Structural chromosome aberrations in dividing cells lead to unequal distribution of DNA into daughter cells. This is reflected by the increase in variation of nuclear DNA content (increase of coefficient of variation of G1 and G2 peaks). In addition, higher doses may result in changes of cell cycle kinetics.
Figure 25. Histograms of nuclear DNA content in a Chinese hamster cell line exposed to increasing doses of X-rays, with CVs of the G1 peaks shown. The analysis was performed 24 h after irradiation (Otto and Oldiges, 1980)
