Hocek Research Team

2013
149.	Kalachová, L.; Pohl, R.; Bednárová, L.; Fanfrlík, J.; Hocek, M.: "Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations" Org. Biomol. Chem. 2013, 11, 78-89.
2012
148.	Riedl, J.; Ménová, P.; Pohl, R.; Orság, P.; Fojta, M.; Hocek, M.: "GFP-like Fluorophores as DNA Labels for Studying DNA-Protein Interactions" J. Org. Chem. 2012, 77, 8287-8293.
147.	Tichý, M.; Pohl, R.; Xu, H. Y.; Chen, Y.-L.; Yokokawa, F.; Shi, P.-Y.; Hocek, M.: "Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides" Bioorg. Med. Chem. 2012, 20, 6123–6133.
146.	Kubelka, T.; Slavětínská, L.; Hocek, M.: "Synthesis of Substituted Benzyl Homo-C-ribonucleosides and -nucleotides as Carba Analogues of Phosphoribosylanthranilate" Eur. J. Org. Chem. 2012, 4969–4981.
145.	Riedl, J.; Pohl, R.; Ernsting, N. P.; Orság, P.; Fojta, M.; Hocek, M.: "Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA–protein interactions" Chem. Sci. 2012, 3, 2797–2806.
144.	Perlíková, P.; Jornet Martínez, N.; Slavětínská, L.; Hocek, M.: "Synthesis of 2'-deoxy-2'-fluororibo- and 2'-deoxy-2',2'-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines" Tetrahedron 2012, 68, 8300-8310.
143.	Nauš, P.; Perlíková, P.; Bourderioux, A.; Pohl, R.; Slavětínská, L.; Votruba, I.; Bahador, G.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides" Bioorg. Med. Chem. 2012, 20, 5202–5214.
142.	Raindlová, V.; Pohl, R.; Klepetářová, B.; Havran, L.; Šimková, E.; Horáková, P.; Pivoňková, H.; Fojta, M.; Hocek, M.: "Synthesis of Hydrazone-Modified Nucleotides and Their Polymerase Incorporation onto DNA for Redox Labeling" ChemPlusChem 2012, 77, 652–662.
141.	Ménová, P.; Hocek, M.: "Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction" Chem. Commun. 2012, 48, 6921–6923.
140.	Čerňová, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "A General Regioselective Synthesis of 2,4-Diarylpyrimidines from 2-Thiouracil through Two Orthogonal Cross-Coupling Reactions" Synlett 2012, 23, 1305–1308.
139.	Raindlová, V.; Pohl, R.; Hocek, M.: "Synthesis of Aldehyde-Linked Nucleotides and DNA and Their Bioconjugations with Lysine and Peptides through Reductive Amination" Chem. Eur. J. 2012, 18, 4080-4087.
138.	Chapuis, H.; Kubelka, T.; Joubert, N.; Pohl, R.; Hocek, M.: "Synthesis of 6-Substituted 2(1H)-Pyridon-3-yl C-2'-Deoxyribonucleosides" Eur. J. Org. Chem. 2012, 1759-1767.
137.	Kubelka, T.; Slavětínská, L.; Hocek, M.: "A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides" Synthesis 2012, 44, 953-965.
136.	Riedl, J.; Pohl, R.; Rulíšek, L.; Hocek, M.: "Synthesis and Photophysical Properties of Biaryl-Substituted Nucleos(t)ides. Polymerase Synthesis of DNA Probes Bearing Solvatochromic and pH-Sensitive Dual Fluorescent and 19F NMR Labels" J. Org. Chem. 2012, 77, 1026-1044.
135.	Kalachová, L.; Pohl, R.; Hocek, M.: "Synthesis of nucleoside mono- and triphosphates bearing oligopyridine ligands, their incorporation into DNA and complexation with transition metals" Org. Biomol. Chem. 2012, 10, 49-55.
2011
134.	Balintová, J.; Pohl, R.; Horáková, P.; Vidláková, P.; Havran, L.; Fojta, M.; Hocek, M.: "Anthraquinone as a Redox Label for DNA: Synthesis, Enzymatic Incorporation, and Electrochemistry of Anthraquinone-Modified Nucleosides, Nucleotides, and DNA" Chem. Eur. J. 2011, 17, 14063–14073.
133.	Hocek, M.; Fojta, M.: "Nucleobase modification as redox DNA labelling for electrochemical detection" Chem. Soc. Rev. 2011, 40, 5802–5814.
132.	Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: "Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727 –8730.
131.	Štambaský, J.; Kapras, V.; Štefko, M.; Kysilka, O.; Hocek, M.; Malkov, A. V.; Kočovský, P.: "A Modular Approach to Aryl-C-ribonucleosides via the Allylic Substitution and Ring-Closing Metathesis Sequence. A Stereocontrolled Synthesis of All Four α-/β- and D-/L- C-Nucleoside Stereoisomers" J. Org. Chem. 2011, 76, 7781–7803.
130.	Štefko, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups" J. Org. Chem. 2011, 76, 6619–6635.
129.	Standara, S.; Bouzková, K.; Straka, M.; Zacharová, Z.; Hocek, M.; Marek, J.; Marek, R.: "Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines" Phys. Chem. Chem. Phys. 2011, 13, 15854–15864.
128.	Lund, T. J.; Cavanaugh, N. A.; Joubert, N.; Urban, M.; Patro, J. N.; Hocek, M.; Kuchta, R. D.: "B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines" Biochemistry 2011, 50, 7243-7250.
127.	Nečas, D.; Hidasová, D.; Hocek, M.; Kotora, M.: "Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides" Org. Biomol. Chem. 2011, 9, 5934–5937.
126.	Fojta, M.; Havran, L.; Pivoňková, H.; Horáková, P.; Hocek, M.: "Redox Labels and Indicators Based on Transition Metals and Organic Electroactive Moieties for Electrochemical Nucleic Acids Sensing" Curr. Org. Chem. 2011, 15, 2936-2949.
125.	Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: " Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines " J. Med. Chem. 2011 , 54 , 5498–5507.
124.	Čerňová, M.; Čerňa, I.; Pohl, R.; Hocek, M.: " Regioselective Direct C-H Arylations of Protected Uracils. Synthesis of 5- and 6-Aryluracil Bases " J. Org. Chem. 2011 , 76 , 5309-5319.
123.	Nauš, P.; Perlíková, P.; Pohl, R.; Hocek, M.: " Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2'- C -methylribonucleosides, arabinonucleosides and 2'-deoxy-2'-fluoroarabinonucleosides " Collect. Czech. Chem. Commun. 2011 , 76 , 957-988.
122.	Stevens, K.; Claeys, D.D.; Catak, S.; Figaroli, S.; Hocek, M.; Tromp, J.M.; Schürch, S.; Speybroeck, V.; Madder, A.: " Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks—On the Benefit of Restoring the Cyclic Sugar Backbone " Chem. Eur. J. 2011 , 17 , 6940-6953.
121.	Macíčková-Cahová, H.; Pohl, R.; Horáková, P.; Havran, L.; Špaček, J.; Fojta, M.; Hocek, M.: " Alkylsulfanylphenyl Derivatives of Cytosine and 7-Deazaadenine Nucleosides, Nucleotides and Nucleoside Triphosphates: Synthesis, Polymerase Incorporation to DNA and Electrochemical Study " Chem. Eur. J. 2011 , 17 , 5833–5841.
120.	Kielkowski, P.; Pohl, R.; Hocek, M.: " Synthesis of Acetylene Linked Double-Nucleobase Nucleos(t)ide Building Blocks and Polymerase Construction of DNA Containing Cytosines in the Major Groove " J. Org. Chem. 2011 , 76 , 3457–3462.
119.	Horáková, P.; Macíčková-Cahová, H.; Pivoňková, H.; Špaček, J.; Havran, L.; Hocek, M.; Fojta, M.: " Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl tranferase. Application in electrochemical DNA hybridization and protein-DNA binding assays " Org. Biomol. Chem. 2011 , 9 , 1366 – 1371.
118.	Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: " Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases " ChemBioChem 2011 , 12 , 431 – 438.
117.	Perlíková, P.; Pohl, R.; Votruba, I.; Shih, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: " Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides " Bioorg. Med. Chem. 2011 , 19 , 229-242.
2010
116.	Opekar, S.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.; Kotora, M.: " [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with ?,?-Diynes " Heterocycles 2010 , 82 , 895-907.
115.	Štefko, M.; Hocek, M.: " Synthesis of Phenol and Pyridone C-Ribo- and 2'-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides " Synthesis 2010 , 4199–4206.
114.	Bárta, J.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: " Modular Synthesis of 5-Substituted Furan-2-yl C-2'-Deoxyribonucleosides and Biaryl Covalent Base-Pair Analogues " Eur. J. Org. Chem. 2010 , 5432–5443.
113.	Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: " CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases " ChemMedChem 2010 , 5 , 1386–1396.
112.	Kubelka, T.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: " Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2'-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides " Eur. J. Org. Chem. 2010 , 2666–2669.
111.	Marek, R.; Křístková, A.; Maliňáková, K.; Toušek, J.; Marek, J.; Hocek, M.; Malkina, O.L.; Malkin, V.G.: " Interpretation of Indirect Nuclear Spin-Spin Couplings in Isomers of Adenine: Novel Approach to Analyze Coupling Electron Deformation Density Using Localized Molecular Orbitals " J. Phys. Chem. A 2010 , 114 , 6689–6700.
110.	Standara, S.; Maliňáková, K.; Marek, R.; Marek, J.; Hocek, M.; Vaara, J.; Straka, M.: " Understanding the NMR chemical shifts for 6-halopurines: role of structure, solvent and relativistic effects " Phys. Chem. Chem. Phys. 2010 , 12 , 5126–5139.
109.	Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Intramolecular Direct C-H Arylation Approach to Fused Purines. Synthesis of Purino[8,9-f]phenanthridines and 5,6-Dihydropurino[8,9-a]isoquinolines " J. Org. Chem. 2010 , 75 , 2302–2308.
108.	Hasník, Z.; Pohl, R.; Hocek, M.: " Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides " Tetrahedron Lett. 2010 , 51 , 2464–2466.
107.	Raindlová, V; Pohl, R.; Šanda, M.; Hocek, M.: " Direct Polymerase Synthesis of Reactive Aldehyde-Functionalized DNA and Its Conjugation and Staining with Hydrazines " Angew. Chem. Int. Ed. 2010 , 49 , 1064–1066.
106.	Macíčková-Cahová, H.; Vrábel, M.; Hocek, M.: " Cross-Coupling Modification of Nucleoside Triphosphates, PEX, and PCR Construction of Base-Modified DNA " Curr. Protoc. Chem Biol. 2010 , 2 , 1-14.
105.	Ikonen, S.; Macíčková-Cahová, H.; Pohl, R.; Šanda, M.; Hocek, M.: " Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA " Org. Biomol. Chem. 2010 , 8 , 1194-1201.
104.	Urban, M.; Joubert, N.; Purse, B.W.; Hocek, M.; Kuchta, R. D.: " Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate " Biochemistry 2010 , 49 , 727–735.
103.	Štefko, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: " A General and Efficient Synthesis of Pyridin-2-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Amino, and Carbamoyl Groups in Position 6 " J. Org. Chem. 2010 , 75 , 442–449.
102.	Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkus, G.; Wang, T.; Ray, A.S.; Mackman, R.; Cihlar, T.; Hocek, M.: " 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents " J. Med. Chem. 2010 , 53 , 460–470.
101.	Bobula, T.; Hocek, M.; Kotora, M.: " Sonogashira reactions of ?- and ß-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides " Tetrahedron 2010 , 66 , 530–536.
2009
100.	Macíčková-Cahová, H.; Hocek, M.: " Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases " Nucleic Acids Res. 2009 , 37 , 7612–7622.
99.	Štambaský, J.; Hocek, M.; Kočovský, P.: " C-Nucleosides: Synthetic Strategies and Biological Applications " Chem. Rev. 2009 , 109 , 6729–6764.
98.	Urban, M.; Joubert, N.; Hocek, M.; Alexander, R. E.; Kuchta, R. D.: " Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase " Biochemistry 2009 , 48 , 10866-10881.
97.	Zendlová, L.; Řeha, D.; Hocek, M.; Hobza, P.: " Theoretical Study of the Stability of the DNA Duplexes Modified by a Series of Hydrophobic Base Analogues " Chem. Eur. J. 2009 , 15 , 7601-7610.
96.	Čerňová, M.; Pohl, R.; Hocek, M.: " Switching the Regioselectivity of Direct C–H Arylation of 1,3-Dimethyluracil " Eur. J. Org. Chem. 2009 , 3698-3701.
95.	Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Synthesis of (Purin-6-yl)acetates and Their Transformations to 6-(2-Hydroxyethyl)- and 6-(Carbamoylmethyl)purines " Collect. Czech. Chem. Commun. 2009 , 74 , 1035-1059.
94.	Riedl, J.; Horáková, P.; Šebest, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M.: " Tetrathiafulvalene-Labelled Nucleosides and Nucleoside Triphosphates: Synthesis, Electrochemistry and the Scope of Their Polymerase Incorporation into DNA " Eur. J. Org. Chem. 2009 , 3519-3525.
93.	Štefko, M.; Pohl, R.; Hocek, M.: " Synthesis of benzamide- C -ribonucleosides by Pd-catalyzed aminocarbonylations " Tetrahedron 2009 , 65 , 4471-4483.
92.	Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoroborates; The Scope and Limitations in the Synthesis of Modified Purines " Synthesis 2009 , 1309-1317.
91.	Klečka, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Direct C–H borylation and C–H arylation of pyrrolo[2,3- d ]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines " Org. Biomol. Chem. 2009 , 7 , 866-868.
90.	Vrábel, M.; Horáková, P.; Pivoňková, H.; Kalachova, L.; Černocká, H.; Cahová, H.; Pohl, R.; Šebest, P.; Havran, L.; Hocek, M.; Fojta, M.: " Base-Modified DNA Labeled by [Ru(bpy) 3 ] 2+ and [Os(bpy) 3 ] 2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications " Chem. Eur. J. 2009 , 15 , 1144-1154.
89.	Kalachova, L.; Pohl, R.; Hocek, M.: " Synthesis of 2'-Deoxyuridine and 2'-Deoxycytidine Nucleosides Bearing Bipyridine and Terpyridine Ligands at Position 5 " Synthesis 2009 , 105-112.
2008
88.	Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: " Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication " ChemBioChem 2008 , 9 , 2796-2799.
87.	Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C-H Arylation Reactions " J. Org. Chem. 2008 , 73 , 9048-9054.
86.	Cahová, H.; Pohl, R.; Bednárová, L.; Nováková, K.; Cvačka, J.; Hocek, M.: " Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA " Org. Biomol. Chem. 2008 , 6 , 3657-3660.
85.	Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines " Tetrahedron 2008 , 64 , 10355-10364.
84.	Srnec, M.; Chalupský, J.; Fojta, M.; Zendlová, L.; Havran, L.; Hocek, M.; Kývala, M.; Rulíšek, M.: " Effect of Spin-Orbit Coupling on Reduction Potentials of Octahedral Ruthenium(II/III) and Osmium(II/III) Complexes " J. Am. Chem. Soc. 2008 , 130 , 10947-10954.
83.	Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M.: " Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7 " Org. Biomol. Chem. 2008 , 6 , 2852-2860.
82.	Nauš, P.; Kuchař, M.; Hocek, M.: " Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides " Collect. Czech. Chem. Commun. 2008 , 73 , 665-678.
81.	Hocek, M.; Fojta, M.: " Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids " Org. Biomol. Chem. 2008 , 6 , 2233-2241.
80.	Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: " Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations " Org. Biomol. Chem. 2008 , 6 , 2377-2387.
79.	Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: " Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization " Eur. J. Org. Chem. 2008 , 3335-3343.
78.	Joubert, N.; Urban, M.; Pohl, R.; Hocek, M.: " Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C -2'-Deoxyribonucleosides " Synthesis 2008 , 1918-1932.
77.	Bambuch, V.; Pohl, R.; Hocek, M.: " Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides " Eur. J. Org. Chem. 2008 , 2783-2788.
76.	Bárta, J.; Pohl, R.; Klepetářová, B.; Ernsting, N. P.; Hocek, M.: " Modular Synthesis of 5-Substituted Thiophen-2-yl C -2'-Deoxyribonucleosides " J. Org. Chem. 2008 , 73 , 3798-3806.
75.	Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: " Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C -nucleosides, C -di- and C -trisaccharide analogues " Tetrahedron 2008 , 64 , 5200-5207.
74.	Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: " Synthesis, cytostatic and anti-HCV activity of 6-( N -substituted aminomethyl)-, 6-( O -substituted hydroxymethyl)- and 6-( S -substituted sulfanylmethyl)purine nucleosides " Bioorg. Med. Chem. 2008 , 16 , 2329-2366.
73.	Štefko, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: " A Modular Methodology for the Synthesis of 4- and 3-Substituted Benzene and Aniline C-Ribonucleosides " Eur. J. Org. Chem. 2008 , 1689-1704.
72.	Cahová, H.; Havran, L.; Brázdilová, P.; Pivoňková, H.; Pohl, R.; Fojta, M.; Hocek, M.: " Aminophenyl- and Nitrophenyl-Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection " Angew. Chem. Int. Ed. 2008 , 47 , 2059–2062.
71.	Hasník, Z.; Šilhár, P.; Hocek, M.: " Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide – Scope and Limitations of the Reaction " Synlett 2008 , 543–546.
70.	Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: " Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides " Bioorg. Med. Chem. 2008 , 16 , 1400–1424.
2007
69.	Brázdilová, P.; Vrábel, M.; Pohl, R.; Pivoňková, H.; Havran, L.; Hocek, M.; Fojta, M.: " Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry, and Bioanalytical Applications " Chem. Eur. J. 2007 , 13 , 9527–9533.
68.	Čerňa, I.; Pohl, R.; Hocek, M.: " The first direct C–H arylation of purine nucleosides " Chem. Commun. 2007 , 4729-4730.
67.	Joubert, N.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Modular and Practical Synthesis of 6-Substituted Pyridin-3-yl C-Nucleosides " J. Org. Chem. 2007 , 72 , 6797-6805.
66.	Vrábel, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: " Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions " Org. Biomol. Chem. 2007 , 5 , 2849–2857.
65.	Hasník, Z.; Šilhár, P.; Hocek, M.: " Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent " Tetrahedron Lett. 2007 , 48 , 5589–5592.
64.	Čapek, P.; Cahová, H.; Pohl, R.; Hocek, M.; Gloeckner, C.; Marx, A.: " An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross-Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR " Chem. Eur. J. 2007 , 13 , 6196–6203.
63.	Hocek, M.; Šilhár, P.: " Palladium-Catalyzed Cross-Coupling Reactions in C6 Modifications of Purine Nucleosides " Curr. Protocols Nucleic Acid Chem. (J. Wiley & Sons., Inc.) 2007 , 1.16.
62.	Vrábel, M.; Hocek, M.; Havran, L.; Fojta, M.; Votruba, I.; Klepetářová, B.; Pohl, R.; Rulíšek, L.; Zendlová, L.; Hobza, P.; Shih, I.; Mabery, E.; Mackman, R.: " Purines Bearing Phenanthroline or Bipyridine Ligands and Their Ru II Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity " Eur. J. Inorg. Chem. 2007 , 1752-1769.
61.	Beckman, J.; Kincaid, K.; Hocek, M.; Spratt, T.; Engels, J.; Cosstick, R.; Kuchta, R. D.: " Human DNA Polymerase ? Uses a Combination of Positive and Negative Selectivity To Polymerize Purine dNTPs with High Fidelity " Biochemistry 2007 , 46 , 448-460.
2006
60.	Čerňa, I.; Pohl, R.; Klepetářová, B.; Hocek, M.: " Direct C-H Arylation of Purines: Development of Methodology and Its Use in Regioselective Synthesis of 2,6,8-Trisubstituted Purines " Org. Lett. 2006 , 8 , 5389-5392.
59.	Hocek, M.; Šilhár, P.; Pohl, R.: " Cytostatic and activiral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3'-deoxyribonucletides " Collect. Czech. Chem. Commun. 2006 , 71 , 1484-1496.
58.	Turek, P.; Novák, P.; Pohl, R.; Hocek, M.; Kotora, M.: " Preparation of Highly Substituted 6-Arylpurine Ribonucleosides by Ni-Catalyzed Cyclotrimerization. Scope of the Reaction " J. Org. Chem. 2006 , 71 , 8978-8981.
57.	Kuchař, M.; Pohl, R.; Votruba, I.; Hocek, M.: " Synthesis of Purines Bearing Functionalized C-Substituents by the Conjugate Addition of Nucleophiles to 6-Vinylpurines and 6-Ethynylpurines " Eur. J. Org. Chem. 2006 , 5083-5098.
56.	Čapek, P.; Vrábel, M.; Hasník, Z.; Pohl, R.; Hocek, M.: " Aqueous-Phase Suzuki-Miyaura Cross-Coupling Reactions of Free Halopurine Bases " Synthesis 2006 , 3515-3526.
55.	Hocek, M.; Šilhár, P.; Shih, I.; Mabery, E.; Mackman, R.: " Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine L-ribonucleosides " Bioorg. Med. Chem. Lett. 2006 , 16 , 5290–5293.
54.	Urban, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: " New Modular and Efficient Approach to 6-Substituted Pyridin-2-yl C-Nucleosides " J. Org. Chem. 2006 , 71 , 7322-7328.
53.	Čapek, P.; Pohl, R.; Hocek, M.: " Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines. " Org. Biomol. Chem. 2006 , 4 , 2278-2284.
52.	Šilhár, P.; Pohl, R.; Votruba, I.; Klepetářová, B.; Hocek, M.: " Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl- 2-(Hydroxymethyl)purine Bases and Nucleosides " Collect. Czech. Chem. Commun. 2006 , 71 , 788-803.
51.	Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: " Synthesis and Cytostatic Activity of Novel 6-(Difluoromethyl)purine Bases and Nucleosides " Synthesis 2006 , 1848-1852.
50.	Novák, P.; Pohl, R.; Kotora, M.; Hocek, M.: " Synthesis of C-Aryldeoxyribosides by [2 + 2 + 2]-Cyclotrimerization Catalyzed by Rh, Ni, Co, and Ru Complexes " Org. Lett. 2006 , 8 , 2051-2054.
49.	Řeha, D.; Hocek, M.; Hobza, P.: " Exceptional Thermodynamic Stability of DNA Duplexes Modified by Nonpolar Base Analogues Is due to Increased Stacking Interactions and Favorable Solvation: Correlated Ab Initio Calculations and Molecular Dynamics Simulations " Chem. Eur. J. 2006 , 12 , 3587-3595.
2005
48.	Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: " Synthesis of 2-Substituted 6-(Hydroxymethyl)Purine Bases and Nucleosides " Collect. Czech. Chem. Commun. 2005 , 70 , 1669-1695.
47.	Čapek, P.; Hocek, M.: " Efficient One-Step Synthesis of Optically Pure (Adenin-8-yl)phenylalanine Nucleosides " Synlett 2005 , 3005-3007.
46.	Hocek, M.; Pohl, R.; Klepetářová, B.: " A New Modular and Practical Methodology for the Synthesis of 4- or 3-Substituted Phenyl C-Nucleosides " Eur. J. Org. Chem. 2005 , 4525-4528.
45.	Čapek, P.; Pohl, R.; Hocek, M.: " Synthesis of Enantiomerically Pure (Purin-6-yl)phenylalanines and Their Nucleosides, a Novel Type of Purine-Amino Acid Conjugates " J. Org. Chem. 2005 , 70 , 8001-8008.
44.	Hocek, M.; Nauš, P.; Pohl, R.; Votruba, I.; Furman, P. A.; Tharnish, P. M.; Otto, M. J.: " Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides " J. Med. Chem. 2005 , 48 , 5869-5873.
43.	Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: " The First Synthesis and Cytostatic Activity of Novel 6-(Fluoromethyl)purine Bases and Nucleosides " Org. Biomol. Chem. 2005 , 3 , 3001-3007.
42.	Hocek, M.; Pohl, R.; Císařová, I.: " Highly Methylated Purines and Purinium Salts as Analogues of Heteromines " Eur. J. Org. Chem. 2005 , 3026-3030.
41.	Turek, P.; Kotora, M.; Hocek, M.; Votruba, I.: " Novel Method for Preparation of Highly Substituted 6-Arylpurines by Reactions of 6-Alkynylpurines with Zirconacyclopentadienes " Collect. Czech. Chem. Commun. 2005 , 70 , 339-349.
2004
40.	Turek, P.; Kotora, M.; Tišlerová, I.; Hocek, M.; Votruba, I.; Císařová, I.: " Cocyclotrimerization of 6-Alkynylpurines with α,ω-Diynes as a Novel Approach to Biologically Active 6-Arylpurines " J. Org. Chem. 2004 , 69 , 9224-9233.
39.	Hocek, M.; Pohl, R.: " Regioselectivity in Cross-Coupling Reactions of 2,6,8-Trichloro-9-(tetrahydropyran-2-yl)purine: Synthesis of 2,6,8-Trisubstituted Purine Bases " Synthesis 2004 , 2869-2876.
38.	Čapek, P.; Pohl, R.; Hocek, M.: " A Facile and Efficient Synthesis of (Purin-6-yl)alanines " J. Org. Chem. 2004 , 69 , 7985-7988.
37.	Nauš, P.; Votruba, I.; Hocek, M.: " Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides " Collect. Czech. Chem. Commun. 2004 , 69 , 1955-1970.
36.	Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: " Facile and Efficient Synthesis of 6-(Hydroxymethyl)purines " Org. Lett. 2004 , 6 , 3225-3228.
35.	Sečkářová, P.; Marek, R.; Maliňáková, K.; Kolehmainen, E.; Hocková, D.; Hocek, M.; Sklenář, V.: " Direct Determination of Tautomerism in Purine Derivatives by Low-Temperature NMR Spectroscopy " Tetrahedron Lett. 2004 , 45 , 6259-6263.
34.	Hocek, M.: " Synthesis of Protected (Purin-6-yl)glycines via Pd-Catalyzed ?-Arylation of Ethyl N-(Diphenylmethylidene)glycinate with 6-Iodopurines " Heterocycles 2004 , 63 , 1673-1677.
33.	Hocek, M.; Hocková, D.; Dvořáková, D.: " Dichotomy in Regioselective Cross-Coupling Reactions of 6,8-Dichloropurines with Phenylboronic Acid and Methylmagnesium Chloride: Synthesis of 6,8-Disubstituted Purines " Synthesis 2004 , 889-894.
32.	Hocek, M.; Štěpnička, P.; Ludvík, J.; Císařová, I.; Votruba, I.; Řeha, D.; Hobza, P.: " Ferrocene-Modified Purines as Potential Electrochemical Markers: Synthesis, Crystal Structures, Electrochemistry and Cytostatic Activity of (Ferrocenylethynyl)- and (Ferrocenylethyl)purines " Chem. Eur. J. 2004 , 10 , 2058-2066.
2003
31.	Hocek, M.: " C-C and C-X Bond Formation by Cross-coupling Reactions Catalyzed by Transition Metal Complexes (in Czech) " Chem. Listy 2003 , 97 , 1145-1150.
30.	Hocek, M.; Dvořák, D.; Havelková, M.: " Covalent Analogues of Nucleobase-Pairs " Nucleosides, Nucleotides Nucleic Acids 2003 , 22 , 775-777.
29.	Hocek, M.; Dvořáková, H.: " An Efficient Synthesis of 2-Substituted 6-Methylpurine Bases and Nucleosides by Fe- or Pd-Catalyzed Cross-Coupling Reactions of 2,6-Dichloropurines " J. Org. Chem. 2003 , 68 , 5773-5776.
28.	Hocek, M.; Hocková, D.; Štambaský, J.: " Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides " Collect. Czech. Chem. Commun. 2003 , 68 , 837-848.
27.	Turek, P.; Kotora, M.; Hocek, M.; Císařová, I.: " [2+2+2]-Co-cyclotrimerization of 6-Alkynylpurines with Diynes: a Method for Preparation 6-Arylpurines " Tetrahedron Lett. 2003 , 44 , 785-788.
26.	Hocek, M.; Votruba, I.; Dvořáková, H.: " Synthesis of Carba-Analogues of Myoseverine by Regioselective Cross-coupling Reactions of 2,6-Dichloro-9-isopropylpurine " Tetrahedron 2003 , 59 , 607-611.
25.	Hocek, M.: " Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal- or Organometallics-Mediated C-C Bond Forming Reactions " Eur. J. Org. Chem . 2003 , 245-254.
2002
24.	Hocek, M.; Dvořáková, H.; Císařová, I.: " Covalent Analogues of DNA Base-Pairs and Triplets V. Synthesis of Purine-Purine and Purine-Pyrimidine Conjugates Connected By Diverse Types of Acyclic Carbon Linkages " Collect. Czech. Chem. Commun. 2002 , 67 , 1560-1578.
23.	Hocek, M.; Starý, I.; Stará, I. G.; Dvořáková, H.: " Covalent Analogues of DNA Base-Pairs and Triplets IV. Synthesis of trisubstituted benzenes bearing purine and/or pyrimidine rings by cyclotrimerization of 6-ethynylpurines and/or 5-ethynyl-1,3-dimethyluracil " Collect. Czech. Chem. Commun. 2002 , 67 , 1223-1235.
22.	Havelková, M.; Dvořák, D.; Hocek, M. " Covalent Analogues of DNA Base-Pairs and Triplets III. Synthesis of 1,4- and 1,3-bis(purin-6-yl)benzenes and 1-(1,3-dimethyluracil-5-yl)-3 or 4-(purin-9-yl)benzenes " Tetrahedron 2002 , 58 , 7431-7435.
21.	Hocek, M.; Holý, A.; Dvořáková, H.: " Cytostatic 6-Arylpurine Nucleosides IV. Synthesis of 2-Substituted 6-Phenylpurine Ribonucleosides " Collect. Czech. Chem. Commun. 2002 , 67 , 325-335.
20.	Hocek, M.; Votruba, I.: " Covalent Analogues of DNA Base-Pairs and Triplets II. Synthesis and Cytostatic Activity of is(purin-6-yl)acetylenes, -diacetylenes and Related Compounds " Bioorg. Med. Chem. Lett. 2002 , 12 , 1055-1057.
2001
19.	Havelková, M.; Dvořák, D.; Hocek, M.: " The Suzuki-Miyaura Cross-Coupling Reactions of 2-, 6- or 8-Halopurines with Boronic Acids Leading to 2-, 6- or 8-Aryl- or -Alkenylpurine Derivatives " Synthesis 2001 , 1704-1710.
18.	Hocek, M.; Holý, A.; Votruba, I.; Dvořáková, H.: " Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides " Collect. Czech. Chem. Commun. 2001 , 66 , 483-499.
17.	Hocek, M.; Starý, I.; Stará, I. G.; Dvořáková, H.: " Cyclotrimerization of 6-ethynylpurines. Synthesis of 1,2,4- and 1,3,5-tris(purin-6-yl)benzenes as novel Hoogsteen-triplet analogues. " Tetrahedron Lett . 2001 , 42 , 519-521.
2000
16.	Hocek, M.; Holý, A.; Votruba, I.; Dvořáková, H.: " Cytostatic 6-Arylpurine Nucleosides II. Synthesis of Sugar-Modified Derivatives: 9-(2-Deoxy-ß-D- erythro- pentofuranosyl)-, 9-(5-Deoxy-ß-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines " Collect. Czech. Chem. Commun. 2000 , 65 , 1683-1697.
15.	Hocek, M.: "Synthesis and Biological Activity of 2- and 6- C -Substituted Purine Bases, Nuceosides and Acyclic Nucleotide Analogues - Alfred Bader Award Lecture (in Czech)" Chem. Listy 2000 , 94 , 978-982.
14.	Česnek, M; Hocek, M; Holý, A.: " Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6- C -Substituted Purines via Cross-Coupling Reactions of 2-Amino-9-[2-(diisopropoxyphosphorylmethoxy)-ethyl]-6-halopurines with Diverse Organometallic Reagents " Collect. Czech. Chem. Commun. 2000 , 65 , 1357-1373.
13.	Hocek, M.; Holý, A.; Votruba, I.; Dvořáková, H.: " Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides: Application of the Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids " J. Med. Chem . 2000 , 43 , 1817-1825.
1999
12.	Hocková, D.; Hocek, M.; Dvořáková, H.; Votruba, I.:" Synthesis and Cytostatic Activity of Nucleosides and Acyclic Nucleoside Analogues Derived from 6-(Trifluoromethyl)purines " Tetrahedron 1999 , 55 , 11109-11118.
11.	Havelková, M.; Hocek, M.; Česnek, M.; Dvořák, D.: " The Suzuki-Miyaura Cross-Coupling Reactions of 6-Halopurines with Boronic Acids Leading to 6-Aryl and 6-Alkenylpurines " Synlett 1999 , 1145-1147.
10.	Hocek, M.; Holý, A.: ” Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues " Collect. Czech. Chem. Commun. 1999 , 64 , 229-241.
1997
9.	Hocek, M.; Masojídková, M.; Holý, A.: " Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents " Collect. Czech. Chem. Commun. 1997 , 62 , 136-146.
8.	Hocek, M.; Masojídková, M.; Holý, A.: " Synthesis of Acyclic Nucleotide Analogues Derived from N -Substituted 6-(1-Aminoethyl)purines via 6-Acetylpurine Derivatives " Tetrahedron 1997 , 53 , 2291-2302.
1996
7.	Hocek, M.; Masojídková, M.; Holý, A.; Andrei, G.; Snoeck, R.; Balzarini, J.; De Clercq, E.: " Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines " Collect. Czech. Chem. Commun. 1996 , 61 , 1525-1537.
6.	Hocek, M.; Holý, A.: "Acyclic Nucleotide Analogues Derived from 6-(1-Aminoalkyl)purines" Collect. Czech. Chem. Commun. 1996 , 61 (Special Issue) , S55-S58.
1995
5.	Hocek, M.; Holý, A: " A Facile Synthesis of 6-Cyanopurines " Collect. Czech. Chem. Commun. 1995 , 60 , 1386-1389.
4.	Hocek, M.; Masojídková, M.; Holý, A: " Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl)adenine and 2-(Aminomethyl)hypoxanthine " Collect. Czech. Chem. Commun. 1995 , 60 , 875-882.
1994
3.	Hocek, M. ;Masojídková, M.; Holý, A: " A Facile Synthesis of 2-(Aminomethyl)Purines " Synthesis 1994 , 1401-1402.
2.	Böhm, S.; Hocek, M.; Němeček, J.; Havlíček, V.; Kuthan, J.: " Preparation snd Spectroscopic Properties of Spirocyclic 1-Methyl-2,4,4,6-tetraaryl-1,4-dihydropyridines ." Collect. Czech. Chem. Commun. 1994 , 59 , 1105-1114.
1.	Böhm, S.; Hocek, M.; Nešpůrek, S.; Kuthan, J.: " Photocoloration of 2,4,4,6-Tetraaryl-1,4-dihydroppyridines; a Semiempirical Quantum Chemical Study. " Collect. Czech. Chem. Commun. 1994 , 59 , 262-272.

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