Hosek Research Team
Hosek Research Team
Hocek Research Team

Ing. Peter Šilhár, Ph.D.

Ing. Peter Šilhár, Ph.D.

e-mail: silhar@uochb.cas.cz



Born 31. 3. 1980 in Bratislava (Slovak Republic).

Scientific CV:
1998-2003 undergraduate study, Slovak University of Technology in Bratislava, M. S. degree - specialization organic chemistry (supervisor Ing. Jedlovská)
2003-2007 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2007 Postdoctoral stay, Bern University, Leumann Group

Participation on projects: Synthesis of purine derivatives bearing highly functionalized C-substituents


List of publications:
11. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
10. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide – Scope and Limitations of the Reaction" Synlett 2008, 543–546.
9. Hasník, Z.; Šilhár, P.; Hocek, M.: "Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent" Tetrahedron Lett. 2007, 48, 5589–5592.
8. Hocek, M.; Šilhár, P.: "Palladium-Catalyzed Cross-Coupling Reactions in C6 Modifications of Purine Nucleosides" Curr. Protocols Nucleic Acid Chem. (J. Wiley & Sons., Inc.) 2007, 1.16.
7. Hocek, M.; Šilhár, P.; Pohl, R.: "Cytostatic and activiral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3'-deoxyribonucletides" Collect. Czech. Chem. Commun. 2006, 71, 1484-1496.
6. Hocek, M.; Šilhár, P.; Shih, I.; Mabery, E.; Mackman, R.: "Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine L-ribonucleosides" Bioorg. Med. Chem. Lett. 2006, 16, 5290–5293.
5. Šilhár, P.; Pohl, R.; Votruba, I.; Klepetářová, B.; Hocek, M.: "Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl- 2-(Hydroxymethyl)purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2006, 71, 788-803.
4. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis and Cytostatic Activity of Novel 6-(Difluoromethyl)purine Bases and Nucleosides" Synthesis 2006, 1848-1852.
3. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of 2-Substituted 6-(Hydroxymethyl)Purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2005, 70, 1669-1695.
2. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "The First Synthesis and Cytostatic Activity of Novel 6-(Fluoromethyl)purine Bases and Nucleosides" Org. Biomol. Chem. 2005, 3, 3001-3007.
1. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Facile and Efficient Synthesis of 6-(Hydroxymethyl)purines" Org. Lett. 2004, 6, 3225-3228.
© Michal Hocek
Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic
Design by WeBratři.cz