Research topics
Mapping and functional analysis of genes that control resistance to infection, genetic control of atopy, activation of lymphocytes and cancer susceptibility.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular Ecology of Vectors and Pathogens, grant No.: LC06009)
Grant Agency of the Czech Republic (grant No.: GA310/08/1697)
Most important recent papers
(2005-present; names of the lab members underlined)Lipoldova M, Havelkova H, Badalova J, Demant P. Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Int J Cancer 114(3): 394-9, 2005. (Pubmed) (DOI)
Gusareva ES, Bragina EJ, Deeva EV, Kazakevich NV, Puzyrev VP, Ogorodova LM, Lipoldova M. Cat is a major allergen in patients with asthma from west Siberia, Russia. Allergy 61(4): 509-10, 2006. (Pubmed) (DOI)
Havelkova H, Badalova J, Svobodova M, Vojtikova J, Kurey I, Vladimirov V, Demant P, Lipoldova M. Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun 7(3): 220-33, 2006. (Pubmed) (DOI)
Gusareva ES, Ogorodova LM, Chernyak BA, Lipoldova M. Relationship between total and specific IgE in patients with asthma from Siberia. J Allergy Clin Immunol 121(3): 781; author reply 781, 2008. (Pubmed) (DOI)
Gusareva ES, Havelkova H, Blazkova H, Kosarova M, Kucera P, Kral V, Salyakina D, Muller-Myhsok B, Lipoldova M. Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12. Immunogenetics 61(1): 15-25, 2009. (Pubmed) (DOI)
Gusareva ES, Bragina EJ, Buinova SN, Chernyak BA, Puzyrev VP, Ogorodova LM, Lipoldova M. Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia. Immunol Lett 125(1): 1-6, 2009. (Pubmed) (DOI)
Drahota J, Lipoldova M, Volf P, Rohousova I. Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti. Parasite Immunol 31(12): 766-70, 2009. (Pubmed) (DOI)
Kurey I, Kobets T, Havelkova H, Slapnickova M, Quan L, Trtkova K, Grekov I, Svobodova M, Stassen AP, Hutson A, Demant P, Lipoldova M. Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics 61(9): 619-33, 2009. (Pubmed) (DOI)
Lipoldova M, Havelkova H, Badalova J, Vojtiskova J, Quan L, Krulova M, Sohrabi Y, Stassen AP, Demant P. Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility. Cancer Immunol Immunother. 2009 Aug 5. [Epub ahead of print] (Pubmed) (DOI)
Reviews
Lipoldova M, Demant P. Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat Rev Genet 7(4): 294-305, 2006. (Pubmed) (DOI)
Teaching, lectures, public presentations
Immunity to Infection courses for Czech and English speaking students, Third Faculty of Medicine, Charles University, Prague (presentations)
Český rozhlas Leonardo (interview on Czech Radio)
Popularization - Vesmír