Landa P., Skalova L., Bousova I., Kutil Z., Langhansova L., Lou J.-D., Vanek T.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
27[1]:
103-106,
2014
Klíčová slova:
anti-proliferative activity, anti-inflammatory activity, breast cancer, cyclooxygenase, Vaccinium bracteatum, xCELLigence system
Abstrakt:
The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
Autoři z ÚEB: Přemysl Landa,
Lenka Langhansová,
Tomáš Vaněk,
bývalý zaměstnanec
Čeština
English