Department of the Molecular Biology of Cancer

Laboratory of the Genetics of Cancer

Research topics

• Investigation of the role of transient markers (DNA and chromosomal damage) in carcinogenesis;
• relationship between transient markers of cancer and individual susceptibility (i. e., relevant candidate genes);
• identification of the mechanisms underlying chromosomal and genomic instability;
• investigation of the role of low-penetrance genes (cell cycle, DNA repair) in the risk of sporadic colorectal cancer and other types of cancer;
• the role of genetic variants in predicting anticancer therapy outcome and overall prognosis;
• investigation of the links between genotype and gene expression with implications for the proper/improper functioning of the cell;
• investigation of somatic mutations in oncogenes and microsatellite status in adenomatous polyposis coli.