Hocek Research Team

Ing. Hana Macíčková Cahová, Ph.D.

e-mail: cahova@uochb.cas.cz
phone: +420 220183399

Born 27. 12. 1981 in Zlín (Czech Republic).

Scientific CV:
2001-2006 undergraduate study, Prague Institute of Chemical Technology, M. S. degree - specialization organic chemistry (supervisor Associate Prof. I. Linhart)
2005 study abroad for 4 months ENSCM, Montpellier, France (group of prof. J. Moreau, supervisor P. Hesemann)
2006-2010 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2010 Postdoctoral stay, University of Heidelberg, Jäschke's Group

List of publications:

11.	Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: "Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727 –8730.
10.	Macíčková-Cahová, H.; Pohl, R.; Horáková, P.; Havran, L.; Špaček, J.; Fojta, M.; Hocek, M.: "Alkylsulfanylphenyl Derivatives of Cytosine and 7-Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study" Chem. Eur. J. 2011, 17, 5833–5841.
9.	Horáková, P.; Macíčková-Cahová, H.; Pivoňková, H.; Špaček, J.; Havran, L.; Hocek, M.; Fojta, M.: "Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl tranferase. Application in electrochemical DNA hybridization and protein-DNA binding assays" Org. Biomol. Chem. 2011, 9, 1366 – 1371.
8.	Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: "Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases" ChemBioChem 2011, 12, 431 – 438.
7.	Macíčková-Cahová, H.; Vrábel, M.; Hocek, M.: "Cross-Coupling Modification of Nucleoside Triphosphates, PEX, and PCR Construction of Base-Modified DNA" Curr. Protoc. Chem Biol. 2010, 2, 1-14.
6.	Ikonen, S.; Macíčková-Cahová, H.; Pohl, R.; Šanda, M.; Hocek, M.: "Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA" Org. Biomol. Chem. 2010, 8, 1194-1201.
5.	Macíčková-Cahová, H.; Hocek, M.: "Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases" Nucleic Acids Res. 2009, 37, 7612–7622.
4.	Vrábel, M.; Horáková, P.; Pivoňková, H.; Kalachova, L.; Černocká, H.; Cahová, H.; Pohl, R.; Šebest, P.; Havran, L.; Hocek, M.; Fojta, M.: "Base-Modified DNA Labeled by [Ru(bpy)₃]²⁺ and [Os(bpy)₃]²⁺ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications" Chem. Eur. J. 2009, 15, 1144-1154.
3.	Cahová, H.; Pohl, R.; Bednárová, L.; Nováková, K.; Cvačka, J.; Hocek, M.: "Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA" Org. Biomol. Chem. 2008, 6, 3657-3660.
2.	Cahová, H.; Havran, L.; Brázdilová, P.; Pivoňková, H.; Pohl, R.; Fojta, M.; Hocek, M.: "Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection" Angew. Chem. Int. Ed. 2008, 47, 2059–2062.
1.	Čapek, P.; Cahová, H.; Pohl, R.; Hocek, M.; Gloeckner, C.; Marx, A.: "An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross-Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR" Chem. Eur. J. 2007, 13, 6196–6203.