Moravcová, Daniela; Kryštof, Vladimír; Havlíček, Libor; Moravec, Jiří; Lenobel, René; Strnad, Miroslav
BIOORGANIC AND MEDICAL CHEMISTRY LETTERS
13 [18]:
2989-2992,
2003
Keywords:
Pyrazolo[4,3-d]pyrimidines; CDK1/cyclin B; anticancer agents
Abstract:
A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
IEB authors: Libor Havlíček,
René Lenobel,
Miroslav Strnad
Čeština
English