Senior Research Scientist in Proteomics (Research-service team Mass spectrometry)

We are looking for a highly competent and self-motivated research scientist in the area of proteomics and mass spectrometry to run proteomics projects in our core facility lab as a collaborative support for the diverse life-science research projects at the Institute of Organic Chemistry and Biochemistry AS CR, v.v.i. (IOCB) in Prague, Czech Republic. The expected starting date for the appointment is April 1, 2013.

RESPONSIBILITIES

• Development and application of MS-based proteomics methods for the discovery and quantification of proteins and peptides
• Collaborative and service support for the research projects at IOCB (see here for details)
• Supervision, operation and maintenance of mass spectrometers (mainly AB Sciex TripleTOF, partially Thermo LTQ Orbitrap XL and others)
• Supervision and training of 1-2 members of staff (technicians)

REQUIREMENTS
Education/Skills

• Ph.D. in science
• Substantial knowledge and working experience with advanced mass spectrometry technologies (Q-TOF, Orbitrap, TOF/TOF) and chromatography
• Know-how in qualitative and quantitative proteomics approaches (e.g., PTM identifications or SILAC)
• Experiences in data analysis

• Ability to effectively interact with research and technical staff in a team-oriented manner, ability to suggest and discuss experimental strategies with life-science research groups
• Highly motivated, result-focused, autonomous and organized person

OFFER

• A dynamic and international state-of-the-art working environment in one of the birthplaces of modern antiretrovirals, set in a vibrant and modern metropolitan capital
• Competitive salary commensurate to skills and experience
• Fixed-term contract for 3 years with expected renewal

APPLICATIONS For further information please contact the Head of Mass Spectrometry Research-Service Team Dr. Josef Cvačka directly by e-mail at cvacka@uochb.cas.cz. To apply, please send your CV, list of publications, motivation letter and contact details for 3 scientific references to the same address

Postdoctoral position in computational chemistry (Prof. Pavel Hobza)

Applications are invited for a postdoctoral position in the group of Prof. Pavel Hobza at the Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.

The applicant will work on development of algorithms for efficient optimization of large molecular systems in mixed cartesian/internal coordinates. This topic is an important part of our large project, the application of quantum-mechanical methods in computer-aided drug design. We are looking for candidates with solid programming skills and working knowledge of algebra. Previous experience with molecular geometry optimization algorithms is welcome but not necessary if substituted with other skills and a will to learn.

The position is open for one year with the possibility of further extensions. For details, please contact Helena Černá (helena.cerna@uochb.cas.cz).

Downloadable Instructions and Application forms:

• Instructions for EU countries (pdf file, 10 kB)
• Instructions for non-EU countries (pdf file, 18 kB)
• Instructions for non-EU countries (stay of less than 90 days): (pdf file, 85 kB)
• Medical certificate (pdf file, 59 kB)
• Affidavit (in English) (pdf file, 14 kB)
• Affidavit (in Czech) (pdf file, 82 kB)