Projects

The current project involves synthesis of estrone derivatives with the modified steroid D-rings. The modification involves mainly attachment of various side-chains with the appropriate functionality enabling further elaboration and modification. The first goal is to design and synthesize substances that would acts as antagonist of selected hydroxysteroid dehydrogenases (HSD). The second one is to develop new types of ligands for the selective binding to estrogen alpha or beta receptors (ERα and ERβ).