Staff

/ Structure / Technology Transfer / Laboratory of Glycoconjugates / Staff

Name	Ježek Jan
Position	Scientist

Jan Ježek, Ph.D.

Scientist

Laboratory of Glycoconjugates
Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Phone: (+420) 220 183 322
Fax: (+420) 224 310 090


Education
1978-1981	Ph.D. (CSc.) in organic chemistry under supervision of Dr. M.Zaoral at the Institute of Organic Chemistry and Biochemistry, CAS.
1975-1978	M.Sc. (RNDr.) in bioorganic chemistry under supervision of Dr. M.Zaoral at the Charles University and the Institute of Organic Chemistry and Biochemistry, CAS.

Experience
1992-1993	Postdoctoral fellow with Prof. S.Reissmann Institute of Biochemistry and Biophysics, Friedrich-Schiller University, Jena, Germany.
1990	Postdoctoral fellow with Prof. R.A.Houghten, Torrey Pines Institute for Molecular Studies, San Diego, USA.
1989	Postdoctoral fellow with Prof. R.B.Merrifield at the Rockefeller University, New York, USA.
1988	Postdoctoral fellow with acad. V.T.Ivanov at the Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia.

Appointments
since 2004	Senior scientist with the Dr.M. Ledvina at the Institute of Organic Chemistry and Biochemistry, CAS.
1998-2004	Senior scientist with the Dr. J.Velek, at the Institute of Organic Chemistry and Biochemistry, CAS.

Research interest
Peptides and glycopeptides, peptide- and glycopeptide dendrimers, solid phase synthesis, synthetic vaccines, multiple antigen peptides and glycopeptides.

Selected papers
Niederhafner P., Šebestík J., Ježek J.: Glycopeptide dendrimers. Part I. Journal of Peptide Science 14: 2-43 (2008). Niederhafner P., Šebestík J., Ježek J.: Glycopeptide dendrimers. Part II. Journal of Peptide Science 14: 44-65 (2008). Niederhafner P., Reiniš M., Šebestík J., Ježek J.: Glycopeptide dendrimers. Part III – a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases. Journal of Peptide Science 14: 556-587 (2008). Ježek J., El Ridi R., Salah M., Wagih A., Aziz H.W., Tallima H., El Shafie M.H., Khalek T. A., Abo Ammou F.F., Strongylis C., Moussis V., Tsikaris V.: Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis. Biopolymers-Peptide Science 90: 349-357 (2008). Niederhafner P., Gut V., Ježek J., Buděšínský M., Kašička V., Wunsch E., Hlaváček J.: Synthetic study on cystinyl peptides using solution and solid phase methodology: human IgG1 hinge region. Amino Acids in press: (2010). Niederhafner P., Bednárová L., Buděšínský M., Šafařík M., Ehala S., Ježek J., Borovičková L., Fučík V., Čeřovský V., Slaninová J.: Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. Amino Acids in press: (2010).