publish their contribution in this esteemed scientific journal.

The authors should follow the Author Guidelines of Biomacromolecules in preparation of their manuscripts. Complete instructions to authors can be found at the Biomacromolecules home page at http://pubs.acs.org/biomac . All papers to be published will be reviewed by a standard peer review process. In order to secure timely publishing in a collective issue, the manuscript, prepared according to the above guidelines, should be submitted either as a hard copy, accompanied by the electronic file on diskette or CD, during the symposium at the registration desk, or directly to the journal using regular manuscript submission procedure of Biomacromolecules. The final deadline for manuscript submission (to be considered for this symposium issue) is July 31, 2004.

DEADLINES

For detailed information, see General Information p.14

PRELIMINARY SCHEDULE

Sunday, 11 July

All the following sessions (Monday through Thursday) take place in the Institute of Macromolecular Chemistry, Praha 6, Heyrovského nám. 2.

Monday, 12 July

Tuesday, 13 July

Wednesday, 14 July

Thursday, 15 July

ACCOMPANYING PERSONS PROGRAMME

EVENTS

Sightseeing and visits will be guided.

Monday, 12 July

Tuesday, 13 July

Wednesday, 14 July

Thursday, 15 July

BOOKING

For booking and payment, see General Information.

Unregistered accompanying persons and children cannot participate in the scheduled events, nor are they provided with lunch tickets.

GENERAL INFORMATION

REGISTRATION

Final registration

Any person wishing to attend the Microsymposium (including invited speakers) must submit the enclosed Registration Form to the P.M.M. Secretariat by 30 April 2004.

The Registration Form (unless submitted using the WWW form) should be completed in three copies: any item not filled in means that the particular reservation is not requested. Please return the white and green copies and keep the yellow one; the receipt of your final registration will be confirmed on the green copy sent back to you. The confirmation of Registration Form means only that your registration is accepted; it is not a receipt of payment (see Remittance of fees).

Please note that the title of any contribution should be definitive and identical with the summary heading (see p. 10). The summary of a contribution does not replace the final registration. Registration Form is also available at http://www.imc.cas.cz/sympo/r43ms.htm

Registration fees

The fees can be paid in any convertible currency but the total must be equivalent to the sum specified in Euro (EUR):

The registration fee for an active participant includes microsymposium materials, admission to all sessions, refreshments, four lunches, and participation in the welcome reception and farewell drink.

The registration fee for an accompanying person includes participation in events according to the Accompanying Persons Programme, in the welcome reception and farewell drink.

None of the registration fees includes the excursion with informal dinner on Wednesday.

 * The participant is requested to give the number of his/her IUPAC Affiliate Membership card valid in 2004 in his/her Registration Form and show the card during on-site registration.

** Student-rate registration is available for students who can prove their full-time student status by enclosing a statement from their university or institute with the Registration Form.

Remittance of fees

Please order your bank to transfer the respective amount or enclose a cheque payable to the account "ústav makromolekulární chemie AV ČR, Heyrovského nám. 2, 162 06  Praha 6, No. 478387443/0300", variable symbol 438140, with the Československá obchodní banka (address: Na příkopě 14, CZ-115 20 Praha 1, Czech Republic; swift: CEKOCZPP) together with your Registration Form. If you pay by bank transfer, please enclose a copy of your bank draft with your Registration Form. The P.M.M. Secretariat will acknowledge payments by mailing receipts.

The P.M.M. Secretariat is able to accept mail order payments with embossed Eurocard/Mastercard or VISA cards. Please fill in the form (available at http://www.imc.cas.cz/sympo/mailord.htm or http://www.imc.cas.cz/sympo/mailord.pdf or sent on request), sign it and send to the address of the P.M.M. Secretariat by airmail. The receipt of payment will be confirmed.

Remittance of fees is to be made by 30 April 2004. If a cheque is delivered to the P.M.M. Secretariat or payment recorded at the bank in Prague after 15 May 2004 (late payment), the higher rate of registration fees will come into effect and possible arrears will have to be cleared at the Registration Desk. On-site cash payment of a registration fee as a late payment may be accepted only exceptionally and after preliminary agreement of the organizers; without such agreement, the applicant could not be included in the list of participants in the Programme Booklet.

Cancellation

In the event of cancellation of participation, a full refund of the fees paid (less an administrative bank tax) will be made if the P.M.M. Secretariat receives notification before 15 June 2004. Only 75 % of the fees paid will be refunded if cancellation is received after 14 June but before 1 July 2004. In any case, please inform the P.M.M. Secretariat where to return the payment (bank, address, and account No.). Refunds will not be issued for cancellations received after 30 June 2004.

ACCOMMODATION

Accommodation in hotels

Participants who prefer accommodation in a hotel or those who could not book the student dormitory due to their late order should make hotel reservation through travel or accommodation agencies. Due to good experience and long-term cooperation, we recommend the Congress Agency EKU (CZ-110 00 Praha 1, Vodičkova 17, tel./fax +420-224 947 589, e-mail info@eku.cz, http://www.eku.cz ).

The organizers and the P.M.M. Secretariat neither make hotel reservations nor mediate contacts with travel and accommodation agencies.

Accommodation in the student dormitory

Participants wishing to lodge in the Hvězda student dormitory (Praha 6, Zvoníčkova 5 - ca. 600 m from the Institute) should indicate their reservation requirement in the Registration Form. In the dormitory, double rooms are available. If you wish to share a room with a certain person, please give the name of your roommate in the Registration Form. If no name is given, the P.M.M. Secretariat will feel free to make any occupation. As the number of rooms is limited, they will be allotted on a "first-come, first-served" basis.

Accommodation charges (including breakfast) are to be paid together with other Microsymposium fees using cheques or money orders (see Remittance of fees, p.15):

• 15 EUR per night per person in a shared double room

On the departure day, the room must be cleared at noon at the latest; after that time, a full charge for the day must be paid.

APPLICATION FOR VISAS

A valid passport is required for entry into the Czech Republic. The visas are valid for three months from the date of issue; please note that your visa must be valid until the end of your stay in the Czech Republic. Visas are not required if participants come from countries having a visa-free agreement with the Czech Republic.

IUPAC sponsorship implies that entry visas will be granted to all bona fide scientists provided application is made not less than three months in advance. If a visa is not granted one month before the Microsymposium, the IUPAC Secretariat should be immediately notified by the applicant (phone: +1-919-4858 701, fax: +1-919-4858 706, e-mail: secretariat@iupac.org).

INSURANCE

Participants are advised to arrange health and travel insurance and whatever insurance they consider necessary prior to departure. The registration fees do not include provision of any insurance. Neither organizing institutions nor their representatives assume responsibility or liability for personal accident and loss or damage to belongings however caused.

ON ARRIVAL IN PRAGUE

CURRENCY, EXCHANGE, PAYMENT CARDS

Foreign currency may be brought into the Czech Republic without restrictions. The official currency in the Czech Republic is the Czech crown (Kč). It can be purchased in banks and other exchange offices. The exchange rate is about 32,50 Kč for 1 EUR  (Euro) as of February 2004.

Common international payment cards are usually accepted. Please make inquiries before asking services.

TRANSPORT

The international airport Praha is situated in Ruzyně about 20 km (12 miles) from the city centre and 8 km from the Institute, and is well served by city transport. In addition, airport buses operated by CEDAZ run in about 30-min intervals from the airport to the city terminal (Praha 1, Náměstí Republiky, Metro station of the yellow line B) from 05:30 till 21:30. Airport-bus fare: 90 Kč to city centre, 60 Kč to Dejvická Metro station (as of January 2004).

International trains arrive in Prague at the following railway stations: Praha - hlavní nádraží (Main Station; also a Metro station of the red line C), Praha - Holešovice (Metro station of the red line C), and Praha - Smíchov (Metro station of the yellow line B).

No special transport for the Microsymposium participants from the airport and railway stations is organized.

Public transport

In Prague, an integrated transport system (underground Metro, trams, and buses) operates without conductors. Tickets must be purchased in advance and stamped inside tram or bus, or before passing the gates of the Metro. Ticket machines are in all Metro stations.

In buses, the most common 60-min tickets can be purchased also from the driver, but with an additional charge of 3 Kč and with the exact change only. Tickets for 8 Kč for a single 15-min journey by tram or bus, or four-stop journey by Metro - as well as transfer tickets for 12 Kč for a 60-min (at night, on Saturdays and Sundays 90-min) journey by all means of transport are on sale at the airport, at railway stations, newspaper stands and tobacco shops, at hotel reception desks, in restaurants, etc. The Metro runs from 05:00 till midnight. The timetables are available on Internet: http://www.idos.cz

How to reach the Institute of Macromolecular Chemistry (Praha 6, Petřiny area)

From the Prague Airport, bus No. 179 takes you directly to the Institute (12 stops - "Petřiny" stop).

From the Main Railway Station (Hlavní nádraží), travel by Metro red line C (direction of Ládví) as far as "Vltavská" station (2 stops). From there, take tram No. 1 (direction of Petřiny) to the terminus "Petřiny" (14 stops).

From the Hvězda student dormitory, take any of buses No. 179, 184 or 191 (direction of Petřiny or Letiště Ruzyně) to the "Petřiny" stop (3 stops). You can also walk through Zeyerova Alej along the high-voltage line to the Institute (600 m).

For more details, see http://www.imc.cas.cz/sympo/ginfo/ .

How to reach the Hvězda student dormitory (Praha 6, Petřiny area)

The Hvězda student dormitory is located at the crossing of Ankarská, Zvoníčkova, Brunclíkova and Zeyerova Alej Streets. The nearest bus stop is "Nad Markétou", which is located 50 m from the dormitory (150 m from the reception). The nearest tram stops are "Vypich" (500 m), "Větrník" (700 m), "Obchodní dům Petřiny" (500 m).

From the Prague Airport bus No. 179 takes you directly to the student dormitory (two more stops than to the Institute).

From the Main Railway Station (Hlavní nádraží), travel by Metro red line C (direction of Ládví) as far as "Vltavská" station (2 stops). From there, take tram No. 1 (direction of Petřiny). Get off at the "Větrník" (12th stop) or "Obchodní dům Petřiny" (13th stop) and walk to the dormitory or take a bus No. 179, 184, 191 in the opposite direction to "Nad Markétou" stop (1 stop).

From the Institute, you can either walk through Zeyerova Alej along the high-voltage line to the student dormitory (600 m), or take any of buses No. 179, 184, 191 (direction of Nové Butovice or Na Knížecí) to the "Nad Markétou" stop (2 stops). The student dormitory is the house across the street.

Taxi

Taxis can be hired at the airport or the railway stations. The fare is max. 22 Kč per kilometre and 30 Kč is the boarding fee within the city boundaries (2004 January prices). A special taxi fare from the Prague Airport to the Hvězda student dormitory or the Institute of Macromolecular Chemistry is 500-600 Kč, to downtown 600-700 Kč. The Airport minibus service CEDAZ provides transport to the City for 360 Kč (1-4 persons).

We recommend negotiating the fare before entering a taxi.

REFRESHMENTS AND LUNCHES

Coffee, tea, and soft drinks (included in the registration fee) will be available during the breaks of the programme sessions.

Lunches (included in the registration fee) will be served from Monday to Thursday from 12:30 to 13:30) for active participants and registered accompanying persons (for the latter except for Tuesday) in the refectory of the "Větrník" student dormitory, which is at a walking distance from the Institute (about 1 km, 2 stops by tram). Admission by tickets only.

CORRESPONDENCE

All correspondence should be addressed to the