Dvořáková M., Nencka R., Dejmek M., Zbornikova E., Březinová A., Přibylová M., Pohl R., Migaud M.E., Vaněk T.
ORGANIC & BIOMOLECULAR CHEMISTRY
11:
5702–5713,
2013
Klíčová slova:
Alkylcarbonate; Mechanical grinding; Ribose derivatives; Sirtuin
Abstrakt:
The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
Autoři z ÚEB: Marcela Dvořáková,
Marie Přibylová,
Tomáš Vaněk
Čeština
English