Selected Publications

Adrain C., Strisovsky K., Zettl M., Hu L.D.A., Lemberg M.K. & Freeman M.:
Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
EMBO Reports 12: 421-427 (2011).

Pierrat* O.A., Strisovsky* K., Christova Y., Large J., Ansell K., Bouloc N., Smiljanic E. & Freeman M.:
Monocyclic beta-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
ACS Chemical Biology 6: 325-335 (2011).

Zettl M., Adrain C., Strisovsky K., Lastun V. & Freeman M.:
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.
Cell 145: 79-91 (2011).

Vinothkumar K.R., Strisovsky K., Andreeva A., Christova Y., Verhelst S. & Freeman M.:
The structural basis for catalysis and substrate specificity of a rhomboid protease.
EMBO Journal 29: 3797-3809 (2010).

Strisovsky K., Sharpe H.J. & Freeman M.:
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.
Molecular Cell 36: 1048-1059 (2009).

Stevenson L.G., Strisovsky K., Clemmer K.M., Bhatt S., Freeman M. & Rather P.N.:
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.
Proceedings of the National Academy of Sciences of the United States of America 104: 1003-1008 (2007).

^{* equal contribution}

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