Research topics
Focus on in-detail analysis and regulation of signaling triggered by activated "Death Receptors" from the TNFR family mainly in human cancer-derived cells. Characterization of Death Receptor signaling in embryonic and cancer stem cells. Elucidation of an effect of tumor microenvironment on TRAIL-induced apoptosis/signaling in cancer cells. Deciphering role of the adapter protein Daxx in the transcriptional regulation of apoptosis.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular and Cellular Immunology, 1M0506)
GA AS CR (Nanomed - KAN200520703, KJB500520801)
GA CR (P301/10/1971)
IGA Ministry of Health (NS10287-3/2009, co-holder)
Most important recent papers
(2006-present; names of the lab members underlined)Tomasetti M, Andera L, Alleva R, Borghi B, Neuzil J, Procopio A. Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis. FEBS Lett 580(8): 1925-31, 2006. (Pubmed) (DOI)
Oikonomou E, Kothonidis K, Taoufik E, Probert E, Zografos G, Nasioulas G, Andera L, Pintzas A. Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. Br J Cancer 97(1): 73-84, 2007. (Pubmed) (DOI)
Simova S, Klima M, Cermak L, Sourkova V, Andera L. Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis 13(3): 423-36, 2008. (Pubmed) (DOI)
Doubravska L, Simova S, Cermak L, Valenta T, Korinek V, Andera L. Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells. Apoptosis 13(4): 573-87, 2008. (Pubmed) (DOI)
Khunkaewla P, Schiller HB, Paster W, Leksa V, Cermak L, Andera L, Horejsi V, Stockinger H. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Mol Immunol 45(6): 1703-11, 2008. (Pubmed) (DOI)
Klima M, Zajedova J, Doubravska L, Andera L. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793(10): 1579-87, 2009. (Pubmed) (DOI)
Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, Andera L, Zografos G, Pintzas A. TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors. Int J Cancer 125(9): 2127-35, 2009. (Pubmed) (DOI)
Klima M, Brouckova A, Koc M, Andera L. T-cell activation triggers death receptor-6 expression in a NF-kappaB and NF-AT dependent manner. Mol Immunol 48(12-13): 1439-47, 2011. (Pubmed) (DOI)
Reviews
Neuzil J, Stantic M, Zobalova R, Chladova J, Wang X, Prochazka L, Dong L, Andera L, Ralph SJ. Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name? Biochem Biophys Res Commun 355(4): 855-9, 2007. (Pubmed) (DOI)
Andera L. Signaling activated by the death receptors of the TNFR family. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 153(3): 173-80, 2009. (Pubmed)
Zivny J, Klener P Jr, Pytlik R, Andera L. The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies. Curr Pharm Des 16(1): 11-33, 2010. (Pubmed)
Teaching, lectures, public presentations
MB150P79 - Molecular Mechanisms of Apoptosis - Faculty of Science, Charles University, Prague; presentations for Czech students.