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Grant projects implemented at IMG in 2012

    2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012

GRANT AGENCY GRANT´S NUMBER THE GRANT´S NAME GRANT´S
CO-ORDINATOR
GROUP
GSF GAP301/10/2174 Epigenetic mechanisms in regulativ of genes important for antigen presentation and antitumour immunity M. Reiniš 11
GSF GPP301/11/P220 Mechanisms underlying cyclophosphamide-induced accumulation of myeloid derived suppressor
cells
R. Mikyšková 11
GSF GAP304/12/1736 Development of CpG methylation of HIV-1 promoter and its stabilizing effect on the latent provirus reservoir: Longitudinal study in patients K. Trejbalová 12
GSF GAP502/10/1651 Characterization of new avian sarcoma and leukosis virus (ASLV) receptor alleles as revealed by the analysis of semiresistant cells J. Plachý 12
GSF GAP502/11/2207 Avian Sarcoma and Leukosis Virus-based Vectors and Their Potential for Transgenesis in chicken J. Hejnar 12
GSF GA310/09/2084 Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts D. Filipp 13
GSF GAP303/12/2408 Functional consequences of metabotropic glutamate receptor 1a and 1b splice variants assembly in heterodimeric complexes J. Blahoš 14
GSF GA303/08/1591 Study of glutamate receptors conformational changes using novel fluorescent techniques J. Blahoš 14
GSF GA310/08/1697 First genetic model for analysis of susceptibility to parasite Leishmania tropica: potential implications for studies of human leishmaniases M. Lipoldová 15
GSF GAP502/11/2116 Differences in clinical course of tick-borne encephalitis in host, and their genetic determination M. Lipoldová (co-investigator) 15
ASCR KAN200520801 Targeted expression and transport of bioactive molecules D. Staněk 16
GSF GAP305/10/0424 Regulation of alternative splicing via chromatin acetylation D. Staněk 16
GSF GAP302/11/1910 Formation of splicing machinery in the context of the cell nucleus D. Staněk 16
GSF P305/12/G034 Centre for RNA biology D. Staněk (co-investigator) 16
GSF GPP301/12/P425 Functional analysis of hBrr2 mutations linked to retinitis pigmentosa Z. Cvačková 16
GA ASCR IAA500520812 Investigating the pathologic role of metalloproteinases in liver using transgenic mice with conditional expression of transgenes R. Sedláček 18
GSF GAP305/10/2143 Generation of mouse models for targeting stelete cells and myofibroblasts in the liver R. Sedláček 18
GSF GAP303/10/2044 The Impact of a liver-specific deficiency of growth factor sheddase ADAM10 on liver development and pathology R. Sedláček 18
GSF GAP302/11/2048 Function of metalloproteinases in colon epithelium and during development of experimental colitis and colon cancer R. Sedláček 18
OPVK CZ.1.07/2.3.00/20.0102 Founding of an expert team for the Centre for Phenogenomics R. Sedláček 18
OPVK CZ.1.07/2.3.00/30.0027 Establishment of the Centre of Transgenic Technologies R. Sedláček 18
ASCR KAN200520804 Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances

V. Holáň

19
GSF GA206/08/0640 Host-parasite relationship, hybrid zone, immune systém, house mouse, Mus musculus V. Holáň (co-investigator) 19
GSF GAP304/11/0653 Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models V. Holáň 19
GSF GAP301/11/1568 Cellular aspects of transplantation tolerance V. Holáň (co-investigator) 19
GSF GAP305/11/1780 Wnt signaling in self-renewal and tumorigenesis of the intestinal epithelia V. Kořínek 20
GSF GAP304/11/1252 Bacteria in etiology, prevention ant therapy of experimentally induced intestinal inflammation and colon cancer V. Kořínek (co-investigator) 20
GSF GAP305/12/2347 Molecular mechanisms of the tumor suppressor function of the HIC1 gene V. Kořínek 20

ASCR

Premium Academiae Premium Academiae J. Forejt 21
GSF GAP305/10/1931 Identification of interactors of the meiotic histone methyltransferase Hybrid sterility 1 /PR-domain 9) Z. Trachtulec 21
MH CR LD11079 (program COST CZ) New mouse models for the study of biomedical complex traits and human diseases and for systemic genetics J. Forejt 21
GSF GPP305/11/P630 Epigenetic regulators of gene expression in mouse spermatogenesis O. Mihola 21
ASCR M200520901 Novel components of mast cell immune receptor signalling Pe. Dráber 22
GSF GA301/09/1826 Topography and function of Csk-binding proteins of the plasma membrane in mast cells  Pe. Dráber 22
TA CR TA01010436 New generations of DNA aptamers Pe. Dráber 22
GSF GAP302/10/1759 Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells L. Dráberová 22
MIT FR-TI3/067 Genetically modified polymerases and their utilization for amplification of non-purified DNA Pe. Dráber 22
GSF GAP301/10/1971 Expression, signaling and function of Death Receptors in human embryonic stem cells L. Anděra 23
GSF GEMEM/09/E011 Signaling and adaptor proteins of leukocyte membrane microdomains V. Hořejší 24
GSF GAP305/11/0459 The effect of transmembrane domains of integral proteins on dynamic organisation of the plasma membrane of T lymphocytes T. Brdička (co-investigator) 24
GSF P302/12/G101 Molecular mechanisms of signaling through leukocyte receptors their role in health and disease. V. Hořejší 24
GSF GAP302/12/1712 Function of Csk-anchoring proteins SCIMPand PSTPIP2 in leukocyte signaling and inflammation T. Brdička 24
GSF GD204/09/H084 Molecular biology of a  differentiating cell P. Hozák 25
GSF GAP305/11/2232 Functions of myosin I and its binding partners in the cell nucleus P. Hozák 25
MIT FR-TI3/588 Development of a kit for detection of mutations in structural proteins of a cell P. Hozák 25
GSF GAP302/12/1673 Role of gamma-tubulin complexes in regulation of cell cycle progression Pa. Dráber 26
GSF GAP302/10/1701 Analysis of functional differences between gamma-tubulins E. Dráberová 26
GSF GPP302/11/P709 Analysis of microtubular changes during activation of mast cells V. Sulimenko 26
GSF GA204/09/0085 RNA silencing and long dsRNA in mammalian cells P. Svoboda 28
GSF GAP305/10/2215 Control of chromatin and pluripotency by microRNAs P. Svoboda 28
ME CR ME09039 Role of posttranslational mechanisms in reprogramming mouse oocytes to pluripotent cells P. Svoboda 28
GA ASCR IAA500520908 The role of Pax genes in eye evolution Z. Kozmik 29
GSF GD204/09/H058 Intercellular signalling in development of the organism and in disease genesis Z. Kozmik (co-investigator) 29
GSF GAP301/11/2198 Genetics of mammalian eye development Z. Kozmik 29
GSF GAP305/10/2141 Evolution of photoreceptors: insights from ancestral regulatory circuits Z. Kozmik 29
GSF - Eurocores GCP305/10/J064 Reconstructing urbilaterian photoreceptors: comparative study between Branchiostoma (Chordata) and Platynereis (Annelida) Z. Kozmik (co-investigator) 29
GSF GAP305/12/2042 The role of transcription factors Tcf in the induced cell pluripotency (iPS) and during neurogenesis O. Machoň 29
GSF GA203/09/0820 Structurally inspired synthese of the selectiv inhibitors nukleotidas, potentially important medicals J. Brynda 31
GSF GCP305/10/J052 Functional analysis of endogenous retroviral elements in human genome: possible association with cancers J. Pačes 33
GSF GAP305/11/1061 Evoluce parazitismu: analýza genomu a klíčových fyziologických funkcí volně žijící améby Mastigamoeba balamuthi a patogena Entamoeba histolytica J. Pačes (co-investigator) 33
GSF GAP506/11/1317 Diverzita a evoluce anaerobních  heteroloboseí Č. Vlček (co-investigator) 33
GSF GAP506/11/1320 Establishment of the secondary plastid in euglenids Č. Vlček (co-investigator) 33
GSF GAP506/12/1010 Oxymonad and trimastix genome sequencing V. Pačes (co-investigator) 33
GSF GAP304/12/1333 Intercelllular interactions in malignant melanoma - experimental study H. Strnad (co-investigator) 33
GSF GA203/09/1311 Synthetic probes for recognition of tumor markers: applications for cell directed
apoptosis and targeted photodynamic therapy
J. Králová 36
GSF GA301/09/1727 Large-scale identification of genes responsible for the formation of solid tumours M. Dvořák 36
GSF GAP305/10/2133 The study of satellite cells migration P. Kašpar 36
GSF GAP303/11/1291 New types of ligands interfering with cancer cell communication as a new therapeutic strategy J. Králová (co-investigator) 36
GSF GA204/08/1418 The role of the JAK/STATsignalling pathway in cellular senescence

Z. Hodný

37
GSF GPP305/10/P420 Role of Wip1 phosphatase in the DNA damage response L. Macůrek 37
GSF GAP301/10/1525 Mechanisms of DNA damage checkpoint termination J. Bartek 37
GSF GPP305/11/P683 Post-translational modifications of Daxx and their functional relevance in DNA
damage response and cellular senescence
H. Hanzlíková 37
GSF GAP305/12/2485 Structure and function of proteins involved in DNA damage signaling L. Macůrek 37
GSF GA310/08/0878 The role of the cells prion protein in erytroidnic differentiation P. Bartůněk (co-investigator) 38
GSF GA204/09/1905 Disp3: A potential role in the self renewal and differentiation of neural stem cells P. Bartůněk 38
GSF GAP305/10/0953 New regulators of megakaryocyte and erythroid lineage commitment P. Bartůněk 38
GSF GAP301/12/1478 The role of DISP3 protein in lipid metabolism P. Bartůněk 38
OPPK

CZ-OPENSCREEN

CZ.2.16/3.1.00/24020
Národní infrastruktura pro chemickou biologii P. Bartůněk 38
GSF GA204/09/0565 Role of  RECQ5 DNA helicase in maintenance of genomic stability P. Janščák 42
GSF GAP305/10/0281 Role of the Rothmund-Thomson syndrome gene product in maintenance of genomic
stability
P. Janščák 42
GSF GAP302/11/1481 Serine proteases of human parasite Schistosoma mansoni and their function in host-parasite interactions J. Dvořák 43
EU FP7 PIRG05-GA-2009-248642 Schistosoma Protease J. Dvořák 43
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