AB SCIEX TripleTOF™ 5600 with Dionex ULTIMATE 3000 HPLC system

The AB SCIEX TripleTOF 5600 is the next generation in Quadrupole TOF technology. Starting with the best-in-class Triple Quad 5500 System, the new AcceleratorTOF Analyzer was developed to add high-resolution at the speed and sensitivity needed to give equivalent CV's and limits of quantitation (LOQ) to high-end triple quadrupoles. The mass spectrometers uniquely integrates comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines the highest sensitivity detection, high-resolution with 100 Hz acquisition speed, and stable ~1 ppm mass accuracy over days of acquisition. The spectrometer is connected with Dionex ULTIMATE 3000 HPLC system. The instrument was installed in summer 2011.

LTQ Orbitrap XL

LTQ Orbitrap XL (Thermo Fisher Scientific) is a hybrid FT mass spectrometer combines a linear ion trap MS and the Orbitrap mass analyzer. Ions generated by API (APCI, ESI, nanoESI) are collected in the LTQ XL followed by axial ejection to the C-shaped storage trap which is used to store and collisionally cool ions before injection into the orbitral trap. The ions transferred from the C-Trap are captured in the orbitral trap by rapidly increasing the electric field and the detection of the image current from coherent ion packets takes place after the voltages have stabilized. Signals from each of the orbitral trap outer electrodes are amplified and transformed into a frequency spectrum by fast Fourier transformation which is finally converted into a mass spectrum. Dynamic range up tu 2000 u, excelent mass accuracy (better then 5 ppm), fast cycle times for MS/MS experiments and high sensitivity are features of this instrument. LTQ Orbitrap XL can be coupled to UHPLC system for LC/MS applications. This instrument was installed in January 2008.

LCQ Fleet

LCQ Fleet (Thermo Fisher Scientific) is a 3D ion trap mass spectrometer capable of multiple stage (MSⁿ) analyses. The instrument has an atmospheric pressure ionization source that supports ESI and APCI probes. The optimal mass range of the spectra is 50 - 2000 Da. LCQ Fleet can be coupled to HPLC system for LC/MS applications. Applications include clinical and forensic toxicology, natural product analysis, impurity analysis, metabolite profiling and general analytical chemistry. This instrument was installed in February 2008.

Q-Tof micro

Q-Tof micro (Waters) is a quadrupole orthogonal acceleration time-of-flight tandem mass spectrometer that enables exact mass measurement in both MS and MS/MS modes of analysis. ESI, nano-ESI and APCI ion sources are available. Q-Tof micro is coupled to CapLC capillary HPLC for tryptic digest separations. The instrument was installed in 2004.

ultrafleXtreme™

UltrafleXtreme™MALDI-TOF/TOF mass spectrometer (Bruker Daltonics, Germany) is the only instrument combining true 1 kHz smartbeam II laser technology speed in both TOF and TOF/TOF modes with ultra-high performance and extreme flexibility. The instrument was installed in 2011.