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Technical Assistants:
Ing. Eliška Krejčí
 
PhD students:
MUDr. Jiří Beneš
Mgr. Barbora Šaňková
MUDr. Michal Škácha
Jarmila Svatůňková
MUDr. Radka Kočková
MUDr. Živorad Peševski

 
Department: Cardiovascular Morphogenesis
Head: Doc. MUDr. David Sedmera, PhD.
   
Contact phone/fax number: +429 296442561/+420 296442125
e-mail: dsedmerabiomed.cas.cz
 
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Main Topics:
  1. Determination of factors governing induction and patterning of cardiac conduction system
  2. Developmental mechanisms of arrhythimas
  3. Development of ventricular myocardial architecture
Research topics
  1. Molecular mechanisms of ventricular conduction systém induction (B. Sebestova). This project is testing potential signaling cascades implicated in differentiation of specialized conductive tissues from working cardiomyocytes.

  2. Developmental mechanisms of arrhythimas (J. Benes). In adult cardiology, there is a renewed interest in studying cardiac developments, since numerous pathologies such as heart failure are characterized by re-activation of fetal gene expression program. We are therefore analyzing the rat model of heart failure from this perspective as well as studying the prenatal origin of selected arrhythmias. The above topics are supported by a GACR grant 304/08/0615 entitled "Molecular mechanisms of cardiac conduction system development".

  3. The form of the developing heart is strongly influenced by its function. Over the past decade, it was shown, using several mechanical perturbation models, that hemodynamics is a crucial factor influencing myocardial development. These studies led to formulation of hypothesis stating that structure and function of the developing heart are mutually linked. We now propose to develop these studies further to determine the mechanisms through which the physiological perturbations influence morphogenesis. Using an array of functional, morphological, and molecular techniques, we will analyze established mechanical and novel pharmacological interventions in avian embryonic hearts in vivo and in vitro. The results obtained will broaden our understanding of mechanistic links between structure and function and identify classes of drugs with possible adverse effects on developing cardiovascular system. This topic is currently supported by a GACR grant P302/11/1308 entitled "Epigenetic factors in myocardial morphogenesis".

Publications





Publications 2009
    Damon BJ, Remond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, Thompson RP. 2009. Patterns of muscular strain in the embryonic heart wall. Dev Dyn 238:1535-1546.
    Dealmeida A, Sedmera D. 2009. Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick. Cardiol Young 19:159-169.
    Liska F, Snajdr P, Sedova L, Seda O, Chylikova B, Slamova P, Krejci E, Sedmera D, Grim M, Krenova D, Kren V. 2009. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn 238:673-684.
    Petrovova E, Sedmera D, Lesnik F, Luptakova L. 2009a. Bendiocarb effect on liver and central nervous system in the chick embryo. J Environ Sci Health B 44:383-388.
    Petrovova E, Sedmera D, Misek I, Lesnik F, Luptakova L. 2009b. Bendiocarbamate toxicity in the chick embryo. Folia Biol (Praha) 55:61-65.
    Sedmera D. 2009. Pathways to embryonic heart failure. Am J Physiol Heart Circ Physiol 297:H1578-1579.
Publications 2010
    Sankova B, Machalek J, and Sedmera D. Effects of mechanical loading on early conduction system differentiation in the chick. Am J Physiol Heart Circ Physiol 298: H1571-1576, 2010. Sedmera D. Factors in ventricular and atrioventricular valve growth: An embryologist's perspective. Progress in Pediatric Cardiology 29: 11-14, 2010.
Publications 2011
    Benes J, Jr., Melenovsky V, Skaroupkova P, Pospisilova J, Petrak J, Cervenka L, and Sedmera D. Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload. Anat Rec (Hoboken) 294:102-111, 2011


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