Zaměstnanci

Jméno Mertlíková-Kaiserová Helena
Pozice Vedoucí týmu

Dr. Helena Mertlíková-Kaiserová

Helena Mertlíková-Kaiserová, Ph.D.

Head of the Team


Biochemical Pharmacology of Antimetabolites
Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Phone: (+420) 220 183 114
Fax: (+420) 220 183 560

 
Education
2003-2007 Ph.D. in Biochemistry, under supervision of Prof. Dr. E. Kvasničková (field: Pathobiochemistry and Xenobiochemistry), Faculty of Pharmacy in Hradec Králové, Charles University in Prague.
1998-2003 M.Sc. in Pharmacy, under supervision of Prof. Dr. E. Kvasničková, Faculty of Pharmacy in Hradec Králové, Charles University in Prague.
 
Experience
2005 Internship at the Department of Pharmacology and Toxicology, University of Maastricht - Prof. Dr. A.Bast.
 
Appointments
since 2010 Head of the "Biochemical Pharmacology of Antimetabolites" research-service team, Institute of Organic Chemistry and Biochemistry, v.v.i., AS CR, Prague.
2009-2010 Scientist at Prof. Dr. A. Holý research team, Institute of Organic Chemistry and Biochemistry v.v.i., AS CR, Prague.
2007-2009 Postdoctoral fellow with Prof. Dr. A. Holý, Institute of Organic Chemistry and Biochemistry v.v.i., AS CR, Prague.
 
Awards and Fellowhisps
2009 Medal of the Faculty of Pharmacy, Charles University (at the occasion of 40th anniversary of the faculty's foundation).
2007 Prize of the Czech Minister of Education for excellent results and creativity during the postgraduate studies in the field of Pathobiochemistry and Xenobiochemistry.
2003 Dean's Prize for the graduate students with excellent results during their studies (Charles University, Faculty of Pharmacy).
2002 Czech Pharmaceutical Society's Prize for best student's research work: lecture "Contribution to the preclinical evaluation of new lipophilic iron chelators" presented at Student's Scientific Conference in Hradec Králové, April 2002.
 
Research interest
Biochemistry and biochemical pharmacology of nucleoside/nucleotide analogs, anticancer drugs, apoptosis, DNA damage, reactive oxygen species.
 
List of papers

Šimůnek T., Štěrba M., Popelová O., Kaiserová H., Adamcová M., Hroch M., Hašková P., Ponka P., Geršl V.:
Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone.
British Journal of Pharmacology 155 (1): 138-48, 2008.

Šimůnek T., Štěrba M., Popelová O., Kaiserová H., Potáčová A., Adamcová M., Mazurová Y., Ponka P., Geršl V.:
Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity.
Hemoglobin 32 (1-2): 207-15, 2008.

Kaiserová H., Šimůnek T., Štěrba M., den Hartog G.J.M., Schröterová L., Popelová O., Geršl V., Kvasničková E., Bast A.:
New iron chelators in anthracycline-induced cardiotoxicity.
Cardiovascular Toxicology 7 (2): 145-50, 2007.

Adamcová M., Šimůnek T., Kaiserová H., Popelová O., Štěrba M., Potáčová A., Vávrová J., Maláková J., Kvasničková E., Geršl V.:
In vitro and in vivo examination of Cardiac troponins as biochemical markers of anthracycline-induced cardiotoxicity.
Toxicology 237 (1-3): 218-28, 2007.

Kaiserová H., Šimůnek T., van der Vijgh W.J.F., Bast A., Kvasničková E.:
Flavonoids as protectants against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductases.
Biophysica Biochimica Acta 1772 (9): 1065-74, 2007.

Štěrba M., Popelová O., Šimůnek T., Mazurová Y., Potáčová A., Adamcová M., Guncova I., Kaiserová H., Palička V., Ponka P., Geršl V.:
Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH).
Toxicology 253 (3): 150-66, 2007.

Bast A., Kaiserová H., den Hartog G.J.M., Haenen G.R.M.M., van der Vijgh W.J.F.:
Protectors against doxorubicin-induced cardiotoxicity: Flavonoids.
Cell Biology and Toxicology 23 (1): 39-47, 2007.

Kaiserová H., den Hartog G.J.M., Šimůnek T., Schröterová L., Kvasničková E., Bast A.:
Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British Journal of Pharmacology 149 (7): 920-930, 2006.

Štěrba M., Popelová O., Šimůnek T., Mazurová Y., Potáčová A., Adamcová M., Kaiserová H., Ponka P., Geršl V.:
Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity.
Journal of Pharmacology and Experimental Therapy 319 (3): 1336-47, 2006.

Kaiserová H., Kvasničková E.:
Inhibition study of rabbit liver cytosolic reductases involved in daunorubicin toxication.
Journal of Enzyme Inhibition and Medicinal Chemistry 20 (5): 477-483, 2005.

Schröterová L., Kaiserová H., Baliharová V., Velík J., Geršl V., Kvasničková E.:
The effect of new lipophilic chelators on activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics. Studies in vitro.
Physiological Research 53 (6): 683-91, 2004.