Projects
Our own research is oriented towards studies of molecular conformation, assignment of absolute configuration and investigation of molecular dynamics.
We concentrate on the studies of
- interaction of disulfide groups in proteins and peptides
- modeling of peptides interacting with model membranes
- protein folding
- interaction of ligands with biomolecules
Current projects
- Interaction of antibacterial peptides with model membranes and possibility of the prediction of their biological activity (GA ČR 2010-2012) in collaboration with IFCHE Praha and Institute of Physics, MFF, Charles university in Prague.
- Interactions of disulfide groups in peptide/protein molecules - complementary use of electronic and vibrational optical activity (GA ČR 2010-2012) in collaboration with Institute of Physics, MFF, Charles university in Prague.
Colaboration with the IOCB teams
- Optical activity of helicene and heterohelicene systems and their bioaplication
- Production and characterization of active recombinant human ameloblastin
- Molecular mechanisms of autocatalytic RTX protein FrpC from Neisseria meningitidis
- Study of chemical structure of yeast Candida albicans