Staff

Name Ledvina Miroslav
Position Head of the Team
Miroslav Ledvina, Ph.D.

Miroslav Ledvina, Ph.D.

Head of the Team

Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Phone: (+420) 220 183 370
Fax: (+420) 224 310 090

Education
1979-1983 Ph.D. in organic chemistry, under supervision of Dr. J.Farkaš at the Institute of Organic Chemistry and Biochemisty, Czechoslovak Academy of Sciences, Prague.
1970-1976 M.Sc. in organic chemistry, under supervision of Dr. J.Farkaš at the Institute of Organic Chemistry and Biochemisty, Czechoslovak Academy of Sciences, Prague.
Experience
1992-1993 Postdoctoral fellow with Dr. M.Bobek, Roswell Park Cancer Institute, Buffalo, New York, USA.
1983 (3 months) Postdoctoral fellow with Prof. Regina Zuk, Latvian Institute of Organic Synthesis, Riga, Latvia.
Appointments
since 2007 Head of the Technology Transfer Team - Laboratory of Glycoconjugates, Institute of Organic Chemistry and Biochemisty AS CR, v.v.i., Prague.
2005-2006 Head of the Group of Glycoconjugates, Department of Biological Chemistry, Institute of Organic Chemistry and Biochemisty AS CR, v.v.i., Prague.
1993-2005 Head of the Laboratory of Saccharides, Department of Nucleic Acid Chemistry and Biochemistry, Institute of Organic Chemistry and Biochemisty AS CR, v.v.i., Prague.
1976-1992 Group of Chemistry of Nucleic Acid Components, Department of Biological Chemistry, Institute of Organic Chemistry and Biochemisty AS CR, v.v.i., Prague.
Research interest
Chemistry of saccharides, oligosaccharides, and glycoconjugates, and study of interactions of these structures with the recognition, defense, regulatory and transport systems in living organisms on molecular level; nano-chemistry focused on nanostructured delivery systems for target immunotherapy and chemotherapy; WP leader of recent European collaborative 7FP DINAMO project, focused on development of diamond intracellular nanoprobes; Co-founder and Chief executive officer (CEO) of the first Czech spin-off company (Mendel Therapeutic Ltd.) established with the aim to commercialize effectively scientific results (achieved in the field of nonpyrogenic normuramyl glycopeptides with immuno-stimulatory activities). The company wined the first prize in 2009 for the most innovative project within the South Moravian Innovation Centre.
Educational Activities and Popularization:
  • Member of the committee for M.Sc. and Ph.D. program at the Department of Organic Chemistry of the Faculty of Natural Sciences, Charles University, Prague; supervisor of Ph.D. and Diploma theses.
  • Member of the committee for M.Sc. and Ph.D. program of the Department of Chemistry of Natural Compounds of the Institute of Chemical Technology, Prague; supervisor of Ph.D. and Diploma theses.
Selected papers

 

Kovalová A., Ledvina M., Šaman D., Zyka D., Kubíčková M., Žídek L., Sklenář V., Pompach P., Kvan D., Bílý J., Vaněk O., Kubínková Z., Vančurová M., Antolíková M., Lejsková Z., Mrázek H., Rozbeský D., Hofbauerová K., Křen V., Bezouška K.:
Synthetic N-acetylglucosamine based fully branched tetrasaccharide, a mimetic of the endogenous ligand for CD69, activates CD69+ NK cells and killer lymphocytes upon dimerization via a hydrophilic flexible linker.
J. Med. Chem. 53: 4050–4065 (2010).

Turský M., Veselý J., Tišlerová I., Trnka T., Ledvina M.:
Synthesis of a new type of D-mannosamine glycosyl donor and acceptor and their use for the preparation of oligosaccharides consisting of D-mannosamine units linked by ?(1-›4)-glycosidic bondsa>
Sythesis : 2610-2616 (2008).

Wang X.-F., Birringer M., Dong L.-F.,Vepřek P., Low P., Swettenham E., Stantic M., Yuan L.-H., Zobalova R., Wu K., Ralph S.J., Ledvina M., Neuzil J.:
A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression.
Cancer Research 67 (7): 3337-3344, 2007.

Veselý J., Rohlenová A., Džoganová M., Ledvina M., Trnka T., Tišlerová I., Šaman D.:
Preparation of Ethyl 2-azido-2-deoxy-1-thio-?-D-mannopyranosides, and their rearrangement to 2-S-Ethyl-2-thio-?-D-mannopyranosylamines.
Sythesis : 699-705 (2006).

Turánek J., Kašná A., Koudela B., Ledvina M., Miller A.D.:
Stimulation of innate immunity in newborn kids against Cryptosporidium parvum infection-challenge by intranasal/per-oral administration of liposomal formulation of N-L 18-norAbu-GMDP adjuvant.
Parasitology 131: 601-608 (2005). Patents:

Ledvina M., Zyka D., Džoganová M.:
Deriváty kyselyny glukosaminylmuramové.
Czech Pat. CZ 301451 (2010).

Ledvina M., Turánek J., Miller A.D., Hipler K.:
Compound (Adjuvants).
PCT appl. WO 2009/11582 A2 (2009).

Ledvina M., Ježek J. , Hříbalová V., Turánek J.:
Lipofilní analogy N-acetyl-normuramyl-L-ß-aminobutanoyl-D-isoglutaminu s imunostimulační aktivitou.
Czech Pat. CZ 296 720 (2006).

Ledvina M., Pavelová R. , Ježek J., Rohlenová A., Hříbalová V., Mašek K.:
Karbaanalogy muramylovych glykopeptidů a způsob jejich přípravy.
Czech Pat. CZ 296 372 (2006).