Introduction
Novel types of modified derivatives and analogues of nucleobases, nucleosides, nucleotides and nucleic acids are designed and prepared for applications in all areas of biomedicinal sciences (medicinal chemistry, biochemistry, chemical biology, bioanalysis etc.).
Basic developments of methodology for the synthesis of these modified biomolecules are performed largely using modern methods (including metal- or enzyme-catalyzed reactions). Biological activity (cytostatic, antiviral etc.) of the novel nucleobases, nucleosides and nucleotides is systematically studied in collaboration with several groups both in academia and in pharmaceutical industry. Several collaborative projects also address chemical biology of nucleic acids (i.e. DNA polymerase specificity and fidelity). Functionalized nucleic acids bearing diverse interesting and useful substituents are another goal of our group. For details, see Projects.
Hot Papers | News |
Hocek, M. et al: "Nucleobase modification as redox DNA labelling for electrochemical detection" Chem. Soc. Rev. 2011, 40, 5802–5814. Kielkowski, P. et al: "Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727 –8730. Štefko, M. et al: "General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups" J. Org. Chem. 2011, 76, 6619–6635. |
29.9.2011 New member of our group - Anna Tokarenko 14.9.2011 New member of our group - Zuzana Vaníková 5.9.2011 New web pages of our group 1.9.2011 Joint Laoratory of IOCB and Charles University has been officially opened |