Pospíšil, Stanislav; Sedmera, Petr; Halada, Petr; Havlíček, Libor; Spížek, Jaroslav
TETRAHEDRON LETTERS
45:
2943-2945,
2004
Klíčová slova:
lincomycin oxidation; hydrogen peroxide; alkaline
Abstrakt:
Oxidation of lincomycin with H2O2 in alkaline media leads to N-oxides, besides the conversion of thiomethyl group into sulfoxides and sulfones. NH4OH favors formation of the S-isomer; both R- and S-iosmers of the N-oxide are formed in the presence of NaOH. Addition of acetonitrile markedly accelerates the reaction.
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