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Institute of Physiology ASCR, v.v.i.
Videnska 1083
CZ-14220 Prague 4
Czech Republic

Phone:     +420 24106 1111
                  +420 24447 2270
Fax:          +420 24106 2488

E-mail: fgubiomed.cas.cz

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Journal article: Biochimica Et Biophysica Acta-Molecular Cell Research

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

In this study we used scanning mutagenesis of the residues within the putative inner pore S6 region of TRPA1 channel with the aim of understanding the process of TRPA1 activation. We identify residues proline 949, asparagine 954 and glycine–(X)3-glycine motif as structural determinants of TRPA1 activation and deactivation and these findings contribute to our better understanding of molecular mechanisms of pain sensation.

Benedikt J, Samad A, Ettrich R, Teisinger J, Vlachova V.: Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel. Biochimica Et Biophysica Acta-Molecular Cell Research 2009; 1793: 1279-1288. IF=4.893

Author: benediktbiomed.cas.cz
 

 




Journal article: Journal of Structural Biology
A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail.

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Journal article: International Journal of Biochemistry and Cell Biology
Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia.

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Journal article: American Journal of Physiology-Heart and Circulatory Physiology
Pathways to embryonic heart failure.

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Journal article: Neuroscience
Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents.

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Journal article: Epilepsia
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-d-aspartate (NMDA) in immature rats.

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Journal article: Neuroscience
Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

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Journal article: Endocrinology
Chronic Intermittent Hypoxia Induces 11Beta-Hydroxysteroid Dehydrogenase in Rat Heart.

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Journal article: Epilepsia
Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats.

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Journal article: International Journal of Biochemistry and Cell Biology
Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

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Journal article: Chronobiology International
Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint Kinase Wee1 Expression along the Gut.

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Journal article: Journal of Neurophysiology
The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level.

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Journal article: Proceedings of the National Academy of Sciences of the USA
Spatial decisions and cognitive strategies of monkeys and humans based on abstract spatial stimuli in rotation test.

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Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

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Review articles in prestige journal Nature Genetics
Identification of osteoglycin (Ogn) as a genetic determinant predisposing to left ventricular hypertrophy in rats, mice, and humans

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Review articles in prestige journal Nature Genetics
Identification of single nucleotide polymorphisms and haplotype mapping in the rat

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Review articles in prestige journal Nature Genetics
Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

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Journal article: Nature Genetics
Molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

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Article: Obesity
Chemical derivatives of docosahexaenoic acid (DHA) in the prevention and reversal of obesity in mice fed a high-fat diet

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Article: Diabetologia
n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

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Journal article: Proceedings of National Academy of Sciences of the USA
Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

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Journal article: FASEB
In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

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Review article: Oncogene
Current informations about the FOXO subgroup of forkhead transcription factors and mechanism of regulation

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Journal article: PLoS Computational Biology
Efficient coding principle confirmed for the sense of smell

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Journal article: Neurobiology of Aging
Evidence of impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mouse model of Alzheimer´s disease.

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Journal article: American Journal of Physiology Endocrinology and Metabolism
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance

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Journal article: Journal of Pineal Research
The role of proline residues in the structure and function of human MT2 receptor.

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