Research topics
Molecular mechanisms of Wnt signaling in mammalian cells. Signaling pathways influencing behavior of normal and diseased intestinal epithelial cells.
Current Grant Support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular and Cellular Immunology, 1M0506)
Ministry of Education, Youth and Sports of the Czech Republic (NPV II Program, qCHIP/chip06, 2B06077)
Grant Agency of the Czech Republic (grants No's: 204/09/H058, P304/11/1252, P305/11/1780)
Most important recent papers
(2004-present; names of the lab members underlined)Wilson EM, Tureckova J, Rotwein P. Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation. Mol Biol Cell 15(2): 497-505, 2004. (Pubmed) (DOI)
Tureckova J, Vojtechova M, Kucerova D, Velek J, Tuhackova Z. Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase. Int J Mol Med 15(2): 329-35, 2005. (Pubmed)
Tureckova J, Kucerova D, Vojtechova M, Sloncova E, Tuhackova Z. Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. Int J Mol Med 17(1): 69-75, 2006. (Pubmed)
Stokrova J, Sloncova E, Sovova V, Kucerova D, Zila V, Tureckova J, Vojtechova M, Korb J, Tuhackova Z. Characterization of four clones derived from human adenocarcinoma cell line, HT29, and analysis of their response to sodium butyrate. Int J Oncol 28(2): 559-65, 2006. (Pubmed)
Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V. HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J 25(11): 2326-37, 2006. (Pubmed) (DOI)
Asahina M, Valenta T, Silhankova M, Korinek V, Jindra M. Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad. Dev Cell 11(2): 203-11, 2006. (Pubmed) (DOI)
Doubravska L, Simova S, Cermak L, Valenta T, Korinek V, Andera L. Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells. Apoptosis 13(4): 573-87, 2008. (Pubmed) (DOI)
Lukas J, Mazna P, Valenta T, Doubravska L, Pospichalova V, Vojtechova M, Fafilek B, Ivanek R, Plachy J, Novak J, Korinek V. Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Res 37(9): 3007-20, 2009. (Pubmed) (DOI)
Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z. Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol 334(1): 31-45, 2009. (Pubmed) (DOI)
Tureckova J, Vojtechova M, Krausova M, Sloncova E, Korinek V. Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells. Transl Oncol 2(4): 281-90, 2009. (Pubmed)
Klima M, Zajedova J, Doubravska L, Andera L. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793(10): 1579-87, 2009. (Pubmed) (DOI)
Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T, Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cell Signal 23(5): 837-48, 2011. (Pubmed) (DOI)
Pospichalova V, Tureckova J, Fafilek B, Vojtechova M, Krausova M, Lukas J, Sloncova E, Takacova S, Divoky V, Leprince D, Plachy J, Korinek V. Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis 49(3): 142-51, 2011. (Pubmed) (DOI)
Teaching, lectures, public presentations
MB150P89 - Molecular Biology of Cancer - Faculty of Science, Charles University, Prague; semestral course in Czech.