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Education |
1979-1983 | Ph.D., Biochemistry, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague. |
1969-1974 | M.Sc., Chemistry, Institute of Chemical Technology, Prague. |
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Experience |
1990-1992 | Postdoctoral research associate, Department of Physiology, University of Florida, U.S.A., Prof. M. K. Raizada. |
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Appointments |
since 2007 | Scientist, Jiracek's group, Institute of Organic Chemistry and Biochemistry v.v.i., Academy of Sciences of the Czech Republic, Prague. |
1985-2006 | Scientist, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague. |
1974-1978 | Research Assistant, Institute of Chemical Technology, Prague. |
1978-9, 1983-5, 1986-9 | Maternity leave. |
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Research interest |
- Structure-activity studies of peptides (cholecystokinin analogues, CART peptides) with special emphasis on their anorectic activity after central and peripheral administration; binding affinities, in vitro and in vivo functional assays.
- Study of food intake regulation in mouse models of obesity.
- Ligand binding and signal transduction in cultured cells (study of LDL receptor, putative CART receptor in neuronal cell cultures).
- Effect of leptin and ghrelin on development of experimental arthritis.Ligand binding and signal transduction in cultured cells (study of LDL receptor, putative CART receptor in neuronal cell cultures).
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