HomePh.D. Study at IOCBArchive - 2013Organic Chemistry

Organic Chemistry

Tutor Ing. Ivan Rosenberg, CSc.
Team

Ivan Rosenberg

Topic Phospholane ring-based nucleoside and nucleotide analogs
Faculty FCHT
Abstract

Project is directed towards so far not described nucleoside and nucleotide analogs in deoxy and ribo series, containing phospholane ring instead of the clasic pentofuranose ring. Phosphorus atom fosforu is located in the position of original C4' atom. The prepared modified nucleosides and nucleotides will be subjected to conformational analysis which should reveal the conformational changes of nucleobase and sugar pucker of the five-membered heterocyclus. The inhibition properties of new compounds will be studied with selected salvage pathway enzymes (nucleoside phosphorylases, nucleotidases, etc.), and also thorough antiviral, anticancer, and antimicrobial screening will be run.