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Institute of Physiology ASCR, v.v.i.
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E-mail: fgubiomed.cas.cz

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Journal article: Neuroscience

Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. In this work the effect of insulin application on fast excitatory postsynaptic currents (EPSCs) mediated by AMPA receptors evoked in DH neurons was evaluated. Acute spinal cord slices from 6 to 10 day old mice were used to record EPSCs evoked in visually identified superficial DH neurons by dorsal root primary afferent stimulation. AMPA EPSCs could be evoked in all of the tested neurons. In 75% of the neurons the size of the AMPA EPSCs was reduced to 62.1% and to 68.9% of the control values when 0.5 or 10 _M insulin was applied.Our results suggest a possible role of the insulin pathway in modulation of sensory and nociceptive synaptic transmission in the spinal cord.

Špicarová D., Paleček J.: Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin. Neuroscience 2010; 166: 305-311. IF=3.556

Author: dianaspicarovabiomed.cas.cz
 




Journal article: PLoS ONE
Variability Measures of Positive Random Variables.

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Journal article: Neuroscience
Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light.

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Journal article: Neuroscience
Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices.

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Journal article: Proceedings of the National Academy of Sciences of the USA
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object.

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Journal article: Biochimica et Biophysica Acta
Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.

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Journal article: American Journal of Physiology
Circadian regulation of electrolyte absorption in the rat colon

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Journal article: Journal of Neuroinflammation
Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy.

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Journal article: Current Pharmaceutical Biotechnology
A "cute" desensitization of TRPV1

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Journal article: Behavioural Brain Research
Inertial stimuli generated by arena rotation are important for acquisition of the active place avoidance task.

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Journal article: Chronobiology International
Hepatic, Duodenal, and Colonic Circadian Clocks Differ in their Persistence under Conditions of Constant Light and in their Entrainment by Restricted Feeding.

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Journal article: Amino Acids
Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails.

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Journal article: Mitochondrion
Evaluation of basic mitochondrial functions using rat tissue homogenates.

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Review article: Cardiovascular Research
Function and form in the developing cardiovascular system.

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Journal article: Journal of Hypertension
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin

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Journal article: Journal of Comparative Neurology
Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats.

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Journal article: Epilepsia
Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

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Journal article: Analytical and Bioanalytical Chemistry
Determination of insoluble avian eggshell matrix proteins.

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Journal article: Journal of Biological Rhythms
Exposure of Pregnant Rats to Restricted Feeding Schedule Synchronizes the SCN Clocks of Their Fetuses under Constant Light but Not under a Light-Dark Regime

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Journal article: Journal of Neuroinflammation
Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine

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Journal article: Journal of Chromatography A
Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by high-performance liquid chromatography-mass spectrometry and capillary zone electrophoresis-mass spectrometry.

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Journal article: Biochimica Et Biophysica Acta-Bioenergetics
Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c.

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Journal article: Journal of Biological Chemistry
Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels.

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Journal article: Journal of Bioenergetics and Biomembranes
Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase.

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Journal article: Biochimica Et Biophysica Acta-Molecular Cell Research
Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

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Journal article: Journal of Structural Biology
A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail.

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Journal article: International Journal of Biochemistry and Cell Biology
Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia.

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Journal article: American Journal of Physiology-Heart and Circulatory Physiology
Pathways to embryonic heart failure.

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Journal article: Neuroscience
Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents.

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Journal article: Epilepsia
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-d-aspartate (NMDA) in immature rats.

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Journal article: Endocrinology
Chronic Intermittent Hypoxia Induces 11Beta-Hydroxysteroid Dehydrogenase in Rat Heart.

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Journal article: Epilepsia
Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats.

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Journal article: International Journal of Biochemistry and Cell Biology
Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

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Journal article: Chronobiology International
Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint Kinase Wee1 Expression along the Gut.

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Journal article: Journal of Neurophysiology
The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level.

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Journal article: Proceedings of the National Academy of Sciences of the USA
Spatial decisions and cognitive strategies of monkeys and humans based on abstract spatial stimuli in rotation test.

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Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

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Review articles in prestige journal Nature Genetics
Identification of osteoglycin (Ogn) as a genetic determinant predisposing to left ventricular hypertrophy in rats, mice, and humans

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Review articles in prestige journal Nature Genetics
Identification of single nucleotide polymorphisms and haplotype mapping in the rat

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Review articles in prestige journal Nature Genetics
Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

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Journal article: Nature Genetics
Molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

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Article: Obesity
Chemical derivatives of docosahexaenoic acid (DHA) in the prevention and reversal of obesity in mice fed a high-fat diet

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Article: Diabetologia
n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

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Journal article: Proceedings of National Academy of Sciences of the USA
Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

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Journal article: FASEB
In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

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Review article: Oncogene
Current informations about the FOXO subgroup of forkhead transcription factors and mechanism of regulation

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Journal article: PLoS Computational Biology
Efficient coding principle confirmed for the sense of smell

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Journal article: Neurobiology of Aging
Evidence of impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mouse model of Alzheimer´s disease.

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Journal article: American Journal of Physiology Endocrinology and Metabolism
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance

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Journal article: Journal of Pineal Research
The role of proline residues in the structure and function of human MT2 receptor.

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