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| Education |
| 1987-1991 |
Ph.D. in biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague. |
| 1981-1986 |
M.Sc. in biochemistry, Charles University, Prague, Czech Republic. |
| |
| Experience |
| 1996-1998 (18 months) |
Oklahoma Medical Research Foundation, Oklahoma City, USA. |
| 1994 (2 months) |
Laboratory of Molecular Biophysics, Oxford University, UK. |
| 1992 (3 months) |
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. |
| 1991-1995 (8 months) |
Münster University, Germany. |
| |
| Appointments |
| since 2007 |
Head of the IOCB Research Team (Cathepsin Proteases in Pathology). |
| 2003-2006 |
Head of the Laboratory of Regulation of Proteolysis at IOCB. |
| 2001-2006 |
Postdoctoral Fellow, Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic. |
| since 1991 |
Researcher, Institute of Organic Chemistry and Biochemistry (IOCB), Academy of Sciences of the Czech Republic, Prague. |
| |
| Research interest |
|
Proteases and their regulation in pathological processes, cathepsin proteases in cancer, digestive proteolysis in blood-feeding parasites, allergenic proteases, plant protease inhibitors as insecticides.
Proteomics, protein 3D structures and structure-activity relationship, rational and combinatorial design of small bioactive molecules as chemotherapeutic agents.
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