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| Education | 
 
| 1964-1969 | Ph.D. (CSc.) in biochemistry, under supervision of Dr. Dezider Grunberger at the Institute of Organic Chemistry and Biochemistry, 
Czechoslovak Academy of Sciences, Prague. | 
        
| 1971 | RNDr. degree in biochemistry, Department of Biochemistry, Faculty of Natural Sciences, Charles University, Prague. | 
 
| 1959-1964 | M.Sc. in biochemistry, under supervision of Prof. Josef Koštír at the Department of Biochemistry, Faculty of Natural Sciences,
 Charles University, Prague. | 
 
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| Scholarship | 
 
  
| 1987 | Visiting Scientist at Prof. R. T. Borchardt, Department of Pharmaceutical Chemistry, University of Kansas.
1986 Visiting Scientist at Prof. E. De Clercq, Rega Institute, Leuven, Belgium. | 
 
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| Appointments | 
 
| 1990-2006 | Vice-Head of the Department of chemistry and biochemistry of nucleosides and nucleotides analogues, Institute of Organic Chemistry 
and Biochemistry v.v.i., Academy of Sciences of the Czech Republic, Prague. | 
 
| since 2001 | Doctor of Science. | 
 
| 1983-2006 | Head of the Group of Biochemistry, Department of Chemistry and biochemistry of nucleosides and nucleotides analogues. | 
 
 
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| Awards and Fellowhisps | 
 
| 1986 | National Prize for Science and Technique. | 
 
 
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| Research interest | 
 
| Biochemistry of nucleic acids, antimetabolites and enzymology; mode of action of chiral acyclic nucleoside and 
nucleotide analogues possessing antiviral and cytostatic activities. |