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| Education |
| 1952-1956 |
Charles' University, Prague (Biology). |
| |
| Appointments |
| since 2007 |
Institute of Organic Chemistry and Biochemistry, Prague. |
| 1993-2006 |
Institute of Molecular Genetics, Prague. |
| 1956-1992
| Institute of Virology, Bratislava. |
| |
| Experience |
| 1965 |
Institute of Virology, Glasgow. |
| 1969, 1975
| ICRF, London. |
| 1982 |
Harvard Medical School, Boston. |
| |
| Teaching |
| 1960-1969 |
Comenius' University, Bratislava (General Virology). |
| since 1993 |
Charles' University, Prague (Molecular and Cellular Oncology). |
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| Research interest |
|
Phenotypic mixing(pseudotypes) of mutually unrelated viruses, mostly of vesicular stomatitis virus (VSV) with envelope proteins of retroviruses.
Phenotypic mixing turned out to be universal among all envelopedviruses, suggesting a common mechanism of assembly of surface viral proteins.
Somewhat surprisingly, VSV acquires into its envelope also certain cellular proteins, which however mimic viral surface glycoproteins. This enabled us to discover
a novel protein - carbonic anhydrase IX (CAIX). It is a transmembrane protein, which like viral gps forms trimers and can attach to cell surface receptors. CAIX is associated with many human carcinomas, it
could possibly serve as a tumor marker or as a molecular target for therapy.
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